Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Mutations in a translation initiation factor identify the target of a memory-enhancing compound

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Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

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Pancreatic Adenocarcinoma

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Chemotherapy-induced dynamic gene expression changes in vivo are prognostic in ovarian cancer

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Endoplasmic Reticulum Stress in Malignancy

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Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras G12D -induced senescence

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Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation

(2014) H.-Q. Ju et al.   MOLECULAR CANCER THERAPEUTICS

DUSP1 Is a Novel Target for Enhancing Pancreatic Cancer Cell Sensitivity to Gemcitabine

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Pro-survival and pro-growth effects of stress-induced nitric oxide in a prostate cancer photodynamic therapy model

(2013) Reshma Bhowmick et al.   CANCER LETTERS

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

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EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

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Genetic inactivation ofNupr1acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

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An Undesired Effect of Chemotherapy

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Pancreatic cancer–associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological brake-release of mRNA translation enhances cognitive memory

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MUC1 induces drug resistance in pancreatic cancer cells via upregulation of multidrug resistance genes

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Overcoming nucleoside analog chemoresistance of pancreatic cancer: A therapeutic challenge

(2012) Sau Wai Hung et al.   CANCER LETTERS

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

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Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

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AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia

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Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B

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Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway

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Hallmarks of Cancer: The Next Generation

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BCL2A1: the underdog in the BCL2 family

(2011) M Vogler   CELL DEATH AND DIFFERENTIATION

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Phosphorylation of eIF2 Facilitates Ribosomal Bypass of an Inhibitory Upstream ORF to EnhanceCHOPTranslation

(2011) Lakshmi Reddy Palam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gemcitabine Plusnab-Paclitaxel Is an Active Regimen in Patients With Advanced Pancreatic Cancer: A Phase I/II Trial

(2011) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Aberrant signaling pathways in pancreatic cancer: A two compartment view

(2011) Angela L. McCleary-Wheeler et al.   MOLECULAR CARCINOGENESIS

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

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Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

(2011) M Donadelli et al.   Cell Death & Disease

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

Pancreatic cancer: understanding and overcoming chemoresistance

(2010) Zhiwei Wang et al.   Nature Reviews Gastroenterology & Hepatology

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Pancreatic cancer cells resistance to gemcitabine: the role of MUC4 mucin

(2009) S Bafna et al.   BRITISH JOURNAL OF CANCER

Eukaryotic Stress Granules: The Ins and Outs of Translation

(2009) J. Ross Buchan et al.   MOLECULAR CELL

HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma

(2008) S.-S. Liau et al.   CLINICAL CANCER RESEARCH

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

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