Truncated Tau Induces Mitochondrial Transport Failure Through the Impairment of TRAK2 Protein and Bioenergetics Decline in Neuronal Cells

AMPK preferentially depresses retrograde transport of axonal mitochondria during localised nutrient deprivation

(2020) Orla Watters et al.   JOURNAL OF NEUROSCIENCE

NADPH oxidase contributes to oxidative damage and mitochondrial impairment induced by acute ethanol treatment in rat hippocampal neurons

(2020) María José Pérez et al.   NEUROPHARMACOLOGY

It’s all about tau

(2019) Cheril Tapia-Rojas et al.   PROGRESS IN NEUROBIOLOGY

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution

(2018) Guillermo López‐Doménech et al.   EMBO JOURNAL

Tau Proteolysis in the Pathogenesis of Tauopathies: Neurotoxic Fragments and Novel Biomarkers

(2018) James P. Quinn et al.   JOURNAL OF ALZHEIMERS DISEASE

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca 2+ Stress

(2018) Neeharika Nemani et al.   Cell Reports

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

(2018) María J. Pérez et al.   Frontiers in Neuroscience

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Molecular Pathogenesis of the Tauopathies

(2018) Jürgen Götz et al.   Annual Review of Pathology-Mechanisms of Disease

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs

(2018) Hideki Shigematsu et al.   JOURNAL OF CELL BIOLOGY

Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer’s Disease

(2017) Kelly Hares et al.   JOURNAL OF ALZHEIMERS DISEASE

Developmental changes in trak-mediated mitochondrial transport in neurons

(2017) Omar Loss et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams

(2017) Abdullah R. Chaudhary et al.   TRAFFIC

The Interplay of Axonal Energy Homeostasis and Mitochondrial Trafficking and Anchoring

(2017) Zu-Hang Sheng   TRENDS IN CELL BIOLOGY

Co-expression of truncated and full-length tau induces severe neurotoxicity

(2016) S Ozcelik et al.   MOLECULAR PSYCHIATRY

Loss of Dendritic Complexity Precedes Neurodegeneration in a Mouse Model with Disrupted Mitochondrial Distribution in Mature Dendrites

(2016) Guillermo López-Doménech et al.   Cell Reports

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function

(2014) Csilla Ari et al.   NEUROBIOLOGY OF AGING

Phosphorylated tau potentiates Aβ-induced mitochondrial damage in mature neurons

(2014) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

(2013) Rodrigo A Quintanilla et al.   Molecular Neurodegeneration

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites

(2013) Myrrhe van Spronsen et al.   NEURON

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Trafficking Kinesin Protein (TRAK)-mediated Transport of Mitochondria in Axons of Hippocampal Neurons

(2011) Kieran Brickley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

(2011) Rodrigo A. Quintanilla et al.   NEUROBIOLOGY OF AGING

Defects in Mitochondrial Axonal Transport and Membrane Potential without Increased Reactive Oxygen Species Production in a Drosophila Model of Friedreich Ataxia

(2010) Y. Shidara et al.   JOURNAL OF NEUROSCIENCE

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Tau Reduction Prevents Aβ-Induced Defects in Axonal Transport: Fig. 1

(2010) Keith A. Vossel et al.   SCIENCE

The Miro GTPases: At the heart of the mitochondrial transport machinery

(2009) Katarina Reis et al.   FEBS LETTERS

Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons

(2009) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons

(2009) Y.-M. Chen et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Control of mitochondrial transport and localization in neurons

(2009) Andrew F. MacAskill et al.   TRENDS IN CELL BIOLOGY

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation

(2008) Jian-Sheng Kang et al.   CELL

Axonal Transport Rates In Vivo Are Unaffected by Tau Deletion or Overexpression in Mice

(2008) A. Yuan et al.   JOURNAL OF NEUROSCIENCE

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

(2008) R. Dixit et al.   SCIENCE