Identification of MYC as an antinecroptotic protein that stifles RIPK1–RIPK3 complex formation

RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events

(2020) Tom Delanghe et al.   TRENDS IN CELL BIOLOGY

The role of necroptosis in cancer: A double-edged sword?

(2019) Xia Qin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Coming Decade of Cell Death Research: Five Riddles

(2019) Douglas R. Green   CELL

The role of necroptosis in cancer biology and therapy

(2019) Yitao Gong et al.   Molecular Cancer

Targeting RIPK1 for the treatment of human diseases

(2019) Alexei Degterev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Diversification of Cell Death and Immunity: Memento Mori

(2019) Arnaud J. Legrand et al.   MOLECULAR CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression

(2018) Kezhou Zhu et al.   Cell Death & Disease

The roles of ubiquitination in extrinsic cell death pathways and its implications for therapeutics

(2018) Jinho Seo et al.   BIOCHEMICAL PHARMACOLOGY

PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP

(2017) Huibing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

(2016) Najoua Lalaoui et al.   CANCER CELL

RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells

(2016) Ulrike Höckendorf et al.   CANCER CELL

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

(2016) M Cristina de Almagro et al.   CELL DEATH AND DIFFERENTIATION

Cancer and necroptosis: friend or foe?

(2016) Stephan Philipp et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis

(2016) Giovanni Quarato et al.   MOLECULAR CELL

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

(2016) Sheela A. Abraham et al.   NATURE

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

Therapeutic targeting of necroptosis by Smac mimetic bypasses apoptosis resistance in acute myeloid leukemia cells

(2016) C Safferthal et al.   ONCOGENE

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

(2016) M Jeong et al.   ONCOGENE

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

(2016) Gabriela Brumatti et al.   Science Translational Medicine

Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL

(2016) Scott McComb et al.   Science Translational Medicine

Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it

(2015) S Yoon et al.   CELL DEATH AND DIFFERENTIATION

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics

(2015) Gi-Bang Koo et al.   CELL RESEARCH

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination

(2015) M C de Almagro et al.   Cell Death & Disease

Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death

(2015) K Moriwaki et al.   Cell Death & Disease

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

(2015) Bram Laukens et al.   NEOPLASIA

Stress-induced cleavage of Myc promotes cancer cell survival

(2014) M. Conacci-Sorrell et al.   GENES & DEVELOPMENT

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necroptosis, in vivo detection in experimental disease models

(2014) Sandrine Jouan-Lanhouet et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Therapeutic exploitation of necroptosis for cancer therapy

(2014) Simone Fulda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RIP3 is downregulated in human myeloid leukemia cells and modulates apoptosis and caspase-mediated p65/RelA cleavage

(2014) A-L Nugues et al.   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

(2013) L Steinhart et al.   Cell Death & Disease

MAX and MYC: A Heritable Breakup

(2012) A. Cascon et al.   CANCER RESEARCH

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

MYC oncogene in myeloid neoplasias

(2012) M. Dolores Delgado et al.   Clinical & Translational Oncology

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell Differentiation

(2010) Maralice Conacci-Sorrell et al.   CELL

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL