MYC oncogene in myeloid neoplasias

MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency

(2012) R. Moser et al.   MOLECULAR CANCER RESEARCH

MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27KIP1

(2012) M T Gómez-Casares et al.   ONCOGENE

Inhibition of the Intrinsic but Not the Extrinsic Apoptosis Pathway Accelerates and Drives Myc-Driven Tumorigenesis Towards Acute Myeloid Leukemia

(2012) Kari Högstrand et al.   PLoS One

Functional genomics identifies therapeutic targets for MYC-driven cancer

(2012) M. Toyoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression

(2011) C. M. Lucas et al.   BLOOD

Amplification of the G allele at SNP rs6983267 in 8q24 amplicons in myeloid malignancies as cause of the lack of MYC overexpression?

(2011) Lucia Micale et al.   BLOOD CELLS MOLECULES AND DISEASES

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

c-MYC Oncoprotein Dictates Transcriptional Profiles of ATP-Binding Cassette Transporter Genes in Chronic Myelogenous Leukemia CD34+ Hematopoietic Progenitor Cells

(2011) A. Porro et al.   MOLECULAR CANCER RESEARCH

MYC in Chronic Myeloid Leukemia: Induction of Aberrant DNA Synthesis and Association with Poor Response to Imatinib

(2011) M. Albajar et al.   MOLECULAR CANCER RESEARCH

E-box-independent regulation of transcription and differentiation by MYC

(2011) Iris Uribesalgo et al.   NATURE CELL BIOLOGY

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

(2011) Matilde Murga et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia

(2011) Renu Bajaj et al.   Molecular Cytogenetics

Concomitant and successive amplifications of MYC in APL-like leukemia

(2010) Hélène Bruyère et al.   CANCER GENETICS AND CYTOGENETICS

Inhibition of cell differentiation: A critical mechanism for MYC-mediated carcinogenesis?

(2010) Javier Leon et al.   CELL CYCLE

Increased MYC gene copy number correlates with increased mRNA levels in diffuse large B-cell lymphoma

(2010) C. J. Stasik et al.   HAEMATOLOGICA

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia

(2010) Zhifu Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome

(2010) Alzbeta Vasikova et al.   LEUKEMIA RESEARCH

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

(2010) D. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive genomic screens identify a role for PLZF-RAR  as a positive regulator of cell proliferation via direct regulation of c-MYC

(2009) K. L. Rice et al.   BLOOD

c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors

(2009) Y. Guo et al.   BLOOD

Gene amplification in myeloid leukemias elucidated by fluorescence in situ hybridization

(2009) Kathleen C. Rayeroux et al.   CANCER GENETICS AND CYTOGENETICS

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

(2009) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

(2009) L J Beverly et al.   ONCOGENE

Multilevel targeting of hematopoietic stem cell self-renewal, differentiation and apoptosis for leukemia therapy

(2009) Asterios S. Tsiftsoglou et al.   PHARMACOLOGY & THERAPEUTICS

Molecular biology of bcr-abl1-positive chronic myeloid leukemia

(2008) A. Quintas-Cardama et al.   BLOOD

Distinct Thresholds Govern Myc's Biological Output In Vivo

(2008) Daniel J. Murphy et al.   CANCER CELL

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Transcriptional regulatory networks in haematopoiesis

(2008) Diego Miranda-Saavedra et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Upregulation of c-myc gene accompanied by PU.1 deficiency in radiation-induced acute myeloid leukemia in mice

(2008) Tokuhisa Hirouchi et al.   EXPERIMENTAL HEMATOLOGY

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

Myc Inhibits p27-Induced Erythroid Differentiation of Leukemia Cells by Repressing Erythroid Master Genes without Reversing p27-Mediated Cell Cycle Arrest

(2008) J. C. Acosta et al.   MOLECULAR AND CELLULAR BIOLOGY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Transcription-independent functions of MYC: regulation of translation and DNA replication

(2008) Michael D. Cole et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of genes with abnormal expression changes in acute myeloid leukemia

(2007) Derek L. Stirewalt et al.   GENES CHROMOSOMES & CANCER