标题
On the Complexity of Mechanisms and Consequences of Chromothripsis: An Update
作者
关键词
-
出版物
Frontiers in Genetics
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2019-04-30
DOI
10.3389/fgene.2019.00393
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Very short DNA segments can be detected and handled by the repair machinery during germline chromothriptic chromosome reassembly
- (2018) Zuzana Slamova et al. HUMAN MUTATION
- Chromothripsis and ring chromosome 22: a paradigm of genomic complexity in the Phelan-McDermid syndrome (22q13 deletion syndrome)
- (2018) Nehir Kurtas et al. JOURNAL OF MEDICAL GENETICS
- History and evolution of cytogenetic techniques: Current and future applications in basic and clinical research
- (2018) Adayabalam S. Balajee et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Position effect, cryptic complexity, and direct gene disruption as disease mechanisms in de novo apparently balanced translocation cases
- (2018) Constantia Aristidou et al. PLoS One
- Genomic distribution of 5‐formylcytosine and 5‐carboxylcytosine in human preimplantation embryos
- (2018) Anna A. Pendina et al. MOLECULAR REPRODUCTION AND DEVELOPMENT
- Prevention of radiation-induced bystander effects by agents that inactivate cell-free chromatin released from irradiated dying cells
- (2018) Saurabh Kirolikar et al. Cell Death & Disease
- Insertional translocation involving an additional nonchromothriptic chromosome in constitutional chromothripsis: Rule or exception?
- (2018) Nehir Edibe Kurtas et al. Molecular Genetics & Genomic Medicine
- Mutual regulation of microRNAs and DNA methylation in human cancers
- (2017) Sumei Wang et al. Epigenetics
- Case of chromothripsis in a large solitary non-recurrent uterine leiomyoma
- (2017) Anna A. Pendina et al. European Journal of Obstetrics & Gynecology and Reproductive Biology
- Exosomal miR-7 Mediates Bystander Autophagy in Lung after Focal Brain Irradiation in Mice
- (2017) Shang Cai et al. International Journal of Biological Sciences
- Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1000 cases
- (2017) Larysa Y. Pylyp et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Genomic profiling of Acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis
- (2017) M Ratnaparkhe et al. LEUKEMIA
- The interplay of epigenetic marks during stem cell differentiation and development
- (2017) Yaser Atlasi et al. NATURE REVIEWS GENETICS
- Telomeres in cancer: tumour suppression and genome instability
- (2017) John Maciejowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis
- (2017) Peter Ly et al. TRENDS IN CELL BIOLOGY
- Genome-wide 5-hydroxymethylcytosine patterns in human spermatogenesis are associated with semen quality
- (2017) Olga A. Efimova et al. Oncotarget
- Chromatin reorganisation in Epstein-Barr virus-infected cells and its role in cancer development
- (2017) Michelle J West Current Opinion in Virology
- Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells
- (2017) Sjors Middelkamp et al. Genome Medicine
- Impaired nuclear functions in micronuclei results in genome instability and chromothripsis
- (2016) Mariona Terradas et al. ARCHIVES OF TOXICOLOGY
- A rare example of germ-line chromothripsis resulting in large genomic imbalance
- (2016) Sarah E. Anderson et al. CLINICAL DYSMORPHOLOGY
- The epigenetics of tumour initiation: cancer stem cells and their chromatin
- (2016) Alexandra Avgustinova et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Heterogeneity of a Constitutional Complex Chromosomal Rearrangement in 2q
- (2016) Javier Del Rey et al. CYTOGENETIC AND GENOME RESEARCH
- How can mate-pair sequencing be utilized for cancer patients?
- (2016) Ge Gao et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- A Distinct Class of Chromoanagenesis Events Characterized by Focal Copy Number Gains
- (2016) Heleen Masset et al. HUMAN MUTATION
- Germline Chromothripsis Driven by L1-Mediated Retrotransposition and Alu/Alu Homologous Recombination
- (2016) Lusine Nazaryan-Petersen et al. HUMAN MUTATION
- Telomere dysfunction and chromothripsis
- (2016) Aurélie Ernst et al. INTERNATIONAL JOURNAL OF CANCER
- First trimester pregnancy loss: Clinical implications of genetic testing
- (2016) Diana Massalska et al. JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
- Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
- (2016) Peter Ly et al. NATURE CELL BIOLOGY
- Repair Pathway Choices and Consequences at the Double-Strand Break
- (2016) Raphael Ceccaldi et al. TRENDS IN CELL BIOLOGY
- Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system
- (2016) Maki Morishita et al. Oncotarget
- Immortalization capacity of HPV types is inversely related to chromosomal instability
- (2016) Denise M. Schütze et al. Oncotarget
- Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5
- (2016) Dexiao Yuan et al. Oncotarget
- Chromothripsis in Healthy Individuals Affects Multiple Protein-Coding Genes and Can Result in Severe Congenital Abnormalities in Offspring
- (2015) Mirjam S. de Pagter et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Constitutional chromothripsis involving chromosome 19 in a child with subtle dysmorphic features
- (2015) Jia-Chi Wang et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Chromothripsis: A New Mechanism for Rapid Karyotype Evolution
- (2015) Mitchell L. Leibowitz et al. Annual Review of Genetics
- ChromothripsisDB: a curated database of chromothripsis
- (2015) Jian Yang et al. BIOINFORMATICS
- Linking Micronuclei to Chromosome Fragmentation
- (2015) Emily M. Hatch et al. CELL
- Chromothripsis and Kataegis Induced by Telomere Crisis
- (2015) John Maciejowski et al. CELL
- A germline chromothripsis event stably segregating in 11 individuals through three generations
- (2015) Birgitte Bertelsen et al. GENETICS IN MEDICINE
- Unbalanced translocations arise from diverse mutational mechanisms including chromothripsis
- (2015) Brooke Weckselblatt et al. GENOME RESEARCH
- Chromothripsis in cancer cells: An update
- (2015) Agata Rode et al. INTERNATIONAL JOURNAL OF CANCER
- Radiation-induced changes in DNA methylation and their relationship to chromosome aberrations in nuclear power plant workers
- (2015) Younghyun Lee et al. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
- Chromothripsis with at least 12 breaks at 1p36.33-p35.3 in a boy with multiple congenital anomalies
- (2015) Bruno Faulin Gamba et al. MOLECULAR GENETICS AND GENOMICS
- A cell-based model system links chromothripsis with hyperploidy
- (2015) B. R. Mardin et al. Molecular Systems Biology
- Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia
- (2015) Roberta Meschini et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Stress induced by premature chromatin condensation triggers chromosome shattering and chromothripsis at DNA sites still replicating in micronuclei or multinucleate cells when primary nuclei enter mitosis
- (2015) Georgia I. Terzoudi et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Chromothripsis from DNA damage in micronuclei
- (2015) Cheng-Zhong Zhang et al. NATURE
- Prenatal diagnosis of chromothripsis, with nine breaks characterized by karyotyping, FISH, microarray and whole-genome sequencing
- (2015) M. J. Macera et al. PRENATAL DIAGNOSIS
- Spermatogenesis, DNA damage and DNA repair mechanisms in male infertility
- (2015) Sezgin Gunes et al. REPRODUCTIVE BIOMEDICINE ONLINE
- Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect
- (2015) Shuai Xu et al. RNA Biology
- Constitutional chromothripsis involving the critical region of 9q21.13 microdeletion syndrome
- (2015) Rita Genesio et al. Molecular Cytogenetics
- DNA copy number analysis of Grade II–III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status
- (2015) Adam Cohen et al. Acta Neuropathologica Communications
- Chromothripsis-like patterns are recurring but heterogeneously distributed features in a survey of 22,347 cancer genome screens
- (2014) Haoyang Cai et al. BMC GENOMICS
- Chromosome-breakage genomic instability and chromothripsis in breast cancer
- (2014) Ewa Przybytkowski et al. BMC GENOMICS
- The Architecture and Evolution of Cancer Neochromosomes
- (2014) Dale W. Garsed et al. CANCER CELL
- Genomics of uterine leiomyomas: insights from high-throughput sequencing
- (2014) Miika Mehine et al. FERTILITY AND STERILITY
- Chromothripsis: potential origin in gametogenesis and preimplantation cell divisions. A review
- (2014) Franck Pellestor et al. FERTILITY AND STERILITY
- Loeys–Dietz syndrome type 4, caused by chromothripsis, involving the TGFB2 gene
- (2014) Paolo Fontana et al. GENE
- Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis
- (2014) Zuzana Zemanova et al. LEUKEMIA RESEARCH
- Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
- (2014) Yilong Li et al. NATURE
- Increased L1 Retrotransposition in the Neuronal Genome in Schizophrenia
- (2014) Miki Bundo et al. NEURON
- The elusive evidence for chromothripsis
- (2014) Marcus Kinsella et al. NUCLEIC ACIDS RESEARCH
- Whole-genome sequencing identifies genomic heterogeneity at a nucleotide and chromosomal level in bladder cancer
- (2014) Carl D. Morrison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis
- (2014) Katia Nones et al. Nature Communications
- Genomic and Functional Overlap between Somatic and Germline Chromosomal Rearrangements
- (2014) Sebastiaan van Heesch et al. Cell Reports
- The advantages of SNP arrays over CGH arrays
- (2014) Boris Keren Molecular Cytogenetics
- Cytogenetically normal uterine leiomyomas without MED12-mutations – a source to identify unknown mechanisms of the development of uterine smooth muscle tumors
- (2014) Carsten Holzmann et al. Molecular Cytogenetics
- What Is a Complex Chromosome Rearrangement?
- (2013) Kamlesh Madan AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Punctuated Evolution of Prostate Cancer Genomes
- (2013) Sylvan C. Baca et al. CELL
- Criteria for Inference of Chromothripsis in Cancer Genomes
- (2013) Jan O. Korbel et al. CELL
- Chromothripsis: Breakage-fusion-bridge over and over again
- (2013) Carlos Oscar Sánchez Solorzano et al. CELL CYCLE
- Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming
- (2013) Shinpei Yamaguchi et al. CELL RESEARCH
- Chromothripsis in congenital disorders and cancer: similarities and differences
- (2013) Wigard P Kloosterman et al. CURRENT OPINION IN CELL BIOLOGY
- Chromatin remodeling by the small RNA machinery in mammalian cells
- (2013) Long-Cheng Li Epigenetics
- The strength of combined cytogenetic and mate-pair sequencing techniques illustrated by a germline chromothripsis rearrangement involving FOXP2
- (2013) Lusine Nazaryan et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms
- (2013) A. Malhotra et al. GENOME RESEARCH
- A comparative cytogenetic study of miscarriages after IVF and natural conception in women aged under and over 35 years
- (2013) Anna A. Pendina et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- Male-driven de novo mutations in haploid germ cells
- (2013) M.-C. Gregoire et al. MOLECULAR HUMAN REPRODUCTION
- Characterization of Uterine Leiomyomas by Whole-Genome Sequencing
- (2013) Miika Mehine et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Familial Cri-du-Chat/5p Deletion Syndrome Resulted from Rare Maternal Complex Chromosomal Rearrangements (CCRs) and/or Possible Chromosome 5p Chromothripsis
- (2013) Heng Gu et al. PLoS One
- Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement
- (2013) Ruth N. MacKinnon et al. Cancer Genetics
- Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
- (2013) Lidiya Luzhna et al. Frontiers in Genetics
- Chromothripsis and Human Disease: Piecing Together the Shattering Process
- (2012) Christopher A. Maher et al. CELL
- Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations
- (2012) Tobias Rausch et al. CELL
- Chromothripsis: Chromosomes in Crisis
- (2012) Mathew J.K. Jones et al. DEVELOPMENTAL CELL
- Direct and delayed X-ray-induced DNA damage in male mouse germ cells
- (2012) Eugenia Cordelli et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response
- (2012) Ho Lam Tang et al. MOLECULAR BIOLOGY OF THE CELL
- DNA breaks and chromosome pulverization from errors in mitosis
- (2012) Karen Crasta et al. NATURE
- Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes
- (2012) Jan J. Molenaar et al. NATURE
- Subgroup-specific structural variation across 1,000 medulloblastoma genomes
- (2012) Paul A. Northcott et al. NATURE
- Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration
- (2012) Colby Chiang et al. NATURE GENETICS
- Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements
- (2012) Andrew J Holland et al. NATURE MEDICINE
- Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage
- (2012) Shawn L. Chavez et al. Nature Communications
- Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms
- (2012) Wigard P. Kloosterman et al. Cell Reports
- Cancer Genomes Evolve by Pulverizing Single Chromosomes
- (2011) Matthew Meyerson et al. CELL
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
- (2011) Philip J. Stephens et al. CELL
- Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements
- (2011) Pengfei Liu et al. CELL
- Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
- (2011) Jan Tamminga et al. CELL CYCLE
- Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline†
- (2011) Wigard P. Kloosterman et al. HUMAN MOLECULAR GENETICS
- When catastrophe strikes a cell
- (2011) Jose M. C. Tubio et al. NATURE
- The genomic complexity of primary human prostate cancer
- (2011) Michael F. Berger et al. NATURE
- microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways
- (2010) Olga Kovalchuk et al. CARCINOGENESIS
- Complex chromosome rearrangements:Report of a new case and literature review
- (2010) G. S. Pai et al. CLINICAL GENETICS
- Assembly algorithms for next-generation sequencing data
- (2010) Jason R. Miller et al. GENOMICS
- Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences
- (2009) A. Arpanahi et al. GENOME RESEARCH
- CHROMOSOME DAMAGE ASSOCIATED WITH THE MEASLES VIRUS IN VITRO1
- (2009) WARREN W. NICHOLS et al. HEREDITAS
- Oxidative DNA damage impairs global sperm DNA methylation in infertile men
- (2009) Ozlem Tunc et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
- A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation
- (2009) P. J. Hastings et al. PLoS Genetics
- Chromatin structure influences the sensitivity of DNA to γ-radiation
- (2008) Martin Falk et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded Spleen
- (2008) Igor Koturbash et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Segmental Duplications Arise from Pol32-Dependent Repair of Broken Forks through Two Alternative Replication-Based Mechanisms
- (2008) Celia Payen et al. PLoS Genetics
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