Cytokine therapy reverses NK cell anergy in MHC-deficient tumors

Cutting Edge: Viral Infection Breaks NK Cell Tolerance to "Missing Self"

(2014) J. C. Sun et al.   JOURNAL OF IMMUNOLOGY

Cancer-Expanded Myeloid-Derived Suppressor Cells Induce Anergy of NK Cells through Membrane-Bound TGF- 1

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

NK cell self tolerance, responsiveness and missing self recognition

(2014) Nataliya Shifrin et al.   SEMINARS IN IMMUNOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission

(2012) N. Vey et al.   BLOOD

Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells

(2012) S. Gill et al.   BLOOD

Sustained effector function of IL-12/15/18–preactivated NK cells against established tumors

(2012) Jing Ni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Myeloid Suppressor Cell Depletion Augments Antitumor Activity in Lung Cancer

(2012) Minu K. Srivastava et al.   PLoS One

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells during Tumor Regression

(2010) Jacques Deguine et al.   IMMUNITY

Multiple uses of basement membrane-like matrix (BME/Matrigel) in vitro and in vivo with cancer cells

(2010) Gabriel Benton et al.   INTERNATIONAL JOURNAL OF CANCER

Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment

(2010) Nathalie T. Joncker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells

(2009) F. Romagne et al.   BLOOD

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Depletion of CD4+CD25+regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model

(2009) H. Hong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

In vivotumor cell rejection induced by NK cell inhibitory receptor blockade: Maintained tolerance to normal cells even in the presence of IL-2

(2009) Gustaf Vahlne et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor

(2009) Bastian Hoechst et al.   HEPATOLOGY

NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model

(2009) N. T. Joncker et al.   JOURNAL OF IMMUNOLOGY

Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo

(2009) C. Sola et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine therapy in cancer

(2008) Kim Margolin   EXPERT OPINION ON BIOLOGICAL THERAPY

Regulation of NK cell responsiveness to achieve self-tolerance and maximal responses to diseased target cells

(2008) Nathalie T. Joncker et al.   IMMUNOLOGICAL REVIEWS