Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity

SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation

(2020) Xing Liu et al.   EMBO JOURNAL

Emerging viruses in aquaculture

(2019) Frederick SB Kibenge   Current Opinion in Virology

Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53–MDM2 interaction in a hydroxylase-independent manner

(2019) Yiming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish

(2018) Wuhan Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3 Regulates p53 Protein Stability by Hydroxylating Proline 359

(2018) Javier Rodriguez et al.   Cell Reports

Zebrafish NDRG1a Negatively Regulates IFN Induction by Promoting the Degradation of IRF7

(2018) Long-Feng Lu et al.   JOURNAL OF IMMUNOLOGY

Loss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia

(2017) Angelika Beneke et al.   Cell Death & Disease

Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

(2016) Jian Fu   CELLULAR SIGNALLING

Spring viraemia of carp virus: recent advances

(2016) Usama Ashraf et al.   JOURNAL OF GENERAL VIROLOGY

Zebrafishfoxo3bNegatively Regulates Antiviral Response through Suppressing the Transactivity ofirf3andirf7

(2016) Xing Liu et al.   JOURNAL OF IMMUNOLOGY

Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes

(2016) Hui Feng et al.   JOURNAL OF IMMUNOLOGY

Prolyl hydroxylase 3 (PHD3) expression augments the development of regulatory T cells

(2016) Yogesh Singh et al.   MOLECULAR IMMUNOLOGY

Infectious Diseases Affect Marine Fisheries and Aquaculture Economics

(2015) Kevin D. Lafferty et al.   Annual Review of Marine Science

pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation

(2015) Juan Du et al.   JOURNAL OF IMMUNOLOGY

Depletion of PHD3 protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis

(2015) Liang Xie et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation

(2015) Xing Liu et al.   NUCLEIC ACIDS RESEARCH

Controlling emerging infectious diseases in salmon aquaculture

(2015) J.M. PETTERSEN et al.   REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES

Response of host inflammasomes to viral infection

(2015) I-Yin Chen et al.   TRENDS IN MICROBIOLOGY

Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis

(2014) Bo Hu et al.   DEVELOPMENTAL BIOLOGY

The Von Hippel-Lindau Protein Suppresses Androgen Receptor Activity

(2014) Jing Wang et al.   MOLECULAR ENDOCRINOLOGY

Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases

(2013) Rasheduzzaman Chowdhury et al.   ACS Chemical Biology

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Viral vaccines for bony fish: past, present and future

(2013) Celene Salgado-Miranda et al.   Expert Review of Vaccines

Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays

(2013) Satoshi Ota et al.   GENES TO CELLS

Negative Regulation of Nmi on Virus-Triggered Type I IFN Production by Targeting IRF7

(2013) J. Wang et al.   JOURNAL OF IMMUNOLOGY

EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase   Ubiquitination

(2013) J. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response

(2012) Liang Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

The Prolyl Hydroxylase PHD3 Identifies Proinflammatory Macrophages and Its Expression Is Regulated by Activin A

(2012) M. M. Escribese et al.   JOURNAL OF IMMUNOLOGY

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

(2012) J. Kiss et al.   JOURNAL OF IMMUNOLOGY

Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development

(2012) J. Galindo-Villegas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Guanylate Binding Protein 4 Negatively Regulates Virus-Induced Type I IFN and Antiviral Response by Targeting IFN Regulatory Factor 7

(2011) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7

(2011) F. Sun et al.   JOURNAL OF IMMUNOLOGY

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

The Ubiquitin E3 Ligase RAUL Negatively Regulates Type I Interferon through Ubiquitination of the Transcription Factors IRF7 and IRF3

(2010) Yanxing Yu et al.   IMMUNITY

Characterization of Fish IRF3 as an IFN-Inducible Protein Reveals Evolving Regulation of IFN Response in Vertebrates

(2010) F. Sun et al.   JOURNAL OF IMMUNOLOGY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

(2008) S. Ning et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD