A Revolution toward Gene-Editing Technology and Its Application to Crop Improvement

Conventional and Molecular Techniques from Simple Breeding to Speed Breeding in Crop Plants: Recent Advances and Future Outlook

(2020) Sunny Ahmar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly efficient homology‐directed repair using CRISPR/Cpf1‐geminiviral replicon in tomato

(2020) Tien Van Vu et al.   PLANT BIOTECHNOLOGY JOURNAL

Targeted, efficient sequence insertion and replacement in rice

(2020) Yuming Lu et al.   NATURE BIOTECHNOLOGY

CAFRI‐Rice: CRISPR Applicable Functional Redundancy Inspector to Accelerate Functional Genomics in Rice

(2020) Woo‐Jong Hong et al.   PLANT JOURNAL

CRISPR/Cas9-Mediated Multiply Targeted Mutagenesis in Orange and Purple Carrot Plants

(2019) Zhi-Sheng Xu et al.   MOLECULAR BIOTECHNOLOGY

Efficient Targeted Mutagenesis in Apple and First Time Edition of Pear Using the CRISPR-Cas9 System

(2019) Aurélie Charrier et al.   Frontiers in Plant Science

Technological perspectives for plant breeding

(2019) Ian D. Godwin et al.   THEORETICAL AND APPLIED GENETICS

Technological advances in maize breeding: past, present and future

(2019) Carson Andorf et al.   THEORETICAL AND APPLIED GENETICS

Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9

(2019) Hong-Xia Zhang et al.   MOLECULAR THERAPY

Application and future perspective of CRISPR/Cas9 genome editing in fruit crops

(2019) Junhui Zhou et al.   Journal of Integrative Plant Biology

Application of CRISPR-Cas12a temperature sensitivity for improved genome editing in rice, maize, and Arabidopsis

(2019) Aimee A. Malzahn et al.   BMC BIOLOGY

The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges

(2019) Ismail Eş et al.   BIOTECHNOLOGY ADVANCES

Targeted Mutagenesis of NAC Transcription Factor Gene, OsNAC041, Leading to Salt Sensitivity in Rice

(2019) Wang Bo et al.   Rice Science

Assessment of Cas12a‐mediated gene editing efficiency in plants

(2019) Joan Miquel Bernabé‐Orts et al.   PLANT BIOTECHNOLOGY JOURNAL

CRISPR Cpf1 proteins: structure, function and implications for genome editing

(2019) Fatemeh Safari et al.   Cell and Bioscience

Strategies to Increase On-Target and Reduce Off-Target Effects of the CRISPR/Cas9 System in Plants

(2019) Zahra Hajiahmadi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Application of Cas12a and nCas9-activation-induced cytidine deaminase for genome editing and as a non-sexual strategy to generate homozygous/multiplex edited plants in the allotetraploid genome of tobacco

(2019) Chen-Tran Hsu et al.   PLANT MOLECULAR BIOLOGY

CRISPR-Based Directed Evolution for Crop Improvement

(2019) Haroon Butt et al.   TRENDS IN BIOTECHNOLOGY

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Broad-spectrum resistance to bacterial blight in rice using genome editing

(2019) Ricardo Oliva et al.   NATURE BIOTECHNOLOGY

Red to Brown: An Elevated Anthocyanic Response in Apple Drives Ethylene to Advance Maturity and Fruit Flesh Browning

(2019) Richard V. Espley et al.   Frontiers in Plant Science

Development of Improved Fruit, Vegetable, and Ornamental Crops Using the CRISPR/Cas9 Genome Editing Technique

(2019) Lígia Erpen-Dalla Corte et al.   Plants-Basel

OsPRX2 contributes to stomatal closure and improves potassium deficiency tolerance in rice

(2018) Xiaohui Mao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Generation of new glutinous rice by CRISPR/Cas9-targeted mutagenesis of the Waxy gene in elite rice varieties

(2018) Jinshan Zhang et al.   Journal of Integrative Plant Biology

Multiplex gene editing in rice with simplified CRISPR-Cpf1 and CRISPR-Cas9 systems

(2018) Mugui Wang et al.   Journal of Integrative Plant Biology

Engineering Introns to Express RNA Guides for Cas9- and Cpf1-Mediated Multiplex Genome Editing

(2018) Dan Ding et al.   Molecular Plant

Expanding the Scope of CRISPR/Cpf1-Mediated Genome Editing in Rice

(2018) Shaoya Li et al.   Molecular Plant

Transcriptome-wide comparison of selenium hyperaccumulator and nonaccumulator Stanleya species provides new insight into key processes mediating the hyperaccumulation syndrome

(2018) Jiameng Wang et al.   PLANT BIOTECHNOLOGY JOURNAL

Establishing RNA virus resistance in plants by harnessing CRISPR immune system

(2018) Tong Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Editing of an alpha-kafirin gene family increases digestibility and protein quality in sorghum

(2018) Aixia Li et al.   PLANT PHYSIOLOGY

CRISPR/Cas9-mediated genome editing of the fatty acid desaturase 2 gene in Brassica napus

(2018) Ayako Okuzaki et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Gene editing the phytoene desaturase alleles of Cavendish banana using CRISPR/Cas9

(2018) Fatima Naim et al.   TRANSGENIC RESEARCH

Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells

(2018) Stephan Riesenberg et al.   Nature Communications

Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells

(2018) Xiaojie Ma et al.   Nature Communications

Cas9 versus Cas12a/Cpf1: Structure-function comparisons and implications for genome editing

(2018) Daan C. Swarts et al.   Wiley Interdisciplinary Reviews-RNA

Simultaneous Editing of Two Copies of Gh14-3-3d Confers Enhanced Transgene-Clean Plant Defense Against Verticillium dahliae in Allotetraploid Upland Cotton

(2018) Zhennan Zhang et al.   Frontiers in Plant Science

CRISPR for Crop Improvement: An Update Review

(2018) Deepa Jaganathan et al.   Frontiers in Plant Science

CRISPR/Cas9-Mediated Multiplex Genome Editing of the BnWRKY11 and BnWRKY70 Genes in Brassica napus L.

(2018) Qinfu Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2018) Nicole M. Gaudelli et al.   NATURE

Design of a bacterial speck resistant tomato by CRISPR/Cas9-mediated editing of SlJAZ2

(2018) Andrés Ortigosa et al.   PLANT BIOTECHNOLOGY JOURNAL

Genome editing technologies and their applications in crop improvement

(2018) Rukmini Mishra et al.   Plant Biotechnology Reports

CRISPR-Cpf1-mediated genome editing and gene regulation in human cells

(2018) Tianwen Li et al.   BIOTECHNOLOGY ADVANCES

Speed breeding in growth chambers and glasshouses for crop breeding and model plant research

(2018) Sreya Ghosh et al.   Nature Protocols

Whole genome sequencing reveals rare off-target mutations and considerable inherent genetic or/and somaclonal variations in CRISPR/Cas9-edited cotton plants

(2018) Jianying Li et al.   PLANT BIOTECHNOLOGY JOURNAL

Speed breeding orphan crops

(2018) Tinashe Chiurugwi et al.   THEORETICAL AND APPLIED GENETICS

Back to the future: revisiting MAS as a tool for modern plant breeding

(2018) Joshua N. Cobb et al.   THEORETICAL AND APPLIED GENETICS

Toward the sequence-based breeding in legumes in the post-genome sequencing era

(2018) Rajeev K. Varshney et al.   THEORETICAL AND APPLIED GENETICS

Prospects of pan-genomics in barley

(2018) Cécile Monat et al.   THEORETICAL AND APPLIED GENETICS

The Sorghum QTL Atlas: a powerful tool for trait dissection, comparative genomics and crop improvement

(2018) Emma Mace et al.   THEORETICAL AND APPLIED GENETICS

CRISPR/Cas9-mediated efficient editing in phytoene desaturase (PDS) demonstrates precise manipulation in banana cv. Rasthali genome

(2017) Navneet Kaur et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Greedy or needy? Land use and climate impacts of food in 2050 under different livestock futures

(2017) Elin Röös et al.   GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS

Reduced Drought Tolerance by CRISPR/Cas9-Mediated SlMAPK3 Mutagenesis in Tomato Plants

(2017) Liu Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

High-efficiency breeding of early-maturing rice cultivars via CRISPR/Cas9-mediated genome editing

(2017) Xiufeng Li et al.   Journal of Genetics and Genomics

A retrotransposon in an HKT1 family sodium transporter causes variation of leaf Na+ exclusion and salt tolerance in maize

(2017) Ming Zhang et al.   NEW PHYTOLOGIST

Simultaneous Targeting of Multiple Gene Homeologs to Alter Seed Oil Production in Camelina sativa

(2017) J. A. Aznar-Moreno et al.   PLANT AND CELL PHYSIOLOGY

CRISPR/Cas9-mediated efficient targeted mutagenesis in grape in the first generation

(2017) Xianhang Wang et al.   PLANT BIOTECHNOLOGY JOURNAL

Multiplexed CRISPR/Cas9-mediated metabolic engineering of γ-aminobutyric acid levels in Solanum lycopersicum

(2017) Rui Li et al.   PLANT BIOTECHNOLOGY JOURNAL

Engineering canker-resistant plants through CRISPR/Cas9-targeted editing of the susceptibility gene CsLOB1 promoter in citrus

(2017) Aihong Peng et al.   PLANT BIOTECHNOLOGY JOURNAL

Significant enhancement of fatty acid composition in seeds of the allohexaploid, Camelina sativa , using CRISPR/Cas9 gene editing

(2017) Wen Zhi Jiang et al.   PLANT BIOTECHNOLOGY JOURNAL

CRISPR/Cas9 and TALENs generate heritable mutations for genes involved in small RNA processing of Glycine max and Medicago truncatula

(2017) Shaun J. Curtin et al.   PLANT BIOTECHNOLOGY JOURNAL

Selective gene dosage by CRISPR-Cas9 genome editing in hexaploid Camelina sativa

(2017) Céline Morineau et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of targeted mutant rice using a CRISPR-Cpf1 system

(2017) Rongfang Xu et al.   PLANT BIOTECHNOLOGY JOURNAL

CRISPR/Cas9-mediated targeted mutagenesis of GmFT2a delays flowering time in soya bean

(2017) Yupeng Cai et al.   PLANT BIOTECHNOLOGY JOURNAL

Simultaneous modification of three homoeologs of TaEDR1 by genome editing enhances powdery mildew resistance in wheat

(2017) Yunwei Zhang et al.   PLANT JOURNAL

TALEN-mediated genome-editing approaches in the liverwort Marchantia polymorpha yield high efficiencies for targeted mutagenesis

(2017) Sarah Kopischke et al.   Plant Methods

CRISPR/Cpf1-mediated DNA-free plant genome editing

(2017) Hyeran Kim et al.   Nature Communications

OsSAPK2 Confers Abscisic Acid Sensitivity and Tolerance to Drought Stress in Rice

(2017) Dengji Lou et al.   Frontiers in Plant Science

CRISPR/Cas9-mediated targeted mutagenesis in grape

(2017) Ikuko Nakajima et al.   PLoS One

Rapid generation of a transgene-free powdery mildew resistant tomato by genome deletion

(2017) Vladimir Nekrasov et al.   Scientific Reports

Rapid breeding of parthenocarpic tomato plants using CRISPR/Cas9

(2017) Risa Ueta et al.   Scientific Reports

Precise insertion and guided editing of higher plant genomes using Cpf1 CRISPR nucleases

(2017) Matthew B. Begemann et al.   Scientific Reports

Targeted modification of plant genomes for precision crop breeding

(2016) Julia Hilscher et al.   Biotechnology Journal

High-efficiency CRISPR/Cas9 multiplex gene editing using the glycine tRNA-processing system-based strategy in maize

(2016) Weiwei Qi et al.   BMC BIOTECHNOLOGY

Direct stacking of sequence-specific nuclease-induced mutations to produce high oleic and low linolenic soybean oil

(2016) Zachary L. Demorest et al.   BMC PLANT BIOLOGY

Transcription activator-like effector nucleases (TALENs): An efficient tool for plant genome editing

(2016) Kulbhushan Chaudhary et al.   ENGINEERING IN LIFE SCIENCES

TALEN-Mediated Homologous Recombination Produces Site-Directed DNA Base Change and Herbicide-Resistant Rice

(2016) Ting Li et al.   Journal of Genetics and Genomics

QTL editing confers opposing yield performance in different rice varieties

(2016) Lan Shen et al.   Journal of Integrative Plant Biology

Engineering of CRISPR/Cas9-mediated potyvirus resistance in transgene-freeArabidopsisplants

(2016) Douglas E. Pyott et al.   MOLECULAR PLANT PATHOLOGY

Development of broad virus resistance in non-transgenic cucumber using CRISPR/Cas9 technology

(2016) Jeyabharathy Chandrasekaran et al.   MOLECULAR PLANT PATHOLOGY

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Variation in the flowering gene SELF PRUNING 5G promotes day-neutrality and early yield in tomato

(2016) Sebastian Soyk et al.   NATURE GENETICS

Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci

(2016) Baohui Chen et al.   NUCLEIC ACIDS RESEARCH

Tomato facultative parthenocarpy results from SlAGAMOUS-LIKE 6 loss of function

(2016) Chen Klap et al.   PLANT BIOTECHNOLOGY JOURNAL

ARGOS8 variants generated by CRISPR-Cas9 improve maize grain yield under field drought stress conditions

(2016) Jinrui Shi et al.   PLANT BIOTECHNOLOGY JOURNAL

Genome editing for targeted improvement of plants

(2016) Kiran Khandagale et al.   Plant Biotechnology Reports

Efficient CRISPR/Cas9-based gene knockout in watermelon

(2016) Shouwei Tian et al.   PLANT CELL REPORTS

Efficient targeted multiallelic mutagenesis in tetraploid potato (Solanum tuberosum) by transient CRISPR-Cas9 expression in protoplasts

(2016) Mariette Andersson et al.   PLANT CELL REPORTS

TALEN mediated targeted mutagenesis of the caffeic acid O-methyltransferase in highly polyploid sugarcane improves cell wall composition for production of bioethanol

(2016) Je Hyeong Jung et al.   PLANT MOLECULAR BIOLOGY

AMedicago truncatulaCystathionine-β-Synthase-like Domain-Containing Protein Is Required for Rhizobial Infection and Symbiotic Nitrogen Fixation

(2016) Senjuti Sinharoy et al.   PLANT PHYSIOLOGY

Small RNA changes in synthetic Brassica napus

(2016) Ying Fu et al.   PLANTA

Opportunities for Products of New Plant Breeding Techniques

(2016) Jan G. Schaart et al.   TRENDS IN PLANT SCIENCE

Targeted modification of plant genomes for precision crop breeding

(2016) Julia Hilscher et al.   Biotechnology Journal

The CRISPR/Cas Genome-Editing Tool: Application in Improvement of Crops

(2016) Surender Khatodia et al.   Frontiers in Plant Science

Geminivirus-Mediated Genome Editing in Potato (Solanum tuberosum L.) Using Sequence-Specific Nucleases

(2016) Nathaniel M. Butler et al.   Frontiers in Plant Science

CRISPR/Cas9: A Tool to Circumscribe Cotton Leaf Curl Disease

(2016) Zafar Iqbal et al.   Frontiers in Plant Science

Reassessment of the Four Yield-related Genes Gn1a, DEP1, GS3, and IPA1 in Rice Using a CRISPR/Cas9 System

(2016) Meiru Li et al.   Frontiers in Plant Science

DNA-Free Genetically Edited Grapevine and Apple Protoplast Using CRISPR/Cas9 Ribonucleoproteins

(2016) Mickael Malnoy et al.   Frontiers in Plant Science

Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene OsERF922

(2016) Fujun Wang et al.   PLoS One

Exploiting the CRISPR/Cas9 System for Targeted Genome Mutagenesis in Petunia

(2016) Bin Zhang et al.   Scientific Reports

CRISPR/Cas9-Mediated Immunity to Geminiviruses: Differential Interference and Evasion

(2016) Zahir Ali et al.   Scientific Reports

Efficient targeted mutagenesis of rice and tobacco genomes using Cpf1 from Francisella novicida

(2016) Akira Endo et al.   Scientific Reports

CRISPR/Cas9-mediated mutagenesis of the RIN locus that regulates tomato fruit ripening

(2015) Yasuhiro Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The CRISPR/Cas9 system for plant genome editing and beyond

(2015) Luisa Bortesi et al.   BIOTECHNOLOGY ADVANCES

Meeting the Global Food Demand of the Future by Engineering Crop Photosynthesis and Yield Potential

(2015) Stephen P. Long et al.   CELL

Oligonucleotide-directed mutagenesis for precision gene editing

(2015) Noel J. Sauer et al.   PLANT BIOTECHNOLOGY JOURNAL

Improving cold storage and processing traits in potato through targeted gene knockout

(2015) Benjamin M. Clasen et al.   PLANT BIOTECHNOLOGY JOURNAL

Creation of fragrant rice by targeted knockout of theOsBADH2gene using TALEN technology

(2015) Qiwei Shan et al.   PLANT BIOTECHNOLOGY JOURNAL

Use of designer nucleases for targeted gene and genome editing in plants

(2015) Donald P. Weeks et al.   PLANT BIOTECHNOLOGY JOURNAL

A multiplex CRISPR/Cas9 platform for fast and efficient editing of multiple genes in Arabidopsis

(2015) Zhengjing Zhang et al.   PLANT CELL REPORTS

Generation of inheritable and “transgene clean” targeted genome-modified rice in later generations using the CRISPR/Cas9 system

(2015) Rong-Fang Xu et al.   Scientific Reports

Establishing a CRISPR–Cas-like immune system conferring DNA virus resistance in plants

(2015) Xiang Ji et al.   Nature Plants

Conferring resistance to geminiviruses with the CRISPR–Cas prokaryotic immune system

(2015) Nicholas J. Baltes et al.   Nature Plants

Efficient CRISPR/Cas9-mediated Targeted Mutagenesis in Populus in the First Generation

(2015) Di Fan et al.   Scientific Reports

The CRISPR–Cas system for plant genome editing: advances and opportunities

(2014) Vinay Kumar et al.   JOURNAL OF EXPERIMENTAL BOTANY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew

(2014) Yanpeng Wang et al.   NATURE BIOTECHNOLOGY

Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice

(2014) Huanbin Zhou et al.   NUCLEIC ACIDS RESEARCH

Classification and evolution of type II CRISPR-Cas systems

(2014) Krzysztof Chylinski et al.   NUCLEIC ACIDS RESEARCH

The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation

(2014) Hui Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

CRISPR/Cas9-mediated targeted mutagenesis in Nicotiana tabacum

(2014) Junping Gao et al.   PLANT MOLECULAR BIOLOGY

Targeted Mutagenesis of the Tomato PROCERA Gene Using Transcription Activator-Like Effector Nucleases

(2014) V. S. Lor et al.   PLANT PHYSIOLOGY

Efficient Gene Editing in Tomato in the First Generation Using the Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-Associated9 System

(2014) C. Brooks et al.   PLANT PHYSIOLOGY

Site-directed mutagenesis in Arabidopsis thaliana using dividing tissue-targeted RGEN of the CRISPR/Cas system to generate heritable null alleles

(2014) Youbong Hyun et al.   PLANTA

Targeted Genome Editing of Sweet Orange Using Cas9/sgRNA

(2014) Hongge Jia et al.   PLoS One

Identification of “safe harbor” loci in indica rice genome by harnessing the property of zinc-finger nucleases to induce DNA damage and repair

(2014) Christian Cantos et al.   Frontiers in Plant Science

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

(2013) Albert W Cheng et al.   CELL RESEARCH

Application of the CRISPR–Cas System for Efficient Genome Engineering in Plants

(2013) Yanfei Mao et al.   Molecular Plant

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease

(2013) Seung Woo Cho et al.   NATURE BIOTECHNOLOGY

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

(2013) Jian-Feng Li et al.   NATURE BIOTECHNOLOGY

Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease

(2013) Vladimir Nekrasov et al.   NATURE BIOTECHNOLOGY

Directed evolution of the TALE N-terminal domain for recognition of all 5′ bases

(2013) Brian M. Lamb et al.   NUCLEIC ACIDS RESEARCH

Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice

(2013) Wenzhi Jiang et al.   NUCLEIC ACIDS RESEARCH

Trait stacking via targeted genome editing

(2013) William M. Ainley et al.   PLANT BIOTECHNOLOGY JOURNAL

Targeted molecular trait stacking in cotton through targeted double-strand break induction

(2013) Kathleen D'Halluin et al.   PLANT BIOTECHNOLOGY JOURNAL

Male-sterile maize plants produced by targeted mutagenesis of the cytochrome P450-like gene (MS26) using a re-designed I-CreI homing endonuclease

(2013) Vesna Djukanovic et al.   PLANT JOURNAL

Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system

(2013) Khaoula Belhaj et al.   Plant Methods

Yield Trends Are Insufficient to Double Global Crop Production by 2050

(2013) Deepak K. Ray et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

RNA-Guided Genome Editing for Target Gene Mutations in Wheat

(2013) Santosh Kumar Upadhyay et al.   G3-Genes Genomes Genetics

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

High-efficiency TALEN-based gene editing produces disease-resistant rice

(2012) Ting Li et al.   NATURE BIOTECHNOLOGY

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

(2012) Thomas Gaj et al.   NATURE METHODS

Transcriptional activation ofBrassica napusβ-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor

(2012) Manju Gupta et al.   PLANT BIOTECHNOLOGY JOURNAL

ZFN-mediated gene targeting of the Arabidopsisprotoporphyrinogen oxidasegene throughAgrobacterium-mediated floral dip transformation

(2012) Sylvia de Pater et al.   PLANT BIOTECHNOLOGY JOURNAL

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

(2012) G. Gasiunas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Targeting DNA With Fingers and TALENs

(2012) Daniel F Carlson et al.   Molecular Therapy-Nucleic Acids

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Evolution and classification of the CRISPR–Cas systems

(2011) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

(2011) Claudio Mussolino et al.   NUCLEIC ACIDS RESEARCH

Targeted Mutagenesis of Duplicated Genes in Soybean with Zinc-Finger Nucleases

(2011) S. J. Curtin et al.   PLANT PHYSIOLOGY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Zinc finger nuclease-mediated transgene deletion

(2010) Joseph F. Petolino et al.   PLANT MOLECULAR BIOLOGY

High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases

(2010) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases

(2010) K. Osakabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linking the emergence of fungal plant diseases with ecological speciation

(2010) Tatiana Giraud et al.   TRENDS IN ECOLOGY & EVOLUTION

High-frequency modification of plant genes using engineered zinc-finger nucleases

(2009) Jeffrey A. Townsend et al.   NATURE

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

(2009) Vipula K. Shukla et al.   NATURE

Mre11: roles in DNA repair beyond homologous recombination

(2009) Shan Zha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY

Construction of a fosmid library of cucumber (Cucumis sativus) and comparative analyses of the eIF4E and eIF(iso)4E regions from cucumber and melon (Cucumis melo)

(2008) J. D. F. Meyer et al.   MOLECULAR GENETICS AND GENOMICS

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

(2008) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH