标题
Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 15, Pages 5207
出版商
MDPI AG
发表日期
2020-07-23
DOI
10.3390/ijms21155207
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mifamurtide and TAM-like macrophages: effect on proliferation, migration and differentiation of osteosarcoma cells
- (2020) Francesca Punzo et al. Oncotarget
- The efficacy and safety comparison of first-line chemotherapeutic agents (high-dose methotrexate, doxorubicin, cisplatin, and ifosfamide) for osteosarcoma: a network meta-analysis
- (2020) Bin Zhang et al. Journal of Orthopaedic Surgery and Research
- Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer
- (2020) Min Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Human chimeric antigen receptor macrophages for cancer immunotherapy
- (2020) Michael Klichinsky et al. NATURE BIOTECHNOLOGY
- Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in Patients With Osteosarcoma
- (2020) Lisa Mirabello et al. JAMA Oncology
- The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
- (2020) Isabelle Corre et al. Cells
- Prognostic Significance of β-Catenin Expression in Osteosarcoma: A Meta-Analysis
- (2020) Xiaoliang Xie et al. Frontiers in Oncology
- Macrophages reduce the sensitivity of osteosarcoma to neoadjuvant chemotherapy drugs by secreting Interleukin-1 beta
- (2020) Xin Liang et al. CANCER LETTERS
- Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis
- (2020) Emanuele Giurisato et al. CANCER RESEARCH
- WNT/β-catenin pathway activation correlates with immune exclusion across human cancers
- (2019) Jason J. Luke et al. CLINICAL CANCER RESEARCH
- IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer
- (2019) Li Yang et al. INTERNATIONAL JOURNAL OF CANCER
- Inhibition of M2-like macrophages by all-trans retinoic acid prevents cancer initiation and stemness in osteosarcoma cells
- (2019) Xue-jing Shao et al. ACTA PHARMACOLOGICA SINICA
- Osteosarcoma cell-derived exosomes affect tumor microenvironment by specific packaging of microRNAs
- (2019) Lavinia Raimondi et al. CARCINOGENESIS
- What’s new in bone forming tumours of the skeleton?
- (2019) Natasja Franceschini et al. VIRCHOWS ARCHIV
- The Emerging Roles of Extracellular Vesicles in Osteosarcoma
- (2019) Francesca Perut et al. Frontiers in Oncology
- Signalling mechanism(s) of epithelial–mesenchymal transition and cancer stem cells in tumour therapeutic resistance
- (2018) Zhihong Cai et al. CLINICA CHIMICA ACTA
- Combined analysis of DNA methylation and gene expression profiles of osteosarcoma identified several prognosis signatures
- (2018) Wen Tian et al. GENE
- Comparison of Tumor- and Bone Marrow-Derived Mesenchymal Stromal/Stem Cells from Patients with High-Grade Osteosarcoma
- (2018) Louis-Romée Le Nail et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Novel smoothened antagonists as anti-neoplastic agents for the treatment of osteosarcoma
- (2018) Giulia Bernardini et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition
- (2018) Emanuele Giurisato et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Anti-PD-1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases
- (2018) Pooja Dhupkar et al. Cancer Medicine
- Osteosarcoma in patients below 25�years of age: An observational study of incidence, metastasis, treatment and outcomes
- (2018) Zhigang Nie et al. Oncology Letters
- Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis
- (2018) Yu Han et al. CANCER LETTERS
- Cancer stem cells (CSCs) in cancer progression and therapy
- (2018) Masoud Najafi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Macrophage-derived CCL18 promotes osteosarcoma proliferation and migration by upregulating the expression of UCA1
- (2018) Yang Su et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Exosomes from Osteosarcoma and normal osteoblast differ in proteomic cargo and immunomodulatory effects on T cells
- (2017) Ryan M. Troyer et al. EXPERIMENTAL CELL RESEARCH
- Tim3/Gal9 interactions between T cells and monocytes result in an immunosuppressive feedback loop that inhibits Th1 responses in osteosarcoma patients
- (2017) Xiuzhong Li et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Mesenchymal stem cells: key players in cancer progression
- (2017) Sarah M. Ridge et al. Molecular Cancer
- Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy
- (2017) D. Matthew Gianferante et al. Nature Reviews Endocrinology
- Patterns of PD-1, PD-L1, and PD-L2 expression in pediatric solid tumors
- (2017) Navin Pinto et al. PEDIATRIC BLOOD & CANCER
- Nanoparticles and innate immunity: new perspectives on host defence
- (2017) Diana Boraschi et al. SEMINARS IN IMMUNOLOGY
- Expression and clinical association of programmed cell death-1, programmed death-ligand-1 and CD8+ lymphocytes in primary sarcomas is subtype dependent
- (2017) Anke E.M. van Erp et al. Oncotarget
- Prognostic value of programmed death-ligand 1 in sarcoma: a meta-analysis
- (2017) Zhenhua Zhu et al. Oncotarget
- All-Trans Retinoic Acid Prevents Osteosarcoma Metastasis by Inhibiting M2 Polarization of Tumor-Associated Macrophages
- (2017) Qian Zhou et al. Cancer Immunology Research
- CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial
- (2017) Anne Gomez-Brouchet et al. OncoImmunology
- Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy
- (2016) Yayan T. Sundara et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tie2 Expression on Macrophages Is Required for Blood Vessel Reconstruction and Tumor Relapse after Chemotherapy
- (2016) Lin Chen et al. CANCER RESEARCH
- Future directions in the treatment of osteosarcoma
- (2016) Michael W. Bishop et al. CURRENT OPINION IN PEDIATRICS
- Drugs in early clinical development for the treatment of osteosarcoma
- (2016) Marie-Françoise Heymann et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- p16 expression as a prognostic and predictive marker in high-grade localized osteosarcoma of the extremities: an analysis of 357 cases
- (2016) Alberto Righi et al. HUMAN PATHOLOGY
- CD163 + M2-type tumor-associated macrophage support the suppression of tumor-infiltrating T cells in osteosarcoma
- (2016) Qinglin Han et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Multimodal transfer of MDR by exosomes in human osteosarcoma
- (2016) ELENA TORREGGIANI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Telangiectatic osteosarcoma: a review of 87 cases
- (2016) Andrea Angelini et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Cancer Stem Cells and Macrophages: Implications in Tumor Biology and Therapeutic Strategies
- (2016) Bruno Sainz et al. MEDIATORS OF INFLAMMATION
- PI3Kγ is a molecular switch that controls immune suppression
- (2016) Megan M. Kaneda et al. NATURE
- The development and maintenance of resident macrophages
- (2016) Elisa Gomez Perdiguero et al. NATURE IMMUNOLOGY
- Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues
- (2016) Saeid Zanganeh et al. Nature Nanotechnology
- Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
- (2016) Margherita Cortini et al. PLoS One
- Specification of tissue-resident macrophages during organogenesis
- (2016) E. Mass et al. SCIENCE
- P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development
- (2016) T Velletri et al. Cell Death & Disease
- Dysregulation of macrophage polarization is associated with the metastatic process in osteosarcoma
- (2016) Clotilde Dumars et al. Oncotarget
- Activation of mesenchymal stem cells by macrophages promotes tumor progression through immune suppressive effects
- (2016) Xiao-hua Jia et al. Oncotarget
- Mesenchymal stem cells promote osteosarcoma cell survival and drug resistance through activation of STAT3
- (2016) Bing Tu et al. Oncotarget
- Prognostic value of inflammation-based scores in patients with osteosarcoma
- (2016) Bangjian Liu et al. Scientific Reports
- The Prognostic Role of Ezrin and HER2/neu Expression in Osteosarcoma
- (2016) Asmaa G. Abdou et al. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
- Osteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted Therapies
- (2016) Ander Abarrategi et al. Stem Cells International
- Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages
- (2015) C. Frankenberger et al. CANCER RESEARCH
- PI3K/Akt signaling in osteosarcoma
- (2015) Jian Zhang et al. CLINICA CHIMICA ACTA
- Predictive properties of DNA methylation patterns in primary tumor samples for osteosarcoma relapse status
- (2015) Jeremy M Rosenblum et al. Epigenetics
- Antitumor and antimetastatic actions of dihydroxycoumarins (esculetin or fraxetin) through the inhibition of M2 macrophage differentiation in tumor-associated macrophages and/or G1 arrest in tumor cells
- (2015) Yoshiyuki Kimura et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages
- (2015) Guillaume Hoeffel et al. IMMUNITY
- Macrophages Promote Osteoblastic Differentiation In Vivo: Implications in Fracture Repair and Bone Homeostasis
- (2015) Linda Vi et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Establishment of Four New Human Primary Cell Cultures from Chemo-Naïve Italian Osteosarcoma Patients
- (2015) Marcella Laschi et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions
- (2015) Danielle M. Lussier et al. JOURNAL OF IMMUNOTHERAPY
- A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
- (2015) Branden S Moriarity et al. NATURE GENETICS
- NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma
- (2015) S Zhao et al. ONCOGENE
- Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
- (2015) Michal Kovac et al. Nature Communications
- Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA
- (2015) A. S. Harney et al. Cancer Discovery
- Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells
- (2015) Changbao Chen et al. Oncotarget
- CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study
- (2015) Benedikt Fritzsching et al. OncoImmunology
- Tumor-associated macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial–mesenchymal transition in hepatocellular carcinoma
- (2014) Qing-Min Fan et al. CANCER LETTERS
- Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
- (2014) Slava Epelman et al. IMMUNITY
- Macrophage heterogeneity in tissues: phenotypic diversity and functions
- (2014) Siamon Gordon et al. IMMUNOLOGICAL REVIEWS
- Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment
- (2014) Aude I. Ségaliny et al. INTERNATIONAL JOURNAL OF CANCER
- Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ
- (2014) Jens HW Pahl et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo
- (2014) M. K. Chang et al. JOURNAL OF IMMUNOLOGY
- Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone
- (2014) S. W. Cho et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
- (2014) P. Chaturvedi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma
- (2014) Jennifer A. Perry et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cellular and molecular origin of tumor-associated macrophages
- (2014) R. A. Franklin et al. SCIENCE
- Extracellular Membrane Vesicles Derived from 143B Osteosarcoma Cells Contain Pro-Osteoclastogenic Cargo: A Novel Communication Mechanism in Osteosarcoma Bone Microenvironment
- (2014) Rama Garimella et al. Translational Oncology
- Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
- (2014) Simon Junankar et al. Cancer Discovery
- Programmed Cell Death Ligand 1 Expression in Osteosarcoma
- (2014) J. K. Shen et al. Cancer Immunology Research
- Involvement and targeted intervention of dysregulated Hedgehog signaling in osteosarcoma
- (2013) Winnie W. Lo et al. CANCER
- Osteosarcoma cells promote the production of pro-tumor cytokines in mesenchymal stem cells by inhibiting their osteogenic differentiation through the TGF-β/Smad2/3 pathway
- (2013) Bing Tu et al. EXPERIMENTAL CELL RESEARCH
- Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
- (2013) Claudia Jakubzick et al. IMMUNITY
- Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
- (2013) Daigo Hashimoto et al. IMMUNITY
- Extracellular vesicles: Exosomes, microvesicles, and friends
- (2013) Graça Raposo et al. JOURNAL OF CELL BIOLOGY
- Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF
- (2013) Martin Guilliams et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Macrophage phenotypes during tissue repair
- (2013) Margaret L. Novak et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Macrophages in multiple myeloma: emerging concepts and therapeutic implications
- (2013) Fotis Asimakopoulos et al. LEUKEMIA & LYMPHOMA
- CXCR4-mediated osteosarcoma growth and pulmonary metastasis is promoted by mesenchymal stem cells through VEGF
- (2013) PENG ZHANG et al. ONCOLOGY REPORTS
- Correction: Mesenchymal Stem Cell Transition to Tumor-Associated Fibroblasts Contributes to Fibrovascular Network Expansion and Tumor Progression
- (2013) Erika L. Spaeth et al. PLoS One
- Cord Blood-Derived Macrophage-Lineage Cells Rapidly Stimulate Osteoblastic Maturation in Mesenchymal Stem Cells in a Glycoprotein-130 Dependent Manner
- (2013) Tania J. Fernandes et al. PLoS One
- B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis
- (2013) Ling Wang et al. PLoS One
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- Retinoic acid represses invasion and stem cell phenotype by induction of the metastasis suppressors RARRES1 and LXN
- (2013) E E Oldridge et al. Oncogenesis
- The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis
- (2012) Liliana Endo-Munoz et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
- (2012) J. B. Mitchem et al. CANCER RESEARCH
- Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
- (2012) Simon Yona et al. IMMUNITY
- Macrophage plasticity and polarization: in vivo veritas
- (2012) Antonio Sica et al. JOURNAL OF CLINICAL INVESTIGATION
- Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation
- (2012) Vicky Nicolaidou et al. PLoS One
- A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
- (2012) C. Schulz et al. SCIENCE
- Induction of Osteogenesis in Mesenchymal Stem Cells by Activated Monocytes/Macrophages Depends on Oncostatin M Signaling
- (2012) Pierre Guihard et al. STEM CELLS
- Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway
- (2012) Jian Yang et al. STEM CELLS
- Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs
- (2011) Qing Chen et al. CANCER CELL
- Tumor-Infiltrating Macrophages Are Associated with Metastasis Suppression in High-Grade Osteosarcoma: A Rationale for Treatment with Macrophage Activating Agents
- (2011) E. P. Buddingh et al. CLINICAL CANCER RESEARCH
- Regulators of macrophage activation
- (2011) Fernando O. Martinez EUROPEAN JOURNAL OF IMMUNOLOGY
- Mifamurtide for the treatment of nonmetastatic osteosarcoma
- (2011) Kosei Ando et al. EXPERT OPINION ON PHARMACOTHERAPY
- Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo
- (2011) Virginia Tirino et al. FASEB JOURNAL
- Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
- (2010) I. G. Winkler et al. BLOOD
- Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
- (2010) Scott A. Bergfeld et al. CANCER AND METASTASIS REVIEWS
- CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
- (2010) Amit S. Adhikari et al. CANCER RESEARCH
- Mesenchymal stromal cells from primary osteosarcoma are non-malignant and strikingly similar to their bone marrow counterparts
- (2010) Jan C. Brune et al. INTERNATIONAL JOURNAL OF CANCER
- Smoothened as a new therapeutic target for human osteosarcoma
- (2010) Masataka Hirotsu et al. Molecular Cancer
- Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
- (2010) Subhra K Biswas et al. NATURE IMMUNOLOGY
- Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma
- (2010) X Guo et al. ONCOGENE
- Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance
- (2010) Honoki ONCOLOGY REPORTS
- A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships
- (2009) F. Pucci et al. BLOOD
- Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma
- (2009) Alexander J. Chou et al. CANCER
- Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis
- (2009) Wen-ting Xu et al. CANCER LETTERS
- Zoledronic Acid Inhibits Both the Osteolytic and Osteoblastic Components of Osteosarcoma Lesions in a Mouse Model
- (2009) A. Labrinidis et al. CLINICAL CANCER RESEARCH
- Zoledronic acid modulates antitumoral responses of prostate cancer-tumor associated macrophages
- (2008) Panagiotis Tsagozis et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group
- (2008) Paul A. Meyers et al. JOURNAL OF CLINICAL ONCOLOGY
- Macrophage activation and polarization
- (2007) Fernando Oneissi Martinez Frontiers in Bioscience-Landmark
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search