Nutraceutical Compounds Targeting Inflammasomes in Human Diseases

Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats

(2020) Quanxin Ma et al.   MOLECULES

Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2020) Yanyan Zhu et al.   PHARMACOLOGICAL RESEARCH

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

(2020) Jin-Feng Teng et al.   Cancers

Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein

(2020) Nanjaiah Lalitha et al.   PLoS One

Docosahexaenoic acid inhibits both NLRP3 inflammasome assembly and JNK-mediated mature IL-1β secretion in 5-fluorouracil-treated MDSC: implication in cancer treatment

(2019) Adélie Dumont et al.   Cell Death & Disease

Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell

(2019) Mingjiang Yao et al.   BMC Complementary and Alternative Medicine

Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1

(2019) Jiasi Wu et al.   PHARMACOLOGICAL RESEARCH

Huaier extract suppresses non‐small cell lung cancer progression through activating NLRP3‐dependent pyroptosis

(2019) Jun Xie et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The active components derived from Penthorum chinense Pursh protect against oxidative-stress-induced vascular injury via autophagy induction

(2019) Xiaolei Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice

(2018) Xiya Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Natural products with anti-aging potential: Affected targets and molecular mechanisms

(2018) Cristina-Sorina Cătană et al.   BIOTECHNOLOGY ADVANCES

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Beneficial Properties of Phytochemicals on NLRP3 Inflammasome-Mediated Gout and Complication

(2018) Jhih-Jia Jhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer’s Disease in APP/PS1 Double-Transgenic Mice

(2018) Hongxia Che et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation

(2018) Hailong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fenofibrate improves renal function by amelioration of NOX-4, IL-18, and p53 expression in an experimental model of diabetic nephropathy

(2018) Habib Yaribeygi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice

(2018) Mei-Jun Zhu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns

(2018) Luis E. Pavillard et al.   PHARMACOLOGICAL RESEARCH

Flavonoids interfere with NLRP3 inflammasome activation

(2018) Hyun Lim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antitumor activities of Quercetin and Green Tea in xenografts of human leukemia HL60 cells

(2018) Andrana Karla Calgarotto et al.   Scientific Reports

Vitamin D3 Protects against Diabetic Retinopathy by Inhibiting High-Glucose-Induced Activation of the ROS/TXNIP/NLRP3 Inflammasome Pathway

(2018) Li Lu et al.   Journal of Diabetes Research

2018 ESC/ESH Guidelines for the management of arterial hypertension

(2018) Bryan Williams et al.   EUROPEAN HEART JOURNAL

Curcumin and allopurinol ameliorate fructose-induced hepatic inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome inhibition

(2018) Xiao-Qing Ding et al.   PHARMACOLOGICAL RESEARCH

Anthocyanin is Involved in the Activation of Pyroptosis in Oral Squamous Cell Carcinoma

(2018) Er Yue et al.   PHYTOMEDICINE

Role of the NLRP3 inflammasome in cancer

(2018) Maryam Moossavi et al.   Molecular Cancer

Salvianolate reduces atrial fibrillation through suppressing atrial interstitial fibrosis by inhibiting TGF-β1/Smad2/3 and TXNIP/NLRP3 inflammasome signaling pathways in post-MI rats

(2018) Huiliang Qiu et al.   PHYTOMEDICINE

Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages

(2018) Pauline Chalons et al.   Nutrients

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium

(2017) Xiaoshan Xu et al.   EUROPEAN JOURNAL OF NUTRITION

Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats

(2017) Chang Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ginsenoside Rg1 protects against neuronal degeneration induced by chronic dexamethasone treatment by inhibiting NLRP-1 inflammasomes in mice

(2017) Yaodong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

(2017) Zahra Hoseini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Resolution of inflammation, n − 3 fatty acid supplementation and Alzheimer disease: A narrative review

(2017) Vanessa Gomes Fraga et al.   JOURNAL OF NEUROIMMUNOLOGY

The protective effect of umbelliferone ameliorates myocardial injury following ischemia‑reperfusion in the rat through suppression NLRP3 inflammasome and upregulating the PPAR-γ

(2017) Hongbo Luo et al.   Molecular Medicine Reports

Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms

(2017) Min Li et al.   NEUROSCIENCE LETTERS

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

Isorhamnetin and hyperoside derived from water dropwort inhibits inflammasome activation

(2017) Huijeong Ahn et al.   PHYTOMEDICINE

Curcumin Ameliorates Diabetic Nephropathy by Suppressing NLRP3 Inflammasome Signaling

(2017) Miaomiao Lu et al.   Biomed Research International

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

(2017) Carlos de Torre-Minguela et al.   Frontiers in Immunology

Quercetin Inhibits Inflammasome Activation by Interfering with ASC Oligomerization and Prevents Interleukin-1 Mediated Mouse Vasculitis

(2017) Talita P. Domiciano et al.   Scientific Reports

Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells

(2016) Shaowei Zhuang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain

(2016) Ruipeng Li et al.   BEHAVIOURAL BRAIN RESEARCH

Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice

(2016) Hyeyoon Eo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The inflammasome as a target for pain therapy

(2016) H. Zhang et al.   BRITISH JOURNAL OF ANAESTHESIA

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

(2016) Jing Qiu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Pathogenic Role of NLRP3 Inflammasome Activation in Inflammatory Bowel Diseases of Both Mice and Humans

(2016) Ling Liu et al.   Journal of Crohns & Colitis

Cepharanthine and Piperine ameliorate diabetic nephropathy in rats: role of NF-κB and NLRP3 inflammasome

(2016) Yara A. Samra et al.   LIFE SCIENCES

Resveratrol Protects against Sepsis-Associated Encephalopathy and Inhibits the NLRP3/IL-1βAxis in Microglia

(2016) Da-ming Sui et al.   MEDIATORS OF INFLAMMATION

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

Protective effect of different flavonoids against endothelial senescence via NLRP3 inflammasome

(2016) Chunhui Sun et al.   Journal of Functional Foods

Resveratrol and Cardiovascular Diseases

(2016) Dominique Bonnefont-Rousselot   Nutrients

Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue

(2016) Weijie Chen et al.   Journal of Ginseng Research

Curcumin Represses NLRP3 Inflammasome Activation via TLR4/MyD88/NF-κB and P2X7R Signaling in PMA-Induced Macrophages

(2016) Fanqi Kong et al.   Frontiers in Pharmacology

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats

(2016) Chunchun Ding et al.   Scientific Reports

Parthenolide inhibits LPS-induced inflammatory cytokines through the toll-like receptor 4 signal pathway in THP-1 cells

(2015) S. Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Nutraceuticals and Functional Foods: The Foods for the Future World

(2015) Khalid Gul et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment

(2015) Zu Yue Deng et al.   INFLAMMATION RESEARCH

Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome

(2015) Qinghua Hu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome

(2015) Chunhui Sun et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Umbelliferone ameliorates cerebral ischemia–reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome

(2015) Xiangxiang Wang et al.   NEUROSCIENCE LETTERS

Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner

(2015) Yi Li et al.   PHARMACOLOGICAL RESEARCH

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

(2015) Ying Li et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Genipin inhibits NLRP3 and NLRC4 inflammasome activation via autophagy suppression

(2015) Shui-Xing Yu et al.   Scientific Reports

Colchicine Acutely Suppresses Local Cardiac Production of Inflammatory Cytokines in Patients With an Acute Coronary Syndrome

(2015) Gonzalo J. Martínez et al.   Journal of the American Heart Association

NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

(2015) Amna Abderrazak et al.   Redox Biology

Curcumin: A Double Hit on Malignant Mesothelioma

(2014) J. M. Miller et al.   Cancer Prevention Research

Korean red ginseng extracts inhibit NLRP3 and AIM2 inflammasome activation

(2014) Jeeyoung Kim et al.   IMMUNOLOGY LETTERS

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Scropolioside B Inhibits IL-1βand Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways

(2014) Tiantian Zhu et al.   MEDIATORS OF INFLAMMATION

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

A new flavanone from the aerial parts ofPenthorum chinense

(2014) Meng Wang et al.   NATURAL PRODUCT RESEARCH

Pharmacological potential of tocotrienols: a review

(2014) Haseeb Ahsan et al.   Nutrition & Metabolism

Luteoloside Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Inhibition of NLRP3 Inflammasome

(2014) Shao-hua Fan et al.   PLoS One

Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

Emerging Principles Governing Signal Transduction by Pattern-Recognition Receptors: Table 1.

(2014) Jonathan C. Kagan et al.   Cold Spring Harbor Perspectives in Biology

Inflammasomes

(2014) M. R. de Zoete et al.   Cold Spring Harbor Perspectives in Biology

Triterpenoid-Rich Fraction from Ilex hainanensis Merr. Attenuates Non-Alcoholic Fatty Liver Disease Induced by High Fat Diet in Rats

(2013) Wei-Xi Cui et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

(2013) Wei Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

NLRP3 Inflammasomes Show High Expression in Aorta of Patients with Atherosclerosis

(2013) Fei Zheng et al.   Heart Lung and Circulation

Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

(2013) Yiqing Yan et al.   IMMUNITY

Interleukin-17–producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

(2013) Hye Young Kim et al.   NATURE MEDICINE

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Molecular mechanisms of curcumin action: Gene expression

(2012) Shishir Shishodia   BIOFACTORS

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

(2012) M. T. Chow et al.   CANCER RESEARCH

Autophagy Links Inflammasomes to Atherosclerotic Progression

(2012) Babak Razani et al.   Cell Metabolism

Anti-Inflammatory Iridoids of Botanical Origin

(2012) A. Viljoen et al.   CURRENT MEDICINAL CHEMISTRY

Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside

(2012) Sae-Kwang Ku et al.   FOOD AND CHEMICAL TOXICOLOGY

Screening and identification of the antibacterial bioactive compounds from Lonicera japonica Thunb. leaves

(2012) Jianhua Xiong et al.   FOOD CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

(2012) Danielle Swanson et al.   Advances in Nutrition

Green tea polyphenol epigallocatechin-3-gallate suppresses melanoma growth by inhibiting inflammasome and IL-1β secretion

(2011) Lixia Z. Ellis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats

(2011) ShreyaS Shah et al.   INDIAN JOURNAL OF PHARMACOLOGY

Protective effects of cynaroside against H2O2-induced apoptosis in H9c2 cardiomyoblasts

(2011) Xiao Sun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Anti-Inflammatory and Analgesic Effects of the Aqueous Extract of Corni Fructus in Murine RAW 264.7 Macrophage Cells

(2009) Yun-Hee Sung et al.   JOURNAL OF MEDICINAL FOOD

Diet-Related Disease, Nutritional Genomics, and Food and Nutrition Professionals

(2009) Ruth DeBusk   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

A DNA barcode for land plants

(2009) et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA