Review
Medicine, General & Internal
Sam M. Janes, Doraid Alrifai, Dean A. Fennell
Summary: Mesothelioma, mostly caused by asbestos exposure, has a decreasing incidence but high mortality due to late diagnosis and treatment resistance. Pemetrexed-cisplatin and immune checkpoint inhibitors have shown modest survival extension.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Food Science & Technology
Monica Benvenuto, Daniela Nardozi, Camilla Palumbo, Chiara Focaccetti, Raffaele Carrano, Valentina Angiolini, Loredana Cifaldi, Valeria Lucarini, Patrizia Mancini, Bora Kerpi, Walter Currenti, Roberto Bei, Laura Masuelli
Summary: This study evaluated the enhanced effect of Curcumin (CUR) on targeted therapy for malignant mesothelioma (MM) by using cell lines cultured in vitro and mice bearing intraperitoneally transplanted MM cells. The combination of AFA + CUR had a stronger inhibitory effect on MM progression compared to individual compounds, which might be attributed to increased tumor cell growth inhibition or enhanced pro-apoptotic effect.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Review
Oncology
Melanie Vogl, Anna Rosenmayr, Tomas Bohanes, Axel Scheed, Milos Brndiar, Elisabeth Stubenberger, Bahil Ghanim
Summary: Malignant pleural mesothelioma (MPM) is an aggressive disease with limited treatment options and poor prognosis, with asbestos exposure and chronic inflammation as main risk factors. The suppression of the specific immune system and activation of the innate immune system are crucial drivers of MPM aggressiveness, leading to unfavorable patient outcomes. Identifying new biomarkers can help personalize patient therapy, avoid ineffective treatments, and ultimately improve outcomes in this rare disease.
Article
Biotechnology & Applied Microbiology
Valeria Panzetta, Ida Musella, Sabato Fusco, Paolo A. Netti
Summary: Malignant pleural mesothelioma is a rare but devastating tumor that is difficult to diagnose and treat effectively. Effusion cytology, although used for diagnosis, is time-consuming and has limited sensitivity. Therefore, alternative research methods are needed to support early diagnosis. Mechanobiology offers new perspectives and diagnostic tools for the mechanical and biophysical characterization of malignant pleural mesothelioma cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biology
Alex Di Genova, Lise Mangiante, Alexandra Sexton-Oates, Catherine Voegele, Lynnette Fernandez-Cuesta, Nicolas Alcala, Matthieu Foll
Summary: In the context of the MESOMICS project, this study provided the most comprehensive molecular characterization of malignant pleural mesothelioma (MPM) to date. The high-quality multiomics dataset and bioinformatics tools provided in this study will support the development of precision medicine in MPM.
Article
Oncology
Dean A. Fennell, Sean Ewings, Christian Ottensmeier, Raffaele Califano, Gerard G. Hanna, Kayleigh Hill, Sarah Danson, Nicola Steele, Mavis Nye, Lucy Johnson, Joanne Lord, Calley Middleton, Peter Szlosarek, Sam Chan, Aarti Gaba, Liz Darlison, Peter Wells-Jordan, Cathy Richards, Charlotte Poile, Jason F. Lester, Gareth Griffiths
Summary: The study evaluated the efficacy and safety of nivolumab in patients with pleural or peritoneal malignant mesothelioma who had progressed following platinum-based chemotherapy. Nivolumab showed improved progression-free survival and overall survival compared to placebo in these patients, with manageable treatment-related adverse events. The results suggest that nivolumab might be a beneficial treatment for patients with malignant mesothelioma who have progressed on first-line therapy.
Article
Biochemistry & Molecular Biology
Daniel L. Pouliquen, Marine Malloci, Alice Boissard, Cecile Henry, Catherine Guette
Summary: Curcumin's effects on tumor microenvironment and cancer cell invasiveness were investigated in a rat model of peritoneal mesothelioma. The study found that curcumin can modulate protein abundance and affect proteins related to tumor microenvironment regulation and activated T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Cai-Pu Chun, Lin-Xie Song, Hong-Pan Zhang, Dan -Dan Guo, Gui-Xuan Xu, Ya Li, Xin Xin, Jiachen Cao, Feng Li
Summary: This article presents a rare case of malignant peritoneal mesothelioma (MPM) in a 67-year-old male patient, with severe abdominal pain, bloating, and bloody ascites. The diagnosis was confirmed through cytology and laparoscopic exploratory biopsy. The characteristics of signs and clinical manifestations in this case are less common.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Antonia Marazioti, Anthi C. Krontira, Sabine J. Behrend, Georgia A. Giotopoulou, Giannoula Ntaliarda, Christophe Blanquart, Hasan Bayram, Marianthi Iliopoulou, Malamati Vreka, Lilith Trassl, Mario A. A. Pepe, Caroline M. Hackl, Laura Klotz, Stefanie A. Weiss, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Darcy E. Wagner, Helen Papadaki, Sophia G. Antimisiaris, Didier Jean, Sophie Deshayes, Marc Gregoire, Ozgecan Kayalar, Deniz Mortazavi, Sukru Dilege, Serhan Tanju, Suat Erus, Omer Yavuz, Pinar Bulutay, Pinar Firat, Ioannis Psallidas, Magda Spella, Ioanna Giopanou, Ioannis Lilis, Anne-Sophie Lamort, Georgios T. Stathopoulos
Summary: A portion of human MPM cases have mutations in KRAS, and mouse models suggest that KRAS mutations can lead to MPM, especially when combined with TP53 deletion. These findings indicate that KRAS alterations may play an important and underestimated role in certain MPM patients.
EMBO MOLECULAR MEDICINE
(2022)
Review
Oncology
Anne S. Tsao, Harvey Pass, Andreas Rimner, Aaron S. Mansfield
Summary: Malignant pleural mesothelioma (MPM) is a rare malignancy with limited treatment options. Recent advances have led to changes in treatment standards, including the use of a novel biomedical device in combination with platinum-pemetrexed and the inclusion of immunotherapy as a frontline treatment option. Proper identification of the MPM histology is crucial in determining the optimal treatment plan. Immunotherapy can benefit all MPM patients and should be considered at some point during treatment. Ongoing research is focusing on defining frontline therapy in the unresectable setting and addressing immunotherapy refractory cases.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Gaetano Pezzicoli, Mimma Rizzo, Martina Perrone, Silvia Minei, Luciano Mutti, Camillo Porta
Summary: Malignant mesothelioma (MMe) remains a challenging disease with limited therapeutic options, but recent introduction of Immune Checkpoint Inhibitors (ICIs) has shown some promising improvements. However, more efforts are still needed to improve the prognosis of MMe. Research focuses on novel antiangiogenic drugs, their combination with immunotherapy, and more complex strategies such as microRNA-loaded vectors, oncolytic viruses, and engineered lymphocytes.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Cita Zupanc, Alenka Franko, Danijela Strbac, Metoda Dodic Fikfak, Viljem Kovac, Vita Dolzan, Katja Goricar
Summary: The study evaluated serum calretinin as a potential biomarker in asbestos-related diseases, particularly in predicting malignant mesothelioma with high accuracy. Combining calretinin and SMRP showed the highest predictive value in distinguishing MM from other asbestos-related diseases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Rita Terenziani, Silvia Zoppi, Claudia Fumarola, Roberta Alfieri, Mara Bonelli
Summary: ICIs have emerged as a promising therapeutic option for difficult-to-treat cancers, especially showing superior efficacy in first-line treatment. Immunotherapeutic approaches for malignant pleural mesothelioma have also shown encouraging results. These novel treatments are crucial for the management of this disease.
Review
Medicine, General & Internal
Alejandro Gugliucci
Summary: In the past 50 years, the availability of sugar has greatly increased due to improved industrial processes and corn subsidies, particularly in the form of sweetened beverages. This has led to a higher prevalence of cardiometabolic disorders. Recent research highlights the crucial role of fructose in the development of dyslipidemia, specifically the increased synthesis and decreased catabolism of triglyceride-rich lipoproteins. The interaction between glucose and fructose in the liver promotes de novo lipogenesis and VLDL production, as well as inhibits the breakdown of lipoproteins, leading to the accumulation of atherogenic remnants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
DeVon Hunter-Schlichting, Karl T. Kelsey, Ryan Demmer, Manish Patel, Raphael Bueno, Brock Christensen, Naomi Fujioka, Deepa Kolarseri, Heather H. Nelson
Summary: A study found that nearly half of malignant pleural mesothelioma patients have high level current HCMV infection, with a higher detection rate of HCMV DNA in tumor tissue compared to normal pleural tissue, suggesting the pleura may serve as a reservoir for latent HCMV infection.