Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms

Structural basis for strand-transfer inhibitor binding to HIV intasomes

(2020) Dario Oliveira Passos et al.   SCIENCE

Structural basis of second-generation HIV integrase inhibitor action and viral resistance

(2020) Nicola J. Cook et al.   SCIENCE

Antiviral activity of HIV‐1 integrase strand‐transfer inhibitors against mutants with integrase resistance‐associated mutations and their frequency in treatment‐naïve individuals

(2019) Nicolas A. Margot et al.   JOURNAL OF MEDICAL VIROLOGY

Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition

(2019) Alan N. Engelman   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 integrase inhibitors that are broadly effective against drug-resistant mutants

(2018) Steven J. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current and emerging two-drug approaches for HIV-1 therapy in ART-naïve and ART-experienced, virologically suppressed patients

(2018) Barbara Rossetti et al.   EXPERT OPINION ON PHARMACOTHERAPY

Pathway involving the N155H mutation in HIV-1 integrase leads to dolutegravir resistance

(2018) Isabelle Malet et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Accumulation of multiple mutations in vivo confers cross-resistance to new and existing integrase inhibitors

(2018) Wendy W Zhang et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

(2018) Steven J. Smith et al.   Retrovirology

2018 IAS-USA Recommendations for the Use of Antiretroviral Therapy for HIV

(2018) James Riddell   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

(2017) Xue Zhi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM structures and atomic model of the HIV-1 strand transfer complex intasome

(2017) Dario Oliveira Passos et al.   SCIENCE

A supramolecular assembly mediates lentiviral DNA integration

(2017) Allison Ballandras-Colas et al.   SCIENCE

HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases

(2016) Xue Zhi Zhao et al.   ACS Chemical Biology

Effect of dolutegravir functional monotherapy on HIV-1 virological response in integrase strand transfer inhibitor resistant patients

(2016) Lisa K Naeger et al.   ANTIVIRAL THERAPY

Retroviral DNA Integration

(2016) Paul Lesbats et al.   CHEMICAL REVIEWS

Crystal structure of the Rous sarcoma virus intasome

(2016) Zhiqi Yin et al.   NATURE

Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function

(2016) Allison Ballandras-Colas et al.   NATURE

Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors

(2015) Izzat T. Raheem et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV Pathogenesis: Dynamics and Genetics of Viral Populations and Infected Cells

(2013) J. Coffin et al.   Cold Spring Harbor Perspectives in Medicine

3′-Processing and strand transfer catalysed by retroviral integrasein crystallo

(2012) Stephen Hare et al.   EMBO JOURNAL

Differential Sensitivities of Retroviruses to Integrase Strand Transfer Inhibitors

(2011) Y. Koh et al.   JOURNAL OF VIROLOGY

In VitroAntiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor

(2010) Masanori Kobayashi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Retroviral intasome assembly and inhibition of DNA strand transfer

(2010) Stephen Hare et al.   NATURE

Structure-based modeling of the functional HIV-1 intasome and its inhibition

(2010) L. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance

(2010) S. Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy

(2009) Damian J. McColl et al.   ANTIVIRAL RESEARCH

The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation

(2009) O. Delelis et al.   NUCLEIC ACIDS RESEARCH

Subgroup and Resistance Analyses of Raltegravir for Resistant HIV-1 Infection

(2008) David A. Cooper et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional and structural characterization of the integrase from the prototype foamy virus

(2008) Eugene Valkov et al.   NUCLEIC ACIDS RESEARCH