Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study

(2019) Madeleine K D Scott et al.   Lancet Respiratory Medicine

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Clinical Effectiveness of Antifibrotic Medications for Idiopathic Pulmonary Fibrosis

(2019) Timothy M. Dempsey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies

(2019) Stefanie R. Mullins et al.   Journal for ImmunoTherapy of Cancer

The therapy of idiopathic pulmonary fibrosis: what is next?

(2019) Vivien Somogyi et al.   European Respiratory Review

Differences in TLR7/8 activation between monocytes and macrophages

(2018) Hock-Liew Eng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication

(2018) Pardis Pakshir et al.   MATRIX BIOLOGY

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Evaluation of Novel Tumor-Targeted Near-Infrared Probe for Fluorescence-Guided Surgery of Cancer

(2018) Sakkarapalayam M. Mahalingam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Looking ahead and behind at supplemental oxygen: A qualitative study of patients with pulmonary fibrosis

(2017) Bridget A. Graney et al.   HEART & LUNG

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

(2017) Leah Cushing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

(2017) Alexander V. Misharin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

(2017) Carlene Petes et al.   Frontiers in Immunology

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Monocyte and macrophage contributions to cardiac remodeling

(2016) Maarten Hulsmans et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Strategies to overcome the hurdles to treat fibrosis, a major unmet clinical need

(2016) Jagdeep Nanchahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

(2016) Adam J. Byrne et al.   TRENDS IN MOLECULAR MEDICINE

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs

(2015) Hartmut Grasemann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Pulmonary macrophages: key players in the innate defence of the airways

(2015) Adam J Byrne et al.   THORAX

Macrophages During the Fibrotic Process: M2 as Friend and Foe

(2015) Tarcio Teodoro Braga et al.   Frontiers in Immunology

Folate Receptor-β in Activated Macrophages: Ligand Binding and Receptor Recycling Kinetics

(2014) Bindu Varghese et al.   MOLECULAR PHARMACEUTICS

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages

(2014) Maria Ruweka Fernando et al.   PLoS One

Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage

(2013) Thian Kui Tan et al.   LABORATORY INVESTIGATION

Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

(2013) Yoony YJ Gent et al.   ARTHRITIS RESEARCH & THERAPY

Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity

(2011) M Biffen et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

(2011) Yang Feng et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like receptor-7 agonist administered subcutaneously in a prolonged dosing schedule in heavily pretreated recurrent breast, ovarian, and cervix cancers

(2010) Melissa A. Geller et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Effect of an immunotoxin to folate receptor β on bleomycin-induced experimental pulmonary fibrosis

(2010) T. Nagai et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

(2010) Mark S. Wilson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Low-dose oral interferon   possibly retards the progression of idiopathic pulmonary fibrosis and alleviates associated cough in some patients

(2010) L. O. Lutherer et al.   THORAX

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH