Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1

Epithelial Migration and Non-adhesive Periderm Are Required for Digit Separation during Mammalian Development

(2020) Ghaidaa Kashgari et al.   DEVELOPMENTAL CELL

The molecular anatomy of mammalian upper lip and primary palate fusion at single cell resolution

(2019) Hong Li et al.   DEVELOPMENT

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

Closing the Gap: Mouse Models to Study Adhesion in Secondary Palatogenesis

(2017) K.J. Lough et al.   JOURNAL OF DENTAL RESEARCH

Periderm: Life-cycle and function during orofacial and epidermal development

(2017) Nigel L. Hammond et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate

(2017) Rose Richardson et al.   PLoS Genetics

Shared molecular networks in orofacial and neural tube development

(2017) Youssef A. Kousa et al.   Birth Defects Research

LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development

(2016) Kevin M. Byrd et al.   DEVELOPMENT

Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium

(2016) Sayaka Katsunuma et al.   JOURNAL OF CELL BIOLOGY

p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis

(2015) Maria Rosaria Mollo et al.   EXPERIMENTAL DERMATOLOGY

Novel homozygous mutation, c.400C>T (p.Arg134*), in thePVRL1gene underlies cleft lip/palate-ectodermal dysplasia syndrome in an Asian patient

(2015) Kazue Yoshida et al.   JOURNAL OF DERMATOLOGY

Convergence and Extrusion Are Required for Normal Fusion of the Mammalian Secondary Palate

(2015) Seungil Kim et al.   PLOS BIOLOGY

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

Periderm cells covering palatal shelves have tight junctions and their desquamation reduces the polarity of palatal shelf epithelial cells in palatogenesis

(2012) Midori Yoshida et al.   GENES TO CELLS

Afadin, A Ras/Rap Effector That Controls Cadherin Function, Promotes Spine and Excitatory Synapse Density in the Hippocampus

(2012) G. M. J. Beaudoin et al.   JOURNAL OF NEUROSCIENCE

Intra-amniotic Transient Transduction of the Periderm With a Viral Vector Encoding TGFβ3 Prevents Cleft Palate in Tgfβ3−/− Mouse Embryos

(2012) Chadwick Wu et al.   MOLECULAR THERAPY

Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development

(2011) J. O. Bush et al.   DEVELOPMENT

Cleft lip and palate: understanding genetic and environmental influences

(2011) Michael J. Dixon et al.   NATURE REVIEWS GENETICS

Nectins Establish a Checkerboard-Like Cellular Pattern in the Auditory Epithelium

(2011) H. Togashi et al.   SCIENCE

Mutations in PVRL4, Encoding Cell Adhesion Molecule Nectin-4, Cause Ectodermal Dysplasia-Syndactyly Syndrome

(2010) Francesco Brancati et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth

(2010) Toshiyuki Yoshida et al.   DEVELOPMENTAL DYNAMICS

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence

(2009) Rebecca J. Richardson et al.   HUMAN MOLECULAR GENETICS

Cleft lip and palate

(2009) Peter A Mossey et al.   LANCET

The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice

(2008) Martin J. Barron et al.   HUMAN MOLECULAR GENETICS