Review
Cell Biology
Yuting Ma, Yongping Liu, Fang Han, Hongyan Qiu, Junfeng Shi, Na Huang, Ningning Hou, Xiaodong Sun
Summary: GDF11 is a critical rejuvenation factor that may improve outcomes in neurodegenerative and neurovascular diseases, as well as muscle health. There is controversy regarding its functional roles, but it shows potential for reversing age-related pathological changes and regulating organ regeneration.
Article
Geriatrics & Gerontology
Liming Peng, Thiago Gagliano-Juca, Karol M. Pencina, Srinivasan Krishnan, Zhuoying Li, Russell P. Tracy, Ravi Jasuja, Shalender Bhasin
Summary: A LC-MS/MS method for measuring circulating GDF-8 and GDF-11 was developed. The levels of GDF-8 and GDF-11 were not related to age or body composition in healthy men. Testosterone treatment increased GDF-8 levels, but not GDF-11 levels.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Shehla Pervin, Srinivasa T. Reddy, Rajan Singh
Summary: Obesity is a global health issue associated with metabolic disorders. Activation of the TGF-beta signaling pathway contributes to the development of obesity, while blockade or inhibition has the potential to protect against obesity by promoting fat browning and increasing mitochondrial biogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Carmella C. Nugent Britt, Leilani X. Alvarez, Kenneth Lamb
Summary: The study found that a single dose of 6 or 12 g of Fortetropin did not decrease serum myostatin levels in healthy adult dogs over a 72-hour period. Further research is needed to determine the efficacy and bioavailability of oral supplements like Fortetropin for clinical use in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Rong Huang, Mark Kibschull, Laurent Briollais, Zdenka Pausova, Kellie Murphy, John Kingdom, Stephen Lye, Zhong-Cheng Luo
Summary: The study found that fetal sex affects the concentration of myostatin in cord blood, with higher levels in male fetuses. Gestational diabetes does not affect the concentration of myostatin in cord blood. The study also revealed a strong correlation between myostatin and testosterone levels in male fetuses.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Ming Y. Lim, Mouhamed Yazan Abou-Ismail, D. Ware Branch
Summary: The most common thrombotic microangiopathy (TMA) of pregnancy is preeclampsia with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. Rare TMAs, such as thrombotic thrombocytopenic purpura, complement-mediated hemolytic-uremic syndrome, and catastrophic antiphospholipid syndrome, may also occur during pregnancy or postpartum with symptoms similar to severe preeclampsia. Early recognition and treatment are crucial to avoid serious complications.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Geriatrics & Gerontology
Yuko Yamaguchi, Min Zhu, Ruin Moaddel, Elango Palchamy, Luigi Ferrucci, Richard D. Semba
Summary: This study aimed to investigate the relationship between plasma concentrations of GDF8, GDF11, FST, WFIKKN1, and WFIKKN2 and the decline of grip strength in older adults. The results showed that circulating GDF8, GDF11, and their antagonists do not appear to influence the decline of grip strength in older men or women.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Veterinary Sciences
Xin-Yue Liu, Hak Myong Choe, Zhou-Yan Li, Zheng-Yun Jin, Shuang-Yan Chang, Jin-Dan Kang, Xi -jun Yin, Biao-Hu Quan
Summary: This study found that knockout of myostatin (MSTN) can increase the smooth muscle content of uterine horns, providing potential therapeutic targets for pregnancy disorders caused by increased smooth muscle content.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Geriatrics & Gerontology
Yang Zhou, Shousheng Ni, Congjun Li, Lili Song, Shicui Zhang
Summary: This study confirms the bioavailability of oral delivery of recombinant GDF11 in mice and suggests its potential role in restoring ovarian and testicular functions and fertility. Furthermore, GDF11 slows down the aging process of these reproductive organs by enhancing the activities of antioxidant enzymes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Hirofumi Nagao, Weikang Cai, Bruna B. Brandao, Nicolai J. Wewer Albrechtsen, Martin Steger, Arijeet K. Gattu, Hui Pan, Jonathan M. Dreyfuss, F. Thomas Wunderlich, Matthias Mann, C. Ronald Kahn
Summary: Insulin and IGF-1 receptors have similar signaling systems but different physiological roles. Replacement of leucine-973 in the intracellular juxtamembrane region with phenylalanine resulted in altered signaling, decreased insulin sensitivity, increased cell growth, and impaired receptor internalization. This amino acid residue plays a crucial role in differentiating the signaling of IR and IGF1R.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Bridget Vermeulen, Lebo F. Gafane-Matemane, Aletta E. Schutte, Ruan Kruger
Summary: The study aimed to investigate the relationship between GDF-15 levels and various indicators such as body weight, waist circumference, BMI, and leptin in young adults. The results showed that in the overweight/obese group, these indicators were positively associated with GDF-15, while in the underweight group they were negatively associated with GDF-15.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Geriatrics & Gerontology
Zoico Elena, Saatchi Tanaz, Nori Nicole, Mazzali Gloria, Rizzatti Vanni, Pizzi Eleonora, Fantin Francesco, Giani Anna, Urbani Silvia, Zamboni Mauro
Summary: Recently, studies have shown that dysfunction of white adipose tissue (WAT) has a negative impact on skeletal muscle function and quality. However, little is known about the effects of senescent adipocytes on muscle cells. In this in vitro experiment, we found that conditioned medium obtained from cultures of aged or stressed adipocytes can significantly decrease the diameter and fusion index of myotubes, reduce gene expression of myogenic differentiation markers, increase genes involved in muscle atrophy, and inhibit protein synthesis in muscle cells. These preliminary results suggest that aged adipocytes may negatively affect the trophism, function, and regenerative capacity of myocytes through paracrine signaling.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Endocrinology & Metabolism
Dong An, Bryan Tan, Dao-Yi Yu, Chandrakumar Balaratnasingam
Summary: Microaneurysms are influenced by capillary nonperfusion, pericyte loss, and inflammation in diabetic retinopathy. These factors were found to be independent predictors of microaneurysm size. Nonperfusion alone without pericyte loss or inflammation was not a significant predictor of microaneurysm leakage.
Article
Agriculture, Dairy & Animal Science
Asad Ali, Khalid Javed, Imran Zahoor, Khalid Mahmood Anjum, Numan Sharif
Summary: This study identified multiple SNPs in the MSTN and ADRB3 genes that were associated with growth and carcass traits in Kajli sheep. These SNPs can serve as genetic markers for selecting sheep breeds with desirable meat quality.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lingfang Zhuang, Kangni Jia, Chen Chen, Zhigang Li, Jiaxin Zhao, Jian Hu, Hang Zhang, Qin Fan, Chunkai Huang, Hongyang Xie, Lin Lu, Weifeng Shen, Guang Ning, Jiqiu Wang, Ruiyan Zhang, Kang Chen, Xiaoxiang Yan
Summary: This study reveals the significant role of DYRK1B in mitochondrial bioenergetics and the progression of cardiac hypertrophy and heart failure. DYRK1B promotes impaired mitochondrial bioenergetics by directly binding with STAT3, leading to the downregulation of PGC-1 alpha. Inhibition of DYRK1B or STAT3 activity restores cardiac performance by rejuvenating mitochondrial bioenergetics. These findings may offer new therapeutic options for heart failure patients.
Article
Cell Biology
Qiyuan Yang, Xingwei Liang, Xiaofei Sun, Lupei Zhang, Xing Fu, Carl J. Rogers, Anna Berim, Shuming Zhang, Songbo Wang, Bo Wang, Marc Foretz, Benoit Viollet, David R. Gang, Buel D. Rodgers, Mei-Jun Zhu, Min Du
Article
Endocrinology & Metabolism
Naisi Li, Qiyuan Yang, Ryan G. Walker, Thomas B. Thompson, Min Du, Buel D. Rodgers
Article
Cell Biology
Catherine E. Winbanks, Kate T. Murphy, Bianca C. Bernardo, Hongwei Qian, Yingying Liu, Patricio V. Sepulveda, Claudia Beyer, Adam Hagg, Rachel E. Thomson, Justin L. Chen, Kelly L. Walton, Kate L. Loveland, Julie R. McMullen, Buel D. Rodgers, Craig A. Harrison, Gordon S. Lynch, Paul Gregorevic
SCIENCE TRANSLATIONAL MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Bo Wang, Zhixiu Wang, Jeanene M. de Avila, Mei-Jun Zhu, Faya Zhang, Noe Alberto Gomez, Liang Zhao, Qiyu Tian, Junxing Zhao, Joseph Maricelli, Hui Zhang, Buel D. Rodgers, Min Du
Article
Physiology
Jordan D. Rehwaldt, Buel D. Rodgers, David C. Lin
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Physiology
Joseph W. Maricelli, Denali R. Kagel, Yemeserach M. Bishaw, O. Lynne Nelson, David C. Lin, Buel D. Rodgers
JOURNAL OF APPLIED PHYSIOLOGY
(2017)
Article
Food Science & Technology
Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Article
Medicine, General & Internal
Bo Wang, Xing Fu, Xingwei Liang, Zhixiu Wang, Qiyuan Yang, Tiande Zou, Wei Nie, Junxing Zhao, Pengfei Gao, Mei-Jun Zhu, Jeanene M. de Avila, Joseph Maricelli, Buel D. Rodgers, Min Du
Article
Biotechnology & Applied Microbiology
Joseph W. Maricelli, Yemeserach M. Bishaw, Bo Wang, Min Du, Buel D. Rodgers
HUMAN GENE THERAPY
(2018)
Article
Endocrinology & Metabolism
Wioletta Czaja, Yukiko K. Nakamura, Naisi Li, Jennifer A. Eldridge, David M. DeAvila, Thomas B. Thompson, Buel D. Rodgers
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Article
Cell Biology
Axel J. Fenwick, Peter O. Awinda, Jacob A. Yarbrough-Jones, Jennifer A. Eldridge, Buel D. Rodgers, Bertrand C. W. Tanner
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Medicine, Research & Experimental
Buel D. Rodgers, Yemeserach Bishaw, Denali Kagel, Julian N. Ramos, Joseph W. Maricelli
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2020)
Review
Endocrinology & Metabolism
Buel D. Rodgers, Christopher W. Ward
Summary: Muscle wasting diseases are debilitating and often deadly, with current treatment strategies relatively ineffective. Promising treatments in development target disrupting myostatin and activin receptor signaling, as well as involve antibodies and gene therapeutics. Success in these developments could revolutionize the treatment of muscle wasting conditions.
Article
Medicine, Research & Experimental
Buel D. Rodgers, Sarah K. Herring, Dereck R. Carias, Joyce Chen, Agostinho G. Rocha
Summary: A fit-for-purpose model process was developed to validate a GLP-compliant ddPCR assay for AVGN7 gene therapy. The method demonstrated high precision, accuracy, and sensitivity, exceeding established standards in the field.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2023)