标题
Novel Murine Models of Cerebral Cavernous Malformations
作者
关键词
-
出版物
ANGIOGENESIS
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-07-25
DOI
10.1007/s10456-020-09736-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Novel Chronic Mouse Model of Cerebral Cavernous Malformations
- (2020) Cécile Cardoso et al. STROKE
- Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature
- (2020) Janne Koskimäki et al. World Neurosurgery
- Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease
- (2019) Robert Shenkar et al. STROKE
- A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease
- (2019) Lisa McKerracher et al. Translational Stroke Research
- VEGF signalling enhances lesion burden in KRIT1 deficient mice
- (2019) Peter V. DiStefano et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Phenotypic characterization of murine models of cerebral cavernous malformations
- (2018) Hussein A. Zeineddine et al. LABORATORY INVESTIGATION
- Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
- (2018) Cécile Otten et al. EMBO Molecular Medicine
- Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
- (2018) Miguel Alejandro Lopez-Ramirez et al. BLOOD
- Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations
- (2018) Jaesung P. Choi et al. Science Advances
- Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations
- (2017) Miguel Alejandro Lopez-Ramirez et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Endothelial TLR4 and the microbiome drive cerebral cavernous malformations
- (2017) Alan T. Tang et al. NATURE
- Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
- (2017) Sayoko Nishimura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations
- (2017) Romuald Girard et al. Translational Stroke Research
- B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models
- (2016) Changbin Shi et al. Journal of Neuroimmune Pharmacology
- Propranolol stops progressive multiple cerebral cavernoma in an adult patient
- (2016) Matthias Reinhard et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data
- (2016) Margaret A Horne et al. LANCET NEUROLOGY
- Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling
- (2016) Zinan Zhou et al. NATURE
- Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation
- (2016) Huanjiao Jenny Zhou et al. NATURE MEDICINE
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
- (2016) Robert Shenkar et al. STROKE
- Propranolol Treatment of Cavernous Malformations with Symptomatic Hemorrhage
- (2016) Joseph M. Zabramski et al. World Neurosurgery
- Defective autophagy is a key feature of cerebral cavernous malformations
- (2015) Saverio Marchi et al. EMBO Molecular Medicine
- KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
- (2015) R. Cuttano et al. EMBO Molecular Medicine
- Sulindac metabolites decrease cerebrovascular malformations inCCM3-knockout mice
- (2015) Luca Bravi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling
- (2015) Benjamin Lant et al. Nature Communications
- Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations
- (2014) Robert Shenkar et al. GENETICS IN MEDICINE
- Lack of CCM1 induces hypersprouting and impairs response to flow
- (2014) Tara M. Mleynek et al. HUMAN MOLECULAR GENETICS
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis
- (2014) David A. McDonald et al. HUMAN MOLECULAR GENETICS
- CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling
- (2013) Eva Faurobert et al. JOURNAL OF CELL BIOLOGY
- EndMT contributes to the onset and progression of cerebral cavernous malformations
- (2013) Luigi Maddaluno et al. NATURE
- Dynamic Regulation of the Cerebral Cavernous Malformation Pathway Controls Vascular Stability and Growth
- (2012) Xiangjian Zheng et al. DEVELOPMENTAL CELL
- Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study
- (2012) Rustam Al-Shahi Salman et al. LANCET NEUROLOGY
- Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease
- (2011) Bilge Yoruk et al. DEVELOPMENTAL BIOLOGY
- Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice
- (2011) Aubrey C. Chan et al. JOURNAL OF CLINICAL INVESTIGATION
- Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice
- (2011) Gwénola Boulday et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TAK1 in brain endothelial cells mediates fever and lethargy
- (2011) Dirk A. Ridder et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Loss ofcerebral cavernous malformation 3(Ccm3) in neuroglia leads to CCM and vascular pathology
- (2011) Angeliki Louvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease
- (2011) David A. McDonald et al. STROKE
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease
- (2010) D. A. McDonald et al. HUMAN MOLECULAR GENETICS
- Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype
- (2010) Asya L. Borikova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
- (2010) Rebecca A. Stockton et al. JOURNAL OF EXPERIMENTAL MEDICINE
- KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species
- (2010) Luca Goitre et al. PLoS One
- Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling
- (2010) Joycelyn Wüstehube et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stabilization of VEGFR2 Signaling by Cerebral Cavernous Malformation 3 Is Critical for Vascular Development
- (2010) Y. He et al. Science Signaling
- Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations
- (2009) G. Boulday et al. Disease Models & Mechanisms
- Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein
- (2009) Katrin Voss et al. HUMAN MUTATION
- Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells
- (2009) Lisa E. S. Crose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
- (2009) Kevin J Whitehead et al. NATURE MEDICINE
- Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway
- (2009) Benjamin Kleaveland et al. NATURE MEDICINE
- CEREBRAL CAVERNOUS MALFORMATIONS
- (2009) Judith Gault et al. NEUROSURGERY
- Immune Response in Human Cerebral Cavernous Malformations
- (2009) Changbin Shi et al. STROKE
- Efficient, inducible Cre-recombinase activation in vascular endothelium
- (2008) Suzanne Claxton et al. GENESIS
- ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafish
- (2008) Benjamin M. Hogan et al. HUMAN MOLECULAR GENETICS
- Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis
- (2008) Amy L. Akers et al. HUMAN MOLECULAR GENETICS
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started