A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease
出版年份 2019 全文链接
标题
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease
作者
关键词
Vascular permeability, Rho kinase, Cerebral cavernous malformation, Hemangioma, Therapeutics
出版物
Translational Stroke Research
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-08-25
DOI
10.1007/s12975-019-00725-8
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease
- (2019) Robert Shenkar et al. STROKE
- Cerebral Cavernous Malformation 1/2 complex controls ROCK1 and ROCK2 complementary functions for endothelial integrity
- (2018) Justyna Lisowska et al. JOURNAL OF CELL SCIENCE
- Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
- (2018) Sean P Polster et al. NEUROSURGERY
- Rho kinase inhibitors: a patent review (2014 – 2016)
- (2017) Olivier Defert et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models
- (2016) Changbin Shi et al. Journal of Neuroimmune Pharmacology
- Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease
- (2016) Romuald Girard et al. JOURNAL OF NEUROSCIENCE METHODS
- Clinical course of untreated cerebral cavernous malformations: a meta-analysis of individual patient data
- (2016) Margaret A Horne et al. LANCET NEUROLOGY
- RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations
- (2016) Robert Shenkar et al. STROKE
- FSD-C10: A more promising novel ROCK inhibitor than Fasudil for treatment of CNS autoimmunity
- (2015) Y.-L. Xin et al. BIOSCIENCE REPORTS
- ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity
- (2015) Karen A. Newell-Litwa et al. JOURNAL OF CELL BIOLOGY
- Vascular Permeability in Cerebral Cavernous Malformations
- (2015) Abdul G Mikati et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors
- (2015) Jeremy Green et al. JOURNAL OF MEDICINAL CHEMISTRY
- ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension
- (2015) Cora M.L. Beckers et al. VASCULAR PHARMACOLOGY
- The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease
- (2015) Svenja Hartmann et al. Frontiers in Pharmacology
- Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations
- (2014) Robert Shenkar et al. GENETICS IN MEDICINE
- Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis
- (2014) David A. McDonald et al. HUMAN MOLECULAR GENETICS
- A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology
- (2014) Shahram Eisa-Beygi et al. STROKE
- Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis
- (2013) Andreas Fischer et al. TRENDS IN MOLECULAR MEDICINE
- Natural history and imaging prevalence of cavernous malformations in children and young adults
- (2012) Wajd N. Al-Holou et al. Journal of Neurosurgery-Pediatrics
- Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study
- (2012) Rustam Al-Shahi Salman et al. LANCET NEUROLOGY
- Role of Rho kinase isoforms in murine allergic airway responses
- (2011) M. Zhu et al. EUROPEAN RESPIRATORY JOURNAL
- In Vitro Characterization of the Angiogenic Phenotype and Genotype of the Endothelia Derived From Sporadic Cerebral Cavernous Malformations
- (2011) Yuan Zhu et al. NEUROSURGERY
- Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease
- (2011) David A. McDonald et al. STROKE
- Recent insights into cerebral cavernous malformations: the molecular genetics of CCM
- (2010) Florence Riant et al. FEBS Journal
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease
- (2010) D. A. McDonald et al. HUMAN MOLECULAR GENETICS
- Rho Kinase Inhibition Rescues the Endothelial Cell Cerebral Cavernous Malformation Phenotype
- (2010) Asya L. Borikova et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity
- (2010) Rebecca A. Stockton et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Rho Signaling and Tight Junction Functions
- (2010) Steve Terry et al. PHYSIOLOGY
- ROCK Isoform Regulation of Myosin Phosphatase and Contractility in Vascular Smooth Muscle Cells
- (2009) Yuepeng Wang et al. CIRCULATION RESEARCH
- The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases
- (2009) Kevin J Whitehead et al. NATURE MEDICINE
- Biology of Vascular Malformations of the Brain
- (2009) Gabrielle G. Leblanc et al. STROKE
- Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis
- (2008) Amy L. Akers et al. HUMAN MOLECULAR GENETICS
- Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP
- (2008) Kazutaka Mori et al. JOURNAL OF BIOLOGICAL CHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now