Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease

Fasudil combined with methylcobalamin or lipoic acid can improve the nerve conduction velocity in patients with diabetic peripheral neuropathy

(2018) De-Qi Jiang et al.   MEDICINE

Combined statin and angiotensin-converting enzyme (ACE) inhibitor treatment increases the lifespan of long-lived F1 male mice

(2016) Stephen R. Spindler et al.   AGE

B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models

(2016) Changbin Shi et al.   Journal of Neuroimmune Pharmacology

Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease

(2016) Romuald Girard et al.   JOURNAL OF NEUROSCIENCE METHODS

Simvastatin and cerebral cavernous malformations (Re: Reinhard et al., 2016)

(2016) Shahram Eisa-Beygi   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

(2016) Zinan Zhou et al.   NATURE

Pleiotropic effects of statins: new therapeutic targets in drug design

(2016) Onkar Bedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations

(2016) Robert Shenkar et al.   STROKE

Sulindac metabolites decrease cerebrovascular malformations inCCM3-knockout mice

(2015) Luca Bravi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for the Management of Spontaneous Intracerebral Hemorrhage

(2015) J. Claude Hemphill et al.   STROKE

Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations

(2014) Robert Shenkar et al.   GENETICS IN MEDICINE

KRIT1 Protein Depletion Modifies Endothelial Cell Behavior via Increased Vascular Endothelial Growth Factor (VEGF) Signaling

(2014) Peter V. DiStefano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Call for Rigorous Study of Statins in Resolution of Cerebral Cavernous Malformation Pathology

(2014) Shahram Eisa-Beygi et al.   STROKE

Loss of CCM3 impairs DLL4-Notch signalling: implication in endothelial angiogenesis and in inherited cerebral cavernous malformations

(2013) Chao You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway

(2012) Shahram Eisa-Beygi et al.   DEVELOPMENTAL BIOLOGY

Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

(2012) Rustam Al-Shahi Salman et al.   LANCET NEUROLOGY

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Statin Use and Microbleeds in Patients With Spontaneous Intracerebral Hemorrhage

(2012) Diogo C. Haussen et al.   STROKE

Statins accelerate the onset of collagen type II-induced arthritis in mice

(2012) Rob J Vandebriel et al.   ARTHRITIS RESEARCH & THERAPY

What is a relevant statin concentration in cell experiments claiming pleiotropic effects?

(2011) Linda Björkhem-Bergman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Statin use and outcome after intracerebral hemorrhage: Case-control study and meta-analysis

(2011) A. Biffi et al.   NEUROLOGY

Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event

(2011) Masahiro Ishihara et al.   NEURORADIOLOGY

Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease

(2011) David A. McDonald et al.   STROKE

Pleiotropic Effects of Statins

(2010) Qian Zhou et al.   CIRCULATION JOURNAL

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

(2010) D. A. McDonald et al.   HUMAN MOLECULAR GENETICS

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

(2010) Joycelyn Wüstehube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention

(2009) Pierre Amarenco et al.   LANCET NEUROLOGY

Comparison of Effects of Rosuvastatin (10 mg) Versus Atorvastatin (40 mg) on Rho Kinase Activity in Caucasian Men With a Previous Atherosclerotic Event

(2008) Ron Rawlings et al.   AMERICAN JOURNAL OF CARDIOLOGY

Statins inhibit Rho kinase activity in patients with atherosclerosis

(2008) Anju Nohria et al.   ATHEROSCLEROSIS

A PP2A Phosphatase High Density Interaction Network Identifies a Novel Striatin-interacting Phosphatase and Kinase Complex Linked to the Cerebral Cavernous Malformation 3 (CCM3) Protein

(2008) Marilyn Goudreault et al.   MOLECULAR & CELLULAR PROTEOMICS

Hemorrhage From Cavernous Malformations of the Brain

(2008) Rustam Al-Shahi Salman et al.   STROKE