Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

(2019) Yujie Huang et al.   Aging-US

Antiatherogenic Effect of Resveratrol Attributed to Decreased Expression of ICAM-1 (Intercellular Adhesion Molecule-1)

(2019) Youngsik Seo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Blood Pressure–Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase

(2019) Oleksandra Prysyazhna et al.   CIRCULATION

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

(2019) Gabriel M. Brawerman et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resveratrol attenuates endothelial oxidative injury by inducing autophagy via the activation of transcription factor EB

(2019) Xi Zhou et al.   Nutrition & Metabolism

The potential therapeutic benefit of resveratrol on Th17/Treg imbalance in immune thrombocytopenic purpura

(2019) Ning-Hong Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Statistical analysis of human microarray data shows that dietary intervention with n-3 fatty acids, flavonoids and resveratrol enriches for immune response and disease pathways

(2018) Alix Warburton et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol Alleviates Inflammatory Responses and Oxidative Stress in Rat Kidney Ischemia-Reperfusion Injury and H2O2-Induced NRK-52E Cells via the Nrf2/TLR4/NF-κB Pathway

(2018) Jiawei Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effects of resveratrol supplementation on liver fat content in overweight and insulin-resistant subjects: A randomized, double-blind, placebo-controlled clinical trial

(2018) Konstantinos Kantartzis et al.   DIABETES OBESITY & METABOLISM

Resveratrol induces sumoylated COX-2-dependent anti-proliferation in human prostate cancer LNCaP cells

(2018) Tsai-Mu Cheng et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial

(2018) Somayyeh Asghari et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages

(2018) Nicole C. Smith et al.   MOLECULAR IMMUNOLOGY

Resveratrol Induces Brain Resilience Against Alzheimer Neurodegeneration Through Proteostasis Enhancement

(2018) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Effects of resveratrol on memory performance, hippocampus connectivity and microstructure in older adults – A randomized controlled trial

(2018) Sebastian Huhn et al.   NEUROIMAGE

Protective effects and immunomodulation on piglets infected with rotavirus following resveratrol supplementation

(2018) Qiankun Cui et al.   PLoS One

Resveratrol, an antioxidant, protects spinal cord injury in rats by suppressing MAPK pathway

(2018) Song Fu et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Dietary resveratrol improves antioxidant status of sows and piglets and regulates antioxidant gene expression in placenta by Keap1-Nrf2 pathway and Sirt1

(2018) Qingwei Meng et al.   Journal of Animal Science and Biotechnology

Proteomic approach to identify molecular signatures during experimental hepatic fibrosis and resveratrol supplementation

(2018) Areeba Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease

(2018) David Porquet et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of resveratrol on bone health in type 2 diabetic patients. A double-blind randomized-controlled trial

(2018) Simona Bo et al.   Nutrition & Diabetes

Resveratrol: Twenty Years of Growth, Development and Controversy

(2018) John M. Pezzuto   Biomolecules & Therapeutics

Are the cardioprotective effects of the phytoestrogen resveratrol sex dependent?

(2018) Xavier Lieben Louis et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation

(2018) Daniele Maria Lopes Pinheiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol significantly inhibits the occurrence and development of cervical cancer by regulating phospholipid scramblase 1

(2018) Yanhua Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Endothelial Cells Deconjugate Resveratrol Metabolites to Free Resveratrol: A Possible Role in Tissue Factor Modulation

(2018) Sara Fernández-Castillejo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol suppresses the invasion and migration of human gastric cancer cells via inhibition of MALAT1‑mediated epithelial‑to‑mesenchymal transition

(2018) Zhuying Yang et al.   Experimental and Therapeutic Medicine

Resveratrol alleviates inflammatory hyperalgesia by modulation of reactive oxygen species (ROS), antioxidant enzymes and ERK activation

(2017) Ajeet Kumar Singh et al.   INFLAMMATION RESEARCH

Serum concentrations and gene expression of sirtuin 1 in healthy and slightly overweight subjects after caloric restriction or resveratrol supplementation: A randomized trial

(2017) Antonio P. Mansur et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol Ameliorates Palmitate-Induced Inflammation in Skeletal Muscle Cells by Attenuating Oxidative Stress and JNK/NF-κB Pathway in a SIRT1-Independent Mechanism

(2017) Asie Sadeghi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol pretreatment enhanced homing of SDF-1α-preconditioned bone marrow-derived mesenchymal stem cells in a rat model of liver cirrhosis

(2017) Mehrdad Hajinejad et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Resveratrol supplementation of high-fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring

(2017) Tiande Zou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Resveratrol improves alcoholic fatty liver disease by downregulating HIF-1α expression and mitochondrial ROS production

(2017) Zhenhua Ma et al.   PLoS One

Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

(2017) Alexandra Wagnerova et al.   Gastroenterology Research and Practice

Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK/TGF-β1 pathway

(2017) Yuan Qiao et al.   Experimental and Therapeutic Medicine

Fruits for Prevention and Treatment of Cardiovascular Diseases

(2017) Cai-Ning Zhao et al.   Nutrients

Dietary Sources and Bioactivities of Melatonin

(2017) Xiao Meng et al.   Nutrients

Resveratrol Pretreatment Attenuates Concanavalin A-induced Hepatitis through Reverse of Aberration in the Immune Response and Regenerative Capacity in Aged Mice

(2017) Tse-Hung Huang et al.   Scientific Reports

Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade

(2017) Guangxi Wang et al.   Scientific Reports

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease

(2017) Mary M. McDermott et al.   JAMA Cardiology

Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae

(2017) Begoña Euba et al.   Scientific Reports

Resveratrol Ameliorates Alcoholic Fatty Liver by Inducing Autophagy

(2016) Liying Tang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Metformin and resveratrol ameliorate muscle insulin resistance through preventing lipolysis and inflammation in hypoxic adipose tissue

(2016) Wenjun Zhao et al.   CELLULAR SIGNALLING

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

(2016) Hanaa Hibishy Gaballah et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome

(2016) Miranda M. Sung et al.   DIABETES

Resveratrol exerts anti-obesity effects in high-fat diet obese mice and displays differential dosage effects on cytotoxicity, differentiation, and lipolysis in 3T3-L1 cells

(2016) Chih-Chun Chang et al.   ENDOCRINE JOURNAL

Resveratrol inhibits Hexokinases II mediated glycolysis in non-small cell lung cancer via targeting Akt signaling pathway

(2016) Wei Li et al.   EXPERIMENTAL CELL RESEARCH

Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis

(2016) Sathish Babu Vasamsetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

The enhancement of immune function and activation of NF-κB by resveratrol-treatment in immunosuppressive mice

(2016) Xin Lai et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Alterations of antioxidant status in asymptomatic hypercholesterolemic individuals after resveratrol intake

(2016) C. Apostolidou et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity

(2016) Maureen Jepkorir Cheserek et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

(2016) Xiangrong Cui et al.   Molecular Medicine Reports

Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in Diabetes Mellitus

(2016) Han Wu et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Interferes with IL1-β-Induced Pro-Inflammatory Paracrine Interaction between Primary Chondrocytes and Macrophages

(2016) Emeric Limagne et al.   Nutrients

Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short

(2016) Carla S. Andrews et al.   Scientific Reports

Anti-inflammatory effect of resveratrol through the suppression of NF- B and JAK/STAT signaling pathways

(2015) C. Ma et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study

(2015) Montserrat Rabassa et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a randomized controlled trial

(2015) Sony S Thazhath et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Resveratrol restored Nrf2 function, reduced renal inflammation, and mitigated hypertension in spontaneously hypertensive rats

(2015) Apurva A. Javkhedkar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia

(2015) Paola Mastromarino et al.   ANTIVIRAL RESEARCH

MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson’s disease mouse

(2015) Zhao-Hui Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Resveratrol reduces amyloid-beta (Aβ1–42)-induced paralysis through targeting proteostasis in an Alzheimer model of Caenorhabditis elegans

(2015) Charlotte Regitz et al.   EUROPEAN JOURNAL OF NUTRITION

Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation

(2015) Eric Chong et al.   HEART RHYTHM

Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment

(2015) Zu Yue Deng et al.   INFLAMMATION RESEARCH

Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome

(2015) Takuma Misawa et al.   INTERNATIONAL IMMUNOLOGY

Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters

(2015) Hasan Gencoglu et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Resveratrol and sildenafil synergistically improve diabetes-associated erectile dysfunction in streptozotocin-induced diabetic rats

(2015) Yufeng Bai et al.   LIFE SCIENCES

Resveratrol protects mice from paraquat-induced lung injury: The important role of SIRT1 and NRF2 antioxidant pathways

(2015) SHENGQIN LI et al.   Molecular Medicine Reports

Resveratrol increases CD68+Kupffer cells colocalized with adipose differentiation-related protein and ameliorates high-fat-diet-induced fatty liver in mice

(2015) Kahoko Nishikawa et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice

(2015) Hong Cai et al.   Science Translational Medicine

Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity

(2015) Yuhei Nishimura et al.   Frontiers in Pharmacology

Resveratrol Inhibits Enterovirus 71 Replication and Pro-Inflammatory Cytokine Secretion in Rhabdosarcoma Cells through Blocking IKKs/NF-κB Signaling Pathway

(2015) Li Zhang et al.   PLoS One

Modulation of growth and immunity by dietary supplementation with resveratrol in young chickens receiving conventional vaccinations

(2014) CaiYun Zhang et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

(2014) Anna Tresserra-Rimbau et al.   BMC Medicine

A dietary pattern rich in lignans, quercetin and resveratrol decreases the risk of oesophageal cancer

(2014) Yulan Lin et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression

(2014) Shakir M. Saud et al.   CARCINOGENESIS

Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates

(2014) Julie A. Mattison et al.   Cell Metabolism

Resveratrol mitigate structural changes and hepatic stellate cell activation in N′-nitrosodimethylamine-induced liver fibrosis via restraining oxidative damage

(2014) Areeba Ahmad et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-κB pathway

(2014) Rong Guo et al.   Diabetes & Vascular Disease Research

AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1

(2014) Hee Yun et al.   FEBS Journal

Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid

(2014) Justyna Mikuła-Pietrasik et al.   GYNECOLOGIC ONCOLOGY

Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1

(2014) Jianguo Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol Increases Bone Mineral Density and Bone Alkaline Phosphatase in Obese Men: A Randomized Placebo-Controlled Trial

(2014) Marie Juul Ornstrup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Resveratrol Inhibits the TRIF-Dependent Pathway by Upregulating Sterile Alpha and Armadillo Motif Protein, Contributing to Anti-Inflammatory Effects after Respiratory Syncytial Virus Infection

(2014) T. Liu et al.   JOURNAL OF VIROLOGY

Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3 inflammasome activation

(2014) Soo Jin Yang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study

(2014) A. Tresserra-Rimbau et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells

(2014) XIUYUAN OU et al.   ONCOLOGY REPORTS

Resveratrol Counteracts Inflammation in Human M1 and M2 Macrophages upon Challenge with 7-Oxo-Cholesterol: Potential Therapeutic Implications in Atherosclerosis

(2014) Brigitta Buttari et al.   Oxidative Medicine and Cellular Longevity

Regulatory effects of resveratrol on glucose metabolism and T-lymphocyte subsets in the development of high-fat diet-induced obesity in C57BL/6 mice

(2014) Bin Wang et al.   Food & Function

PTEN Mediates the Antioxidant Effect of Resveratrol at Nutritionally Relevant Concentrations

(2014) Marta Inglés et al.   Biomed Research International

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

(2014) Jerome C Nwachukwu et al.   eLife

Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats

(2013) Denise Ruttke Dillenburg et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Differential effects of resveratrol and its natural analogs, piceatannol and 3,5,4′-trans-trimethoxystilbene, on anti-inflammatory heme oxigenase-1 expression in RAW264.7 macrophages

(2013) Yong Son et al.   BIOFACTORS

Molecular interactions of hemoglobin with resveratrol: potential protective antioxidant role and metabolic adaptations of the erythrocyte

(2013) Ester Tellone et al.   BIOLOGICAL CHEMISTRY

Sex hormones and breast cancer risk and prognosis

(2013) Elizabeth Folkerd et al.   BREAST

Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease

(2013) Lake Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Dietary polyphenols and metabolic syndrome among Iranian adults

(2013) Golbon Sohrab et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells

(2013) C. Lee-Chang et al.   JOURNAL OF IMMUNOLOGY

Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

(2013) Lasse Gliemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Estimated Daily Flavonoid and Stilbene Intake from Fruits, Vegetables, and Nuts and Associations with Lipid Profiles in Chinese Adults

(2013) Guilan Li et al.   Journal of the Academy of Nutrition and Dietetics

High-Dose Resveratrol Supplementation in Obese Men: An Investigator-Initiated, Randomized, Placebo-Controlled Clinical Trial of Substrate Metabolism, Insulin Sensitivity, and Body Composition

(2012) M. M. Poulsen et al.   DIABETES

Alleviative effects of resveratrol on nonalcoholic fatty liver disease are associated with up regulation of hepatic low density lipoprotein receptor and scavenger receptor class B type I gene expressions in rats

(2012) Peng Xin et al.   FOOD AND CHEMICAL TOXICOLOGY

Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial

(2012) Joao Tomé-Carneiro et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

(2012) Weizhu Zhu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients

(2012) Raul Zamora-Ros et al.   PHARMACOLOGICAL RESEARCH

Sex/Gender Differences in Cardiovascular Disease Prevention

(2011) Lori Mosca et al.   CIRCULATION

Estrogen Signaling and Cardiovascular Disease

(2011) Elizabeth Murphy   CIRCULATION RESEARCH

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine transporter in human dopaminergic neurons and in striatum of female mice

(2011) Valentina Di Liberto et al.   NEUROPHARMACOLOGY

The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: Role of nitric oxide and superoxide

(2008) S. Soylemez et al.   VASCULAR PHARMACOLOGY