期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 33, 期 -, 页码 42-47出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2016.01.028
关键词
Resveratrol; Immunosuppressive mice; Immune function; NF-kappa B
资金
- National Natural Science Foundation of China [31372477]
- Sichuan Youth Science and Technology Innovation Research Team for Waterfowl Disease Prevention and Control [2013TD0015]
- Sichuan International Cooperation Projects [2014HH0058]
Resveratrol, a kind of natural product found in over 70 plants, possesses both immunomodulatory and anticancer effects. Many reports have shown that resveratrol has the bidirectional regulation effects on antigen presenting and cellular immunity. However, few reports have evaluated the effects of resveratrol on reinforcing immunity recovery via activating nuclear factor -Kappa B (NF-kappa B). In the present study, we investigated the effects of resveratrol on recovery and reconstruction of immune function by detecting nonspecific and specific immunity in immunosuppressive mice. We found that, compared to the immunosuppressive mice, the spleen index and spleen lymphocyte proliferation of resveratrol-treated mice (30 mg/kg body weight) were enhanced. After resveratrol-treatment (15 mg/kg body weight), the function of peritoneal macrophages was enhanced and the CD4+ cells were increased in peripheral blood. The expressions of serum cytokines related to immune function, including interleukin (IL)-1 alpha/beta, IL-2, tumor necrosis factor-alpha and NF-kappa B were up-regulated in a dose-dependent manner. The expression of the transcription factor NF-kappa B in spleen was enhanced after resveratrol-treatment The immuno-enhancement effects of resveratrol were similar to that of levamisole (served as positive control). These results demonstrated that resveratrol had potent immune enhancement activity in immunosuppressive mice, and one possible mechanism of action was to activate the NF-kappa B. (C) 2016 Elsevier B.V. All rights reserved.
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