Article
Endocrinology & Metabolism
Kikumi D. Ono-Moore, I. Mark Olfert, Jennifer M. Rutkowsky, Sree Chintapalli, Brandon J. Willis, Michael L. Blackburn, D. Keith Williams, Juliana O'Reilly, Todd Tolentino, K. C. Kent Lloyd, Sean H. Adams
Summary: Comprehensive metabolic studies showed that the loss of myoglobin does not significantly impact glucose homeostasis, EE, RER, or response to cold challenge in mice, indicating that myoglobin is not necessary for maintaining oxidative metabolism. However, there is a sex-specific effect of myoglobin knockout on fat storage and feed efficiency, as evident from the increased adiposity in female Mb-/- mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Andrea Berenyiova, Samuel Golas, Magdalena Drobna, Martina Cebova, Sona Cacanyiova
Summary: This study evaluated the impact of long-term fructose intake on vascular function in rats. It was found that chronic fructose consumption worsened endothelium-dependent vasorelaxation without affecting nitric oxide production. Additionally, fructose intake reduced the interaction between nitric oxide and hydrogen sulfide, leading to impaired vascular responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Karolini Zuqui Nunes, Fulvio Alexandre Scorza, Esper Abrao Cavalheiro, Dalton Valentim Vassallo
Summary: The authors investigated changes in vascular reactivity in rats following pilocarpine-induced status epilepticus. The results showed that epilepsy decreased the contractile responses of the aortic rings to phenylephrine. It was found that administration of L-NAME increased vascular reactivity, while administration of Catalase only decreased contractile responses in the rings of rats with epilepsy.
Article
Biochemistry & Molecular Biology
Jeremy Sprouse, Chethan Sampath, Pandu Gangula
Summary: Gastroparesis is a severe complication observed in women with diabetes mellitus, characterized by abnormal gastric emptying without mechanical obstruction. Our study demonstrates the protective effects of supplemental 17 beta-estradiol on NO-mediated gastric function. The administration of E-2 alleviates oxidative and inflammatory stress and improves metabolic homeostasis in diabetic mice.
Article
Biochemistry & Molecular Biology
Virginia Delli, Julien Dehame, Delphine Franssen, S. Rasika, Anne-Simone Parent, Vincent Prevot, Konstantina Chachlaki
Summary: This study found that the timing of minipuberty is different in male mice compared to females, but like females, nNOS activity in the preoptic region plays a crucial role in this process.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Food Science & Technology
Francineide Fernandes-Costa, Rayanelle Tissiane Gomes da Silva, Atalia Ferreira de Lima Flor, Maria Claudia R. Brandao, Petronio F. Athayde-Filho, Maria do Socorro Franca-Falcao, Valdir de Andrade Braga, Gustavo Jorge dos Santos, Mattias Carlstrom, Josiane de Campos Cruz
Summary: Our study investigated the cardiometabolic effect of NDBP treatment in a mouse model of type 1 diabetes (T1DM). The results showed that NDBP treatment reduced hyperglycemia, improved glucose tolerance, and decreased oxidative stress in the liver and pancreas. Additionally, NDBP treatment improved vascular function but had no effect on hypertension.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Physiology
Farjana Akther, Md Rahatullah Razan, Sonali Shaligram, James L. Graham, Kimber L. Stanhope, Kaitlin N. Allen, Jose Pablo Vazquez-Medina, Peter J. Havel, Roshanak Rahimian
Summary: This study found sexual differences in aortic function in UCD-T2DM rats, with females showing impaired contraction response and males exhibiting potentiated relaxation response. Diabetes led to reduced nitric oxide generation and insulin sensitivity, contributing to enhanced contractile responses in both sexes' aortas.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Emily Sze-Wan Wong, Rachel Wai-Sum Li, Jingjing Li, Renkai Li, Sai-Wang Seto, Simon Ming-Yuen Lee, George Pak-Heng Leung
Summary: Narirutin induces relaxation in rat mesenteric arteries through mechanisms involving phosphodiesterase inhibition, leading to increased intracellular cAMP, stimulation of endothelial nitric oxide synthase, and activation of voltage-gated potassium channels in vascular smooth muscle cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Carolina M. Lazaro, Jamaira A. Victorio, Ana Paula Davel, Helena C. F. Oliveira
Summary: The expression of CETP protects the vascular function in female animals and can improve endothelial dysfunction and the proatherogenic effect of cholesteryl ester transfer on atherosclerosis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Physiology
Takayuki Matsumoto, Keisuke Takayanagi, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
Summary: The study demonstrates that indoxyl sulfate enhances ET-1-induced contraction in rat aortas through impairment of NO/cGMP signaling and antioxidant systems.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Physiology
Lucia Piacenza, Ari Zeida, Madia Trujillo, Rafael Radi
Summary: The free radical nitric oxide (NO) plays a key role in physiological processes, but its bioavailability is compromised in certain disease conditions due to increased production of superoxide radical. This leads to the inactivation of nitric oxide and the formation of peroxynitrite, which is implicated in various human diseases and the aging process. Understanding the complex biochemistry of peroxynitrite is crucial for developing therapeutic interventions.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Junichi Fujii, Takujiro Homma, Tsukasa Osaki
Summary: Superoxide is a primary oxygen radical that plays a role in cellular defense. Hydrogen peroxide, produced as a result, can exacerbate diseases. Ferroptosis, induced by lipid peroxides in the presence of free iron, is associated with many diseases. Radical electrons, from mitochondrial complexes and enzymatic reactions, cause lipid peroxidation. GPX4 reduces lipid peroxides, and other antioxidants indirectly protect against ferroptosis. Low molecular weight compounds neutralize radical electrons, suppressing ferroptosis. Early removal of radical electrons is important for protection against ferroptosis and oxidative stress-related diseases.
Article
Pharmacology & Pharmacy
Fanrong Yao, Abdel A. Abdel-Rahman
Summary: The study reveals a protective role of tetrahydrobiopterin (BH4) against ethanol-induced cardiac dysfunction, and increasing BH4 levels can alleviate the adverse effects of ethanol.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medical Laboratory Technology
Huy Anh Bach, Phuong Nhung Vu, Thi Huyen Thuong Ma, Hai Ha Nguyen, Phan Tran Duc, Duc Bui Minh, Van Hai Nong, Dang Ton Nguyen
Summary: This case-control study investigated the association of antioxidant gene polymorphisms with male infertility in Vietnamese men. The research found that the SOD1:7958GA genotype and NOS3:-786CT genotype were significantly higher in the infertility group compared to the control group, and the frequency of the SOD2:c.47TC genotype was significantly higher in the male infertility group. Gene-gene interactions between SOD1, SOD2, and CAT SNPs might increase the risk of male infertility.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Neurosciences
Josiane Silva Silveira, Osmar Vieira Ramires Junior, Felipe Schmitz, Fernanda Silva Ferreira, Fabiana Cristina Rodrigues, Robson Coutinho Silva, Luiz Eduardo Baggio Savio, Angela T. S. Wyse
Summary: Supplementing with 4 mg/kg of folic acid during pregnancy can negatively affect the behavior and biochemical indicators of offspring.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mehmet Bilgehan Pektas, Halit Bugra Koca, Gokhan Sadi, Fatma Akar
BIOMED RESEARCH INTERNATIONAL
(2016)
Article
Pharmacology & Pharmacy
M. Bilgehan Pektas, Ozge Turan, Gozde Ozturk Bingol, Esra Sumlu, Goekhan Sadi, Fatma Akar
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2018)
Article
Toxicology
Onur Gokhan Yildirim, Esra Sumlu, Esra Aslan, Halit Bugra Koca, Mehmet Bilgehan Pektas, Gokhan Sadi, Fatma Akar
TOXICOLOGY MECHANISMS AND METHODS
(2019)
Article
Medicine, General & Internal
Omer A. Korkmaz, Esra Sumlu, H. Bugra Koca, M. Bilgehan Pektas, Aytac Kocabas, Gokhan Sadi, Fatma Akar
MEDICINA-LITHUANIA
(2019)
Article
Medicine, General & Internal
Yakup Kilic, Hasan N. Cetin, Esra Sumlu, Mehmet B. Pektas, Halit B. Koca, Fatma Akar
MEDICINA-LITHUANIA
(2019)
Article
Biochemistry & Molecular Biology
Esra Sumlu, Aykut Bostanci, Gokhan Sadi, Mehmet Eray Alcigir, Fatma Akar
Summary: The present study investigated the effects of Lactobacillus plantarum and Lactobacillus helveticus supplementation on liver lipogenesis, insulin signaling, and glucose transporters in high-fructose-fed rats. The results showed that supplementation with Lactobacillus plantarum improved liver health by reducing weight, lipid accumulation, and FASN expression, while also improving IRS-1/AKT/eNOS pathway and GLUT2 expression. On the other hand, Lactobacillus helveticus supplementation had a restoring effect on lipid accumulation by decreasing FASN expression and regulating IRS-1 and GLUT2 expressions.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Fatma Akar, Esra Sumlu, Mehmet Eray Alcigir, Aykut Bostanci, Gokhan Sadi
Summary: The study demonstrated that kefir supplementation improved metabolic parameters and modulated gut microbiota composition in high-fructose-fed rats, resulting in reduced inflammation and enhanced insulin signaling.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Andrology
Fatma Akar, Onur Gokhan Yildirim, Gozde Yucel Tenekeci, Arda Selin Tunc, Murside Ayse Demirel, Gokhan Sadi
Summary: Limited data suggests that a fructose-rich diet may have negative effects on testicular health in male rats, affecting tight junction proteins and mitogenic pathways. However, supplementing with kefir may help promote the expression of certain protective proteins and reduce testicular cell proliferation and apoptosis induced by fructose intake.
Article
Multidisciplinary Sciences
Ceren Guney, Nur Banu Bal, Fatma Akar
Summary: Excessive intake of fructose in the regular human diet is associated with global increases in metabolic disorders. Sugar-sweetened soft drinks, the main source of added fructose, can lead to gut permeability, inflammatory response, hepatic steatosis, abdominal adiposity, insulin resistance, and negative impacts on reproductive function. Recognizing the detrimental effects of fructose and implementing relevant public health policies are essential for preventing diet-related metabolic disorders.
Article
Reproductive Biology
Onur Gokhan Yildirim, Ceren Guney, Mehmet Eray Alcigir, Fatma Akar
Summary: High-fructose diet leads to suppression of testicular insulin signaling and activation of macrophage-related factors and apoptotic markers. These changes induced by dietary fructose could be associated with male reproductive dysfunction.
REPRODUCTIVE BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatma Akar, Ceren Guney, Hamdi Barbaros Ozer, Mehmet Bilgehan Pektas, Halit Bugra Koca, Aytac Kocabas, Gokhan Sadi
Summary: High-fructose intake upregulated angptl8 expression in adipose tissue but impaired other lipogenesis-related genes in rats. Kefir supplementation modulated fructose-induced changes, except for ppar gamma expression. These findings suggest a reciprocal effect of dietary fructose and kefir on lipogenesis-related genes in adipose tissue.
ISTANBUL JOURNAL OF PHARMACY
(2021)
Article
Pharmacology & Pharmacy
Ceren Guney, Fatma Akar
Summary: ACE2 acts as the main receptor for SARS-CoV-2 entry into host cells, playing a vital role in maintaining cardiovascular function and crucial in various physiological processes through the ACE/ACE2 balance. Its distribution in multiple organs is associated with disease target organs of SARS-CoV-2, and the modulation of ACE2 expression can impact viral cell entry and overall health.
JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Onur Gokhan Yildirim, Gokhan Sadi, Fatma Akar
ISTANBUL JOURNAL OF PHARMACY
(2020)
Article
Biology
Omer Adil Korkmaz, Gokhan Sadi, Aytac Kocabas, Onur Gokhan Yildirim, Esra Sumlu, Halit Bugra Koca, Barbaros Nalbantoglu, Mehmet Bilgehan Pektas, Fatma Akar
ARCHIVES OF BIOLOGICAL SCIENCES
(2019)
Article
Chemistry, Medicinal
Mehmet Bilgehan Pektas, Gozde Yucel, Halit Bugra Koca, Gokhan Sadi, Onur Gokhan Yildirim, Gozde Ozturk, Fatma Akar