Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood
出版年份 2020 全文链接
标题
Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood
作者
关键词
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出版物
GeroScience
Volume 42, Issue 2, Pages 727-748
出版商
Springer Science and Business Media LLC
发表日期
2020-03-15
DOI
10.1007/s11357-020-00180-6
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects
- (2020) Tamas Kiss et al. GeroScience
- Role of endothelial NAD+ deficiency in age-related vascular dysfunction
- (2019) Anna Csicsar et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment
- (2019) Tamas Kiss et al. GeroScience
- Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells
- (2019) Evan J. Morrison et al. Nutrients
- Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
- (2019) Stefano Tarantini et al. Redox Biology
- Systemic milieu and age-related deterioration
- (2019) Hongxia Zhang et al. GeroScience
- Nicotinamide mononucleotide (NMN) supplementation promotes anti-aging miRNA expression profile in the aorta of aged mice, predicting epigenetic rejuvenation and anti-atherogenic effects
- (2019) Tamas Kiss et al. GeroScience
- The enigmatic role of growth hormone in age-related diseases, cognition, and longevity
- (2019) Gabriela Colon et al. GeroScience
- Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction‐like phenotype in aged mice
- (2019) Lida Katsimpardi et al. AGING CELL
- Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging
- (2019) Stefano Tarantini et al. GeroScience
- Overexpression of catalase targeted to mitochondria improves neurovascular coupling responses in aged mice
- (2019) Anna Csiszar et al. GeroScience
- Fusogenic liposomes effectively deliver resveratrol to the cerebral microcirculation and improve endothelium-dependent neurovascular coupling responses in aged mice
- (2019) Tabea Wiedenhoeft et al. GeroScience
- Undulating changes in human plasma proteome profiles across the lifespan
- (2019) Benoit Lehallier et al. NATURE MEDICINE
- Treatment with the mitochondrial-targeted antioxidant peptide SS-31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice
- (2018) Stefano Tarantini et al. AGING CELL
- Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment
- (2018) Candice E. Van Skike et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Proteomics Reveals Rictor as a Non-Canonical TGFB Signaling Target During Aneurysm Progression in Marfan Mice
- (2018) Sarah J Parker et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging
- (2018) Abhirup Das et al. CELL
- NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR
- (2018) Jun Yoshino et al. Cell Metabolism
- IGF-1 Deficiency Promotes Pathological Remodeling of Cerebral Arteries: A Potential Mechanism Contributing to the Pathogenesis of Intracerebral Hemorrhages in Aging
- (2018) Gabor A Fulop et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline
- (2018) Marta Noa Valcarcel-Ares et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Endothelial dysfunction and angiogenesis impairment in the ageing vasculature
- (2018) Zoltan Ungvari et al. Nature Reviews Cardiology
- Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay
- (2018) Andrew D. Nguyen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain
- (2018) Geraldine Gontier et al. Cell Reports
- Loss of Rictor in Monocyte/Macrophages Suppresses Their Proliferation and Viability Reducing Atherosclerosis in LDLR Null Mice
- (2018) Vladimir R. Babaev et al. Frontiers in Immunology
- Mechanisms of Vascular Aging
- (2018) Zoltan Ungvari et al. CIRCULATION RESEARCH
- Adipose tissue senescence and inflammation in aging is reversed by the young milieu
- (2018) Amiya Kumar Ghosh et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
- (2018) Gabor A. Fulop et al. GeroScience
- The Reactome Pathway Knowledgebase
- (2017) Antonio Fabregat et al. NUCLEIC ACIDS RESEARCH
- Differential alternative splicing coupled to nonsense-mediated decay of mRNA ensures dietary restriction-induced longevity
- (2017) Syed Shamsh Tabrez et al. Nature Communications
- RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans
- (2017) Heehwa G. Son et al. Nature Communications
- Role of circulating factors in cardiac aging
- (2017) Antonio Cannatà et al. Journal of Thoracic Disease
- IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
- (2017) Nicole M. Ashpole et al. GeroScience
- IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis
- (2016) Stefano Tarantini et al. AGE
- Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging
- (2016) Stefano Tarantini et al. AGE
- Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways
- (2016) Lisa A. Lesniewski et al. AGING CELL
- Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access
- (2016) Caesar G. Imperio et al. BRAIN RESEARCH BULLETIN
- ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization
- (2016) Guangchuang Yu et al. Molecular BioSystems
- Ageing, neurodegeneration and brain rejuvenation
- (2016) Tony Wyss-Coray NATURE
- Near-optimal probabilistic RNA-seq quantification
- (2016) Nicolas L Bray et al. NATURE BIOTECHNOLOGY
- Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons
- (2016) Hélène Doucet-Beaupré et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood
- (2016) Justin Rebo et al. Nature Communications
- In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model
- (2016) Joseph M. Castellano et al. Scientific Reports
- Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
- (2016) Jinte Middeldorp et al. JAMA Neurology
- Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection
- (2015) Peter Toth et al. AGING CELL
- IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging
- (2015) Peter Toth et al. AGING CELL
- GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration
- (2015) Marc A. Egerman et al. Cell Metabolism
- Circulating Growth Differentiation Factor 11/8 Levels Decline With AgeNovelty and Significance
- (2015) Tommaso Poggioli et al. CIRCULATION RESEARCH
- GDF11 Does Not Rescue Aging-Related Pathological HypertrophyNovelty and Significance
- (2015) Shavonn C. Smith et al. CIRCULATION RESEARCH
- Reduced Circulating GDF11 Is Unlikely Responsible for Age-Dependent Changes in Mouse Heart, Muscle, and Brain
- (2015) Buel D. Rodgers et al. ENDOCRINOLOGY
- Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
- (2015) Renáta Váraljai et al. GENES & DEVELOPMENT
- IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms
- (2015) Nicole M Ashpole et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Growth differentiation factor 11 supports migration and sprouting of endothelial progenitor cells
- (2015) Günter Finkenzeller et al. JOURNAL OF SURGICAL RESEARCH
- Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries: Figure 1.
- (2015) Zsolt Springo et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis
- (2015) Lucas K Smith et al. NATURE MEDICINE
- Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
- (2015) Rachel J. Roth Flach et al. Nature Communications
- The Role of the Microenvironmental Niche in Declining Stem-Cell Functions Associated with Biological Aging
- (2015) Nathan A. DeCarolis et al. Cold Spring Harbor Perspectives in Medicine
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- (2014) Lindsey B. Gano et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Caloric restriction confers persistent anti-oxidative, pro-angiogenic, and anti-inflammatory effects and promotes anti-aging miRNA expression profile in cerebromicrovascular endothelial cells of aged rats
- (2014) Anna Csiszar et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Resveratrol Prevents High Fat/Sucrose Diet-Induced Central Arterial Wall Inflammation and Stiffening in Nonhuman Primates
- (2014) Julie A. Mattison et al. Cell Metabolism
- Rejuvenation: It’s in Our Blood
- (2014) Alessandro Bitto et al. Cell Metabolism
- IGF-1 Deficiency Impairs Cerebral Myogenic Autoregulation in Hypertensive Mice
- (2014) Peter Toth et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice
- (2014) Rachel A. Gioscia-Ryan et al. JOURNAL OF PHYSIOLOGY-LONDON
- Resveratrol Encapsulated in Novel Fusogenic Liposomes Activates Nrf2 and Attenuates Oxidative Stress in Cerebromicrovascular Endothelial Cells From Aged Rats
- (2014) Agnes Csiszár et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
- (2014) Saul A Villeda et al. NATURE MEDICINE
- Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors
- (2014) L. Katsimpardi et al. SCIENCE
- Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
- (2014) M. Sinha et al. SCIENCE
- Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration
- (2014) Christian Elabd et al. Nature Communications
- Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity
- (2013) Michael J. Conboy et al. AGING CELL
- Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase
- (2013) Peter Toth et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression
- (2013) Indranil Bhattacharya et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Causal analysis approaches in Ingenuity Pathway Analysis
- (2013) Andreas Krämer et al. BIOINFORMATICS
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
- (2013) Ana P. Gomes et al. CELL
- Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy
- (2013) Francesco S. Loffredo et al. CELL
- Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease
- (2013) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
- (2013) Tamara Tchkonia et al. JOURNAL OF CLINICAL INVESTIGATION
- Rejuvenating the ageing heart
- (2013) Alexandra Flemming NATURE REVIEWS DRUG DISCOVERY
- Insulin-like growth factor-1 in CNS and cerebrovascular aging
- (2013) William E. Sonntag et al. Frontiers in Aging Neuroscience
- Effects of Aging on Angiogenesis
- (2012) Johanna Lähteenvuo et al. CIRCULATION RESEARCH
- Mitochondria and Cardiovascular Aging
- (2012) Dao-Fu Dai et al. CIRCULATION RESEARCH
- Aging, Atherosclerosis, and IGF-1
- (2012) Y. Higashi et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Circulating Factors Induced by Caloric Restriction in the Nonhuman Primate Macaca Mulatta Activate Angiogenic Processes in Endothelial Cells
- (2012) A. Csiszar et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The Emerging Role of IGF-1 Deficiency in Cardiovascular Aging: Recent Advances
- (2012) Z. Ungvari et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Age-Associated Proinflammatory Secretory Phenotype in Vascular Smooth Muscle Cells From the Non-human Primate Macaca mulatta: Reversal by Resveratrol Treatment
- (2012) A. Csiszar et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue
- (2012) Hassina Massudi et al. PLoS One
- Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response
- (2011) Zoltan Ungvari et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
- (2011) Sergiy Libert et al. CELL
- PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
- (2011) Shinichi Oka et al. Cell Metabolism
- Growth Hormone and IGF-1 Deficiency Exacerbate High-Fat Diet-Induced Endothelial Impairment in Obese Lewis Dwarf Rats: Implications for Vascular Aging
- (2011) L. C. Bailey-Downs et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging
- (2011) L. C. Bailey-Downs et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function
- (2011) Saul A. Villeda et al. NATURE
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
- (2011) Darren J. Baker et al. NATURE
- Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression
- (2011) M. Mitschelen et al. NEUROSCIENCE
- PGC-1 coactivators in the cardiovascular system
- (2011) Ian S. Patten et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Posttransplantation Therapeutic Rapamycin Concentration Protects Nitric Oxide–Related Vascular Endothelial Function: Comparative Effects in Rat Thoracic Aorta and Coronary Endothelial Cell Culture
- (2010) A. Parlar et al. TRANSPLANTATION PROCEEDINGS
- Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus
- (2009) Nazar Labinskyy et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
- (2009) Anna Csiszar et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
- (2009) Steffen Durinck et al. Nature Protocols
- Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats
- (2008) Zoltan Ungvari et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
- (2008) Kevin J. Pearson et al. Cell Metabolism
- Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
- (2008) Yueting Shang et al. JOURNAL OF CELL BIOLOGY
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