Aging, Atherosclerosis, and IGF-1

Low circulating insulin-like growth factor I increases atherosclerosis in ApoE-deficient mice

(2011) Shaw-Yung Shai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial Progenitor Cells: A Novel Tool for the Therapy of Ischemic Diseases

(2011) Cantas Alev et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of insulin-like growth factor 1 in preventing acute coronary syndromes: The PRIME study

(2011) J.B. Ruidavets et al.   ATHEROSCLEROSIS

The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation

(2011) Jing Wang et al.   ATHEROSCLEROSIS

The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium

(2011) A. Abbas et al.   DIABETES

Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effects

(2011) Sergiy Sukhanov et al.   FEBS LETTERS

Early vascular aging and the role of central blood pressure

(2011) Vasilios Kotsis et al.   JOURNAL OF HYPERTENSION

Liver-Specific Knockdown of IGF-1 Decreases Vascular Oxidative Stress Resistance by Impairing the Nrf2-Dependent Antioxidant Response: A Novel Model of Vascular Aging

(2011) L. C. Bailey-Downs et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in Apoe −/− Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability

(2010) Shaw-Yung Shai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice

(2010) David W. Hammers et al.   EXPERIMENTAL GERONTOLOGY

Thiazolidinediones Up-regulate Insulin-like Growth Factor-1 Receptor via a Peroxisome Proliferator-activated Receptor γ-Independent Pathway

(2010) Yusuke Higashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

TGF-β1 Limits Plaque Growth, Stabilizes Plaque Structure, and Prevents Aortic Dilation in Apolipoprotein E-Null Mice

(2009) Andrew D. Frutkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nox2-Containing NADPH Oxidase Deficiency Confers Protection From Hindlimb Ischemia in Conditions of Increased Oxidative Stress

(2009) Paola Haddad et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells

(2009) Niels Engberding et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Growth Hormone-Releasing Peptide-2 Suppresses Vascular Oxidative Stress in ApoE−/−Mice But Does Not Reduce Atherosclerosis

(2009) Jane S. Titterington et al.   ENDOCRINOLOGY

Vascular Insulin-Like Growth Factor-I Resistance and Diet-Induced Obesity

(2009) Helen Imrie et al.   ENDOCRINOLOGY

Insulin and Insulin-Like Growth Factor-I Receptors Differentially Mediate Insulin-Stimulated Adhesion Molecule Production by Endothelial Cells

(2009) Guolian Li et al.   ENDOCRINOLOGY

Mortality and Serum Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein 3 Concentrations

(2009) Nele Friedrich et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats

(2009) Isabelle Rieu et al.   JOURNAL OF PHYSIOLOGY-LONDON

12/15-Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3-L1 Adipocytes

(2009) Swarup K. Chakrabarti et al.   Obesity

The role of systemic inflammation in age-related muscle weakness and wasting

(2009) H. Degens   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Emerging biology of vascular wall progenitor cells in health and disease

(2009) Derya Tilki et al.   TRENDS IN MOLECULAR MEDICINE

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

(2008) Anna Csiszar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: Findings from the prospective British Women's Heart and Health Study

(2008) Debbie A. Lawlor et al.   ATHEROSCLEROSIS

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice

(2008) Georgios Foteinos et al.   CIRCULATION

Role of Nox2-Based NADPH Oxidase in Bone Marrow and Progenitor Cell Function Involved in Neovascularization Induced by Hindlimb Ischemia

(2008) Norifumi Urao et al.   CIRCULATION RESEARCH

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH

Reciprocal Association of Plasma IGF-1 and Interleukin-6 Levels With Cardiometabolic Risk Factors in Nondiabetic Subjects

(2008) E. Succurro et al.   DIABETES CARE

Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects

(2008) Annamaria Colao et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

IGF1 as predictor of all cause mortality and cardiovascular disease in an elderly population

(2008) Mikkel Andreassen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Role of IGF-system in Vascular Insulin Resistance

(2008) H. Arnqvist   HORMONE AND METABOLIC RESEARCH

Inflammation and endothelial dysfunction during aging: role of NF-κB

(2008) Anna Csiszar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Associations of Insulin-Like Growth Factor (IGF)-I, IGF-II, IGF Binding Protein (IGFBP)-2 and IGFBP-3 with Ultrasound Measures of Atherosclerosis and Plaque Stability in an Older Adult Population

(2008) Richard M. Martin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low Circulating Insulin-Like Growth Factor I Bioactivity in Elderly Men Is Associated with Increased Mortality

(2008) M. P. Brugts et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Low-Plasma Insulin-Like Growth Factor-I Levels Are Associated with Impaired Endothelium-Dependent Vasodilatation in a Cohort of Untreated, Hypertensive Caucasian Subjects

(2008) Francesco Perticone et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Activated thrombin activatable fibrinolysis inhibitor levels are associated with the risk of cardiovascular death in patients with coronary artery disease: the AtheroGenestudy

(2008) D. A. TREGOUET et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation of serum IGF-I and IGFBP-1 and -3 to cardiovascular risk indicators and early carotid atherosclerosis in healthy middle-aged men

(2007) S. Boquist et al.   CLINICAL ENDOCRINOLOGY

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

(2007) Colin Selman et al.   FASEB JOURNAL