Article
Biochemistry & Molecular Biology
Javier Saenz-Medina, Maria Martinez, Silvia Rosado, Manuel Duran, Dolores Prieto, Joaquin Carballido
Summary: The study aimed to investigate the endothelial vascular function in patients with urolithiasis in relation to systemic inflammatory, oxidative stress, and vascular function serum markers. It found that endothelial dysfunction is an important disorder in urolithiasis patients and may be related to future cardiovascular events, although no significant association was found between inflammatory, oxidative stress, endothelial serum markers, and flow-mediated dilation.
Article
Behavioral Sciences
Carey E. Lyons, Maria Razzoli, Alessandro Bartolomucci
Summary: Chronic stress has been shown to increase the risk of aging-related diseases and shorten lifespan, but the mechanisms behind these effects are still unclear. Recent research suggests that stress may lead to dysregulation of the hallmarks of aging, which are biological mechanisms that can accelerate aging when altered. This review examines the evidence for the contribution of stress, particularly from adverse social environments, to the activation of these hallmarks, such as cellular senescence, inflammation, telomere shortening, DNA damage, and epigenetic changes. The validity of stress-induced senescence and accelerated aging as an etiological proposition is also evaluated.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Review
Cell Biology
Nadia Di Pietrantonio, Pamela Di Tomo, Domitilla Mandatori, Gloria Formoso, Assunta Pandolfi
Summary: Diabetes accelerates vascular senescence, leading to chronic inflammation and oxidative stress, which in turn cause endothelial dysfunction and related cardiovascular complications. The acetyltransferase p300 has been suggested to play a crucial role in diabetes-associated inflammation and oxidative stress, potentially contributing to the development of vascular senescence. Understanding the mechanisms of p300 in diabetic vascular dysfunction could aid in finding new therapeutic strategies for cardiovascular diseases related to diabetes.
Article
Cell Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Cristina Contreras, Ana Sanchez, Maria Jose Coronado, Elvira Ramil, Martin Santos, Joaquin Carballido, Dolores Prieto
Summary: This study found that urolithiasis leads to endothelial dysfunction in preglomerular arteries, accompanied by an increase in renal cortex superoxide generation and the development of vascular inflammation. Pathways involving xanthine oxidase, Nox1, and Nox2 also play a role in this process.
Review
Biochemistry & Molecular Biology
Tatsuya Maruhashi, Yukihito Higashi
Summary: Endothelial dysfunction is crucial in the progression of atherosclerosis and is significantly associated with diabetes mellitus and oxidative stress. Selecting appropriate therapeutic interventions that improve endothelial function is important for preventing diabetic vascular complications. Various hypoglycemic drugs and agents like GLP-1 receptor agonists and SGLT2 inhibitors may improve endothelial function through multiple mechanisms independent of glucose control or insulin signaling.
Article
Biology
Francisco R. Jimenez Trinidad, Marta Arrieta Ruiz, Nuria Solanes Batllo, Angela Vea Badenes, Joaquim Bobi Gibert, Antoni Valera Canellas, Merce Roque Moreno, Xavier Freixa Rofastes, Manel Sabate Tenas, Ana Paula Dantas, Olga Tura-Ceide, Montserrat Rigol Muxart
Summary: Endothelial cell dysfunction is a key factor in several cardiovascular diseases, and developing in vitro models is crucial for understanding the pathophysiology and aiding in the development of new pharmacological therapies. The study validated models of cellular dysfunction associated with senescence induced by starvation and oxidative stress, demonstrating changes in cellular function and dysfunction markers. These models can improve physiological studies of endothelial cell dysfunction and allow rapid testing of future therapeutic compounds for efficacy and toxicity.
Article
Medicine, Research & Experimental
Ying Zhou, Shi Tai, Ningjie Zhang, Liyao Fu, Yongjun Wang
Summary: Recent studies have shown that dapagliflozin can improve endothelial dysfunction caused by oxidative stress by restoring endothelial nitric oxide synthase activity, increasing nitric oxide bioavailability, and reducing reactive oxygen species generation. Dapagliflozin exerts a direct vasorelaxant effect and improves endothelium-dependent vasorelaxation in diabetic mice. Furthermore, dapagliflozin inhibits hydrogen peroxide-induced senescence in endothelial cells by reversing the inhibition of endothelial nitric oxide synthase serine phosphorylation and sirtuin 1 expression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Geriatrics & Gerontology
Sergei Romashkan, Henry Chang, Evan C. Hadley
Summary: Cell senescence is linked to various age-related conditions, and there is interest in repurposing drugs to treat these diseases. Future research should focus on finding better and more specific senolytics and senomorphics, as well as implementing standardized measures for data comparison and sharing.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Cell Biology
Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Wanlin Ye, Yi Kang, Guo Chen, Tao Zhu
Summary: The blood-brain barrier (BBB) is a crucial barrier that separates the central nervous system from the periphery, consisting of endothelial cells, pericytes, astrocytes, synapses, and tight junction proteins. During the perioperative period, anesthesia and surgical procedures pose stress on the body, leading to potential blood-brain barrier damage and brain metabolism dysfunction. The destruction of the blood-brain barrier during the perioperative period is closely associated with cognitive impairment and increased risk of postoperative mortality, hindering the enhancement of recovery after surgery. The specific pathophysiological processes and mechanisms underlying blood-brain barrier damage during the perioperative period have not been fully elucidated, but changes in blood-brain barrier permeability, inflammation and neuroinflammation, oxidative stress, ferroptosis, and intestinal dysbiosis may be involved. This review aims to summarize the research progress on perioperative blood-brain barrier damage, its potential adverse effects, and molecular mechanisms to provide insights for the study of brain function homeostasis and precision anesthesia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Review
Biochemistry & Molecular Biology
Katarzyna Pankiewicz, Tadeusz Issat
Summary: Chemerin is a versatile adipokine involved in various biological processes, including inflammation, angiogenesis, adipogenesis, energy metabolism, and oxidative stress. It plays a crucial role in the development of cardiovascular diseases, particularly in pre-eclampsia (PE). Elevated levels of blood chemerin and its placental expression are positively correlated with the severity of PE. This review provides an overview of the potential role of chemerin in PE development, focusing on its involvement in oxidative stress and endothelial dysfunction.
Article
Biochemistry & Molecular Biology
Alice Dauth, Andrzej Breborowicz, Yue Ruan, Qi Tang, Jenia K. Zadeh, Elsa W. Bohm, Norbert Pfeiffer, Pratik H. Khedkar, Andreas Patzak, Ksenija Vujacic-Mirski, Andreas Daiber, Adrian Gericke
Summary: This study aimed to examine the protective effect of sulodexide, a mixture of glycosaminoglycans, against hyperglycemia-induced endothelial dysfunction in the retina. Using isolated porcine retinal arterioles, the researchers found that sulodexide had a concentration-dependent protective effect against endothelial dysfunction and oxidative stress by modulating the expression of redox enzymes.
Review
Immunology
Dominique E. Martin, Blake L. Torrance, Laura Haynes, Jenna M. Bartley
Summary: Immunometabolism plays a crucial role in aging, affecting immune cell activation and effector functions through metabolic pathways. It has been found that aging can impact the networks controlling immune cell metabolism, but further research is needed to fully understand these effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Immunology
Nada J. Habeichi, Cynthia Tannous, Andriy Yabluchanskiy, Raffaele Altara, Mathias Mericskay, George W. Booz, Fouad A. Zouein
Summary: This review explores the potential impact of SARS-CoV-2 on interferon secretion and mitochondrial NAD(+) depletion, and discusses the benefits of adjusting immune response and mitochondrial function in the context of the COVID-19 pandemic.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Akos Menyhart, Rita Frank, Attila E. Farkas, Zoltan Sule, Viktoria E. Varga, Adam Nyul-Toth, Anne Meiller, Orsolya Ivankovits-Kiss, Coline L. Lemale, Irisz Szabo, Reka Toth, Daniel Zolei-Szenasi, Johannes Woitzik, Stephane Marinesco, Istvan A. Krizbai, Ferenc Bari, Jens P. Dreier, Eszter Farkas
Summary: Acute brain swelling impairs astroglial glutamate clearance and leads to extracellular glutamate accumulation and the occurrence of SiD, a pathological spreading depolarization associated with astrocyte swelling and neuronal death. Preventive osmotherapy may be necessary in acute brain injury to mitigate the effects of SiD.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Critical Care Medicine
Akos Menyhart, Daniel Peter Varga, Orsolya M. Toth, Peter Makra, Ferenc Bari, Eszter Farkas
Summary: The study investigates the interplay between impaired cerebrovascular autoregulation, SD occurrence, and the evolution of the SD-coupled CBF response in acute brain injury, suggesting dysfunction of autoregulation poses a risk of SD occurrence and damages neurovascular coupling.
NEUROCRITICAL CARE
(2022)
Article
Geriatrics & Gerontology
Tamas Kiss, Adam Nyul-Toth, Rafal Gulej, Stefano Tarantini, Tamas Csipo, Peter Mukli, Anna Ungvari, Priya Balasubramanian, Andriy Yabluchanskiy, Zoltan Benyo, Shannon M. Conley, Jonathan D. Wren, Lori Garman, Derek M. Huffman, Anna Csiszar, Zoltan Ungvari
Summary: Vascular aging plays a central role in the development of cardiovascular diseases, leading to increased mortality in older adults. Both cell-autonomous and cell-nonautonomous mechanisms contribute to the regulation of vascular aging processes. Recent studies have shown that circulating anti-geronic factors from young blood can promote vascular rejuvenation in aged mice. This study further investigated the role of circulating pro-geronic factors in the development of vascular aging phenotypes. The findings suggest that old blood can accelerate vascular aging processes, contributing to pathological vascular remodeling mediated by specific transcriptional regulators.
Article
Geriatrics & Gerontology
Tamas Kiss, Adam Nyul-Toth, Jordan DelFavero, Priya Balasubramanian, Stefano Tarantini, Janet Faakye, Rafal Gulej, Chetan Ahire, Anna Ungvari, Andriy Yabluchanskiy, Graham Wiley, Lori Garman, Zoltan Ungvari, Anna Csiszar
Summary: There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. Using spatial transcriptomics analysis, researchers found that senescent cells accumulate in the white matter, hippocampi, and cortical grey matter of aged mice, potentially contributing to neuroinflammation.
Article
Cardiac & Cardiovascular Systems
Cameron D. Owens, Peter Mukli, Tamas Csipo, Agnes Lipecz, Federico Silva-Palacios, Tarun W. Dasari, Stefano Tarantini, Andrew W. Gardner, Polly S. Montgomery, Shari R. Waldstein, J. Mikhail Kellawan, Adam Nyul-Toth, Priya Balasubramanian, Peter Sotonyi, Anna Csiszar, Zoltan Ungvari, Andriy Yabluchanskiy
Summary: Peripheral artery disease (PAD) is associated with cognitive decline, which may be due to microvascular endothelial dysfunction and neurovascular uncoupling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Immunology
Eszter Csaszar, Nikolett Lenart, Csaba Cserep, Zsuzsanna Koernyei, Rebeka Fekete, Balazs Posfai, Diana Balazsfi, Balazs Hangya, Anett D. Schwarcz, Eszter Szabadits, David Szoellosi, Krisztian Szigeti, Domokos Mathe, Brian L. West, Katalin Sviatko, Ana Rita Bras, Jean-Charles Mariani, Andrea Kliewer, Zsolt Lenkei, Laszlo Hricisak, Zoltan Benyo, Maria Baranyi, Beata Sperlagh, Akos Menyhart, Eszter Farkas, Adam Denes
Summary: Microglia play an important role in cerebral blood flow regulation through complex purinergic actions, which are mediated by dynamic interactions with the vasculature and are partially independent of nitric oxide. This study reveals a previously unrecognized role for microglia in regulating cerebral blood flow and has broad implications for common neurological diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Critical Care Medicine
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Mueller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Summary: The spreading depolarizations (SD) theory provides a better explanation for acute neuronal injury caused by brain ischemia than the theory of excessive glutamate release. The challenges in developing therapeutic strategies based on more informed basic science are highlighted, calling for a shift in focus towards understanding the molecular biology of SD initiation and propagation.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei A. Kirov, Michael Muller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Summary: In this review, the mechanism and impact of spreading depolarization (SD) in the gray matter following blood flow loss are discussed. The initiation and propagation of SD are explored, along with the challenges and pitfalls in studying SD. The review concludes with a summary of the research direction and ongoing debates regarding SD.
NEUROCRITICAL CARE
(2022)
Article
Endocrinology & Metabolism
Anna Toerteli, Reka Toth, Sarah Berger, Sarah Samardzic, Ferenc Bari, Akos Menyhart, Eszter Farkas
Summary: Despite successful recanalization, reperfusion failure associated with poor neurological outcomes develops in half of treated stroke patients. We explore here whether spreading depolarization (SD) is a predictor of reperfusion failure.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cell Biology
Stefano Tarantini, Madhan Subramanian, Joshua T. Butcher, Andriy Yabluchanskiy, Xinna Li, Richard A. Miller, Priya Balasubramanian
Summary: Adipose tissue undergoes significant changes with age, including altered secretion of adipokines, decreased adipogenesis, altered immune cell profile, and increased inflammation. Dysfunctional adipose metabolism in aging may contribute to a higher risk of metabolic diseases. Increasing thermogenesis in adipose tissue has shown potential in improving metabolism and treating obesity-related disorders, but challenges exist in applying this strategy to the elderly population. This review summarizes the current understanding of aging and thermogenesis and explores opportunities to target thermogenic mechanisms for delaying aging and age-related diseases, as well as the role of thermogenic adipocytes in healthspan and lifespan extension.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Akos Menyhart, Armand Rafael Balint, Peter Kozak, Ferenc Bari, Eszter Farkas
Summary: This study investigated the progressive restoration of impaired neurovascular coupling and the effect of nimodipine treatment after cerebral oligemia. The results showed that nimodipine accelerated the recovery of cerebral blood flow and functional hyperemia after oligemia, suggesting its potential use in migraine prophylaxis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Szilvia Kecskes, Akos Menyhart, Ferenc Bari, Eszter Farkas
Summary: This study discovered a decline in cerebrovascular reactivity (CVR) and cellular senescence in the brains of old rats. Additionally, CVR impairment was observed in acute cerebral ischemia. The use of nimodipine showed mixed effects, improving CVR in aging brains but worsening it in acute ischemia.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Baoqiang Li, Andriy Yabluchanskiy, Stefano Tarantini, Srinivasa Rao Allu, Ikbal Sencan-Egilmez, Ji Leng, Mohammed Ali H. Alfadhel, Jason E. Porter, Buyin Fu, Chongzhao Ran, Sefik Evren Erdener, David A. Boas, Sergei A. Vinogradov, William E. Sonntag, Anna Csiszar, Zoltan Ungvari, Sava Sakadzic
Summary: Whole-brain irradiation is a common treatment for brain metastases, but it can cause cognitive decline. This study suggests that radiation-induced injury to cerebral microvasculature and neurovascular senescence may be responsible for this side effect.
Article
Mathematics, Interdisciplinary Applications
Orestis Stylianou, Zalan Kaposzta, Akos Czoch, Leon Stefanovski, Andriy Yabluchanskiy, Frigyes Samuel Racz, Petra Ritter, Andras Eke, Peter Mukli
Summary: This study explores the scale-free functional connectivity in Parkinson's disease patients and how it is affected by dopaminergic treatment. The results demonstrate that dopaminergic treatment alters the multifractal coupled dynamics in the brain, warranting further investigation in clinical and pharmacological studies.
FRACTAL AND FRACTIONAL
(2022)