标题
Hypoxia-Induced Epithelial-Mesenchymal Transition in Cancers: HIF-1α and Beyond
作者
关键词
-
出版物
Frontiers in Oncology
Volume 10, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-04-08
DOI
10.3389/fonc.2020.00486
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- JNK Pathway Mediates Low Oxygen Level Induced Epithelial–Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer Cells
- (2020) Shing Yau Tam et al. Cancers
- Hypoxia-Activated PI3K/Akt Inhibits Oxidative Stress via the Regulation of Reactive Oxygen Species in Human Dental Pulp Cells
- (2019) Fei Liu et al. Oxidative Medicine and Cellular Longevity
- ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation
- (2019) Sejeong Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- WNT1-inducible signaling pathway protein 1 (WISP1/CCN4) stimulates melanoma invasion and metastasis by promoting the epithelial - mesenchymal transition
- (2019) Wentao Deng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis
- (2019) Wei Lu et al. DEVELOPMENTAL CELL
- Dynamics of oxygen level-driven regulators in modulating autophagy in colorectal cancer cells
- (2019) Shing Yau Tam et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Prognostic value of ZEB-1 in solid tumors: a meta-analysis
- (2019) Borong Chen et al. BMC CANCER
- Transcriptional regulation of FoxM1 by HIF‑1α mediates hypoxia‑induced EMT in prostate cancer
- (2019) Cong Tang et al. ONCOLOGY REPORTS
- NEDD9 promotes invasion and migration of colorectal cancer cell line HCT116 via JNK/EMT
- (2019) Haining Meng et al. Oncology Letters
- Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
- (2019) Muhammad Zaeem Noman et al. Cells
- FGFR3 promotes the growth and malignancy of melanoma by influencing EMT and the phosphorylation of ERK, AKT, and EGFR
- (2019) Lei Li et al. BMC CANCER
- A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer
- (2019) Rohan Kar et al. Genes
- PAFAH1B2 is a HIF1a target gene and promotes metastasis in pancreatic cancer
- (2018) Can Ma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Advances in Hypoxia-Inducible Factor Biology
- (2018) Hani Choudhry et al. Cell Metabolism
- Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT
- (2018) Ernestina De Francesco et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells by Twist1 upregulation
- (2018) Meera Saxena et al. JOURNAL OF CELL SCIENCE
- Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription
- (2018) Shi-jiang Deng et al. ONCOGENE
- Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC
- (2018) Joel P. Joseph et al. ORAL ONCOLOGY
- HIF-1α promotes ZEB1 expression and EMT in a human bladder cancer lung metastasis animal model
- (2018) Jianning Zhu et al. Oncology Letters
- Hypoxia-Driven Immunosuppressive Metabolites in the Tumor Microenvironment: New Approaches for Combinational Immunotherapy
- (2018) Yiliang Li et al. Frontiers in Immunology
- Chronic hypoxia-induced slug promotes invasive behavior of prostate cancer cells by activating expression of ephrin-B1
- (2018) Kazunori Iwasaki et al. CANCER SCIENCE
- Hypoxia-Inducible Factor 1α Regulates the Transforming Growth Factor β1/SMAD Family Member 3 Pathway to Promote Breast Cancer Progression
- (2018) Jianheng Peng et al. Journal of Breast Cancer
- Temporal lobe injury patterns following intensity modulated radiotherapy in a large cohort of nasopharyngeal carcinoma patients
- (2018) Lixia Lu et al. ORAL ONCOLOGY
- Irisin inhibits pancreatic cancer cell growth via the AMPK-mTOR pathway
- (2018) Jiayu Liu et al. Scientific Reports
- Hypoxia Stimulates the Epithelial–to–Mesenchymal Transition in Lung Cancer Cells Through Accumulation of Nuclear β-Catenin
- (2018) KAO-HUI LIU et al. ANTICANCER RESEARCH
- Betulinic acid inhibits stemness and EMT of pancreatic cancer cells via activation of AMPK signaling
- (2018) Liankang Sun et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Non-redundant functions of EMT transcription factors
- (2018) Marc P. Stemmler et al. NATURE CELL BIOLOGY
- New insights into the role of EMT in tumor immune escape
- (2017) Stéphane Terry et al. Molecular Oncology
- Influence of autophagy on the efficacy of radiotherapy
- (2017) Shing Yau Tam et al. Radiation Oncology
- Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway
- (2017) Weiwei Sheng et al. Cell Death & Disease
- miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells
- (2017) Yongmei Chang et al. Oncology Letters
- Fibronectin induces epithelial-mesenchymal transition in human breast cancer MCF-7 cells via activation of calpain
- (2017) Cheng-Lin Li et al. Oncology Letters
- The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation
- (2017) Chang Dong Yeo et al. KOREAN JOURNAL OF INTERNAL MEDICINE
- NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells
- (2017) Bruno R. B. Pires et al. PLoS One
- EMT: 2016
- (2016) M. Angela Nieto et al. CELL
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- Epithelial-mesenchymal transition regulated by p38/MAPK signaling pathways participates in vasculogenic mimicry formation in SHG44 cells transfected with TGF-β cDNA loaded lentivirus in vitro and in vivo
- (2016) Gengqiang Ling et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- HIF-2α promotes epithelial-mesenchymal transition through regulating Twist2 binding to the promoter of E-cadherin in pancreatic cancer
- (2016) Jian Yang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The ERK–ZEB1 pathway mediates epithelial–mesenchymal transition in pemetrexed resistant lung cancer cells with suppression by vinca alkaloids
- (2016) L-Y Chiu et al. ONCOGENE
- p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma
- (2016) Yuan Lin et al. ORAL ONCOLOGY
- Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
- (2016) Caroline Wigerup et al. PHARMACOLOGY & THERAPEUTICS
- HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer
- (2016) Yiseul Choi et al. WORLD JOURNAL OF GASTROENTEROLOGY
- c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas
- (2016) Dieter H. Heiland et al. Oncotarget
- Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells
- (2015) M Ricciardi et al. BRITISH JOURNAL OF CANCER
- Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α–ZEB1 axis
- (2015) Justin V. Joseph et al. CANCER LETTERS
- The emerging role of hypoxia-inducible factor-2 involved in chemo/radioresistance in solid tumors
- (2015) Jiuda Zhao et al. CANCER TREATMENT REVIEWS
- Increased Levels of β-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with NegativeBRAFandNRASMutation inBRAFExons 11 and 15 andNRASExons 1 and 2
- (2015) Sanxiong Xu et al. DNA AND CELL BIOLOGY
- Regulation of Hypoxia-Inducible Factor-1a by Reactive Oxygen Species : New Developments in an Old Debate
- (2015) Shahrzad Movafagh et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Next-Generation Pathology—Surveillance of Tumor Microecology
- (2015) Björn Koos et al. JOURNAL OF MOLECULAR BIOLOGY
- Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K
- (2015) Rupert Courtnay et al. MOLECULAR BIOLOGY REPORTS
- Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner
- (2015) Shan Shao et al. Molecular Cancer
- Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt Activation
- (2015) Yong-Qu Zhang et al. PLoS One
- Hypoxia and Predicting Radiation Response
- (2015) Richard P. Hill et al. SEMINARS IN RADIATION ONCOLOGY
- A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells
- (2015) Chih-Chien Chou et al. Oncotarget
- HIF-1α pathway: role, regulation and intervention for cancer therapy
- (2015) Georgina N. Masoud et al. Acta Pharmaceutica Sinica B
- HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer
- (2015) Wenjing Zhang et al. PLoS One
- AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis
- (2014) Chih-Chien Chou et al. CANCER RESEARCH
- Cell cycle progression in response to oxygen levels
- (2014) Brian Ortmann et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role
- (2014) XIAOJIN ZHANG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Role of TWIST in Ovarian Epithelial Cancers
- (2014) Kyungbin Kim et al. Korean Journal of Pathology
- TWIST1 and SNAI1 as markers of poor prognosis in human colorectal cancer are associated with the expression of ALDH1 and TGF-β1
- (2014) YONG HUN KIM et al. ONCOLOGY REPORTS
- Signaling mechanisms of the epithelial-mesenchymal transition
- (2014) D. M. Gonzalez et al. Science Signaling
- Inhibition of phosphoinositide 3-kinase/Akt pathway decreases hypoxia inducible factor-1α expression and increases therapeutic efficacy of paclitaxel in human hypoxic gastric cancer cells
- (2014) JING ZHANG et al. Oncology Letters
- NF- B, an Active Player in Human Cancers
- (2014) Y. Xia et al. Cancer Immunology Research
- The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer
- (2013) Martha E Kidd et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- JNK signaling maintains the mesenchymal properties of multi-drug resistant human epidermoid carcinoma KB cells through snail and twist1
- (2013) Xia Zhan et al. BMC CANCER
- Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma
- (2013) Lin Zhang et al. BMC CANCER
- Wnt/β-catenin signaling enhances hypoxia-induced epithelial–mesenchymal transition in hepatocellular carcinoma via crosstalk with hif-1α signaling
- (2013) Qi Zhang et al. CARCINOGENESIS
- Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
- (2013) Jianjun Lei et al. Molecular Cancer
- Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis
- (2013) Jiali Zhang et al. ORAL ONCOLOGY
- Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy
- (2013) InYoung Kim et al. Frontiers in Oncology
- Targeting a cornerstone of radiation resistance: Cancer stem cell
- (2012) Coralie Moncharmont et al. CANCER LETTERS
- c-Myc expression and MEK1-induced Erk2 nuclear localization are required for TGF-beta induced epithelial–mesenchymal transition and invasion in prostate cancer
- (2012) Michael D. Amatangelo et al. CARCINOGENESIS
- Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential
- (2012) Alexei V. Salnikov et al. PLoS One
- Epigenetic reprogramming and post-transcriptional regulation during the epithelial–mesenchymal transition
- (2012) Chung-Yin Wu et al. TRENDS IN GENETICS
- Notch Signaling
- (2012) R. Kopan Cold Spring Harbor Perspectives in Biology
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
- (2011) J. Hong et al. CANCER RESEARCH
- The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice
- (2011) Yanan Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Expression of Hypoxia-inducible Factor 1α Predicts Clinical Outcome after Preoperative Hyperthermo-chemoradiotherapy for Locally Advanced Rectal Cancer
- (2011) Mariko SHIOYA et al. JOURNAL OF RADIATION RESEARCH
- Dynamic actin remodeling during epithelial–mesenchymal transition depends on increased moesin expression
- (2011) Jennifer Haynes et al. MOLECULAR BIOLOGY OF THE CELL
- Mechanism of the Mesenchymal-Epithelial Transition and Its Relationship with Metastatic Tumor Formation
- (2011) D. Yao et al. MOLECULAR CANCER RESEARCH
- Mouse Snail Is a Target Gene for HIF
- (2011) D. Luo et al. MOLECULAR CANCER RESEARCH
- Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition
- (2011) Min-Zu Wu et al. MOLECULAR CELL
- Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context
- (2011) Jesús Espada et al. NUCLEIC ACIDS RESEARCH
- Nuclear Factor-κB–Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions
- (2011) Zhuo-Xin Cheng et al. PLoS One
- A Perspective on Cancer Cell Metastasis
- (2011) C. L. Chaffer et al. SCIENCE
- AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
- (2010) Zhijun Luo et al. Future Oncology
- Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial–mesenchymal transition in colorectal carcinoma cells
- (2010) Ignacio Mazón Peláez et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype
- (2010) Gianluca Storci et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-β-dependent mechanisms
- (2010) Bryan L. Copple LIVER INTERNATIONAL
- Mechanism of Hypoxia-Induced NF- B
- (2010) C. Culver et al. MOLECULAR AND CELLULAR BIOLOGY
- Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells
- (2010) Y Wang et al. ONCOGENE
- Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
- (2009) J Chen et al. BRITISH JOURNAL OF CANCER
- Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
- (2009) Zhizhong Li et al. CANCER CELL
- Immunohistochemical Detection of Changes in Tumor Hypoxia
- (2009) James Russell et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- HIF2α cooperates with RAS to promote lung tumorigenesis in mice
- (2009) William Y. Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- The basics of epithelial-mesenchymal transition
- (2009) Raghu Kalluri et al. JOURNAL OF CLINICAL INVESTIGATION
- Significance of Twist expression and its association with E-cadherin in esophageal squamous cell carcinoma
- (2009) Ken Sasaki et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells
- (2009) Kyoung-Ok Hong et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways
- (2008) T. T. Onder et al. CANCER RESEARCH
- Non-Smad pathways in TGF-β signaling
- (2008) Ying E Zhang CELL RESEARCH
- The actin cytoskeleton in cancer cell motility
- (2008) Michael F. Olson et al. CLINICAL & EXPERIMENTAL METASTASIS
- HIF-1α and HIF-2α have divergent roles in colon cancer
- (2008) Takaaki Imamura et al. INTERNATIONAL JOURNAL OF CANCER
- Overexpression of Intrinsic Hypoxia Markers HIF1α and CA-IX Predict for Local Recurrence in Stage T1-T2 Glottic Laryngeal Carcinoma Treated With Radiotherapy
- (2008) M.L. Schrijvers et al. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
- Cadherin switching
- (2008) M. J. Wheelock et al. JOURNAL OF CELL SCIENCE
- Direct regulation of TWIST by HIF-1α promotes metastasis
- (2008) Muh-Hwa Yang et al. NATURE CELL BIOLOGY
- Notch signaling mediates hypoxia-induced tumor cell migration and invasion
- (2008) C. Sahlgren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started