Article
Chemistry, Medicinal
Paola De Cicco, Giuseppe Ercolano, Gian Carlo Tenore, Angela Ianaro
Summary: This study investigated the effects of an extract from olive tree leaves (OLE) on metastatic melanoma, a highly aggressive and deadly form of skin cancer. The results showed that OLE inhibited melanoma cell proliferation, migration, invasion, and colonies formation both in vitro and in vivo. These effects were attributed to the targeting of mitogen-activated protein kinase and PI3K pathways. The findings suggest that OLE has the potential to be a new add-on therapy for the management of metastatic melanoma.
PHYTOTHERAPY RESEARCH
(2022)
Article
Environmental Sciences
Dapeng Wang, Huifen Xu, Lili Fan, Wenli Ruan, Qian Song, Heng Diao, Rui He, Ying Jin
Summary: Chronic arsenic exposure induces liver fibrosis in rats, which is associated with activation of hepatic stellate cells, excessive extracellular matrix secretion, and hepatocytes epithelial-mesenchymal transformation. Additionally, arsenite exposure causes hyperphosphorylation of EGFR/ERK signaling in liver tissue, suggesting its involvement in arsenic-induced liver fibrosis. Treatment with erlotinib, a specific phosphorylation inhibitor of EGFR, reduces hyperphosphorylation of EGFR/ERK signaling, suppresses hepatocytes EMT, and alleviates liver fibrogenesis in arsenite-exposed rats.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Kittipong Sanookpan, Nongyao Nonpanya, Boonchoo Sritularak, Pithi Chanvorachote
Summary: The study demonstrated that ovalitenone suppresses EMT via inhibition of the AKT/mTOR signaling pathway and has potential for inhibiting CSC phenotypes. These findings reveal the anti-metastasis potential of the compound and support the development of ovalitenone treatment for lung cancer therapy.
Article
Medicine, Research & Experimental
Tingjian Zu, Diana Wang, Shuyun Xu, Catherine A. A. Lee, Ellen Zhen, Charles H. Yoon, Phammela Abarzua, Shuangshuang Wang, Natasha Y. Frank, Xunwei Wu, Christine G. Lian, George F. Murphy
Summary: This study shows that ATF-3 acts as a suppressor in melanoma tumor progression, with overexpression inhibiting cell growth, migration, and invasion, ultimately halting tumor growth.
LABORATORY INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Sucharat Tungsukruthai, Boonchoo Sritularak, Pithi Chanvorachote
Summary: Lung cancer metastasis is a major cause of lung cancer-related deaths. This study investigated the potential of cycloartocarpin in inhibiting the metastasis of lung cancer cells. The results showed that non-toxic concentrations of cycloartocarpin effectively suppressed cell migration and attenuated anchorage-independent cell growth. This was accompanied by the inhibition of the EMT process through the suppression of the FAK/AKT signaling pathway.
Article
Medicine, Research & Experimental
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal-Egana, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Faergeman, Ole N. Jensen, Rasmus Siersbaek, Kumar Somyajit, Paolo Ceppi
Summary: This study found an inverse association between short-chain fatty acids and EMT in non-small cell lung cancer patients. In vitro experiments showed that propionate treatment enhanced the epithelial transcriptional program and reduced the EMT phenotype in lung cancer cell lines. Animal experiments also confirmed that propionate can reduce lung cancer metastasis and lymph node spread. Further mechanistic investigation revealed that propionate treatment caused chromatin remodeling through p300-mediated histone acetylation.
EMBO MOLECULAR MEDICINE
(2023)
Article
Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
Article
Food Science & Technology
Zhenyu Cao, Jianwu Ma, Xiaozhong Shen
Summary: Alpinetin has potential therapeutic effects on osteosarcoma through inhibiting cell proliferation, promoting apoptosis, and inhibiting cell metastasis by inactivating the PI3K/AKT and ERK signaling pathways.
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2022)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Ying Chen, Hui Xu, Pei Yu, Qing Wang, Shenggang Li, Fufu Ji, Chunwang Wu, Qing Lan
Summary: Previous studies have shown that high expression of IFI30 is associated with glioma and tumor grade. In this study, it was found that IFI30 promotes the epithelial-mesenchymal transition (EMT) process in glioma cells through the activation of the EGFR/AKT/GSK3 beta/beta-catenin pathway. Additionally, IFI30 regulates the chemoresistance of glioma cells to temozolomide by affecting the expression of the transcription factor Slug. These findings indicate that IFI30 may serve as a prognostic marker and a potential therapeutic target for temozolomide-resistant glioma.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Jieqing Zhou, Hong Jiang, Hongkun Jiang, Yan Fan, Jing Zhang, Xiaoxue Ma, Xuewei Yang, Yu Sun, Xing Zhao
Summary: ILEI facilitates renal interstitial fibrosis (RIF) via the Akt and ERK pathways and promotes renal tubular epithelial mesenchymal transition (EMT) by binding and activating leukemia inhibitory factor receptor (LIFR). Increased expression levels of ILEI and LIFR were observed in pediatric CKD patients with RIF.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Tzu-Ming Jao, Woei-Horng Fang, Shih-Ci Ciou, Sung-Liang Yu, Yu-Lin Hung, Wei-Ting Weng, Tsai-Yi Lin, Ming-Hong Tsai, Ya-Chien Yang
Summary: PCDH10 is identified as a tumor suppressor that induces cell cycle retardation and apoptosis in colorectal cancer cells, reverses epithelial-mesenchymal transition process, and inhibits stemness of CRC cells. PCDH10 inhibits AKT/GSK3 beta signaling pathway, reduces beta-catenin activity, and directly engages in negative regulation of EGFR/AKT/beta-catenin signaling pathway for tumor suppression.
Review
Biochemistry & Molecular Biology
Anastasios Goulioumis, Kostis Gyftopoulos
Summary: Epithelial-to-mesenchymal transition (EMT) is a molecular phenomenon that occurs in epithelial neoplasms, such as laryngeal carcinoma. EMT leads to the loss of epithelial traits and acquisition of mesenchymal traits by tumor cells, enhancing their migratory capacity. EMT is mediated by complex molecular pathways and involves various changes, including loss of adhesion, cytoskeleton remodeling, evasion of apoptosis and immune surveillance, upregulation of metalloproteinases, etc. Partial EMT models have been accepted to explain the cell plasticity associated with invasion and metastasis of tumors.
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)