Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR

Local Enrichment of Unsaturated Chains around the A2A Adenosine Receptor

(2019) Lewen Yang et al.   BIOCHEMISTRY

Elucidating ligand-bound structures of membrane proteins using solid-state NMR spectroscopy

(2019) Matthew R Elkins et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

(2018) Ichio Shimada et al.   NATURE REVIEWS DRUG DISCOVERY

Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots

(2017) Titiwat Sungkaworn et al.   NATURE

Validation of a Na + -shift binding assay for estimation of the intrinsic efficacy of ligands at the A 2A adenosine receptor

(2017) François Noël et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Ligand modulation of sidechain dynamics in a wild-type human GPCR

(2017) Lindsay D Clark et al.   eLife

GPCR Dynamics: Structures in Motion

(2016) Naomi R. Latorraca et al.   CHEMICAL REVIEWS

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Functional Roles of Fatty Acids and Their Effects on Human Health

(2015) Philip C. Calder   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Allosteric regulation of G protein–coupled receptor activity by phospholipids

(2015) Rosie Dawaliby et al.   Nature Chemical Biology

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy

(2014) Yutaka Kofuku et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Specific and Nonspecific Interactions in Ultraweak Protein–Protein Associations Revealed by Solvent Paramagnetic Relaxation Enhancements

(2014) Helle Johansson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modified lipid and protein dynamics in nanodiscs

(2012) Karsten Mörs et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region

(2012) Yutaka Kofuku et al.   Nature Communications

Uncovering the intimate relationship between lipids, cholesterol and GPCR activation

(2011) Joanne Oates et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

(2011) Mathieu Lafourcade et al.   NATURE NEUROSCIENCE

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

NMR Analyses of the Interaction between CCR5 and Its Ligand Using Functional Reconstitution of CCR5 in Lipid Bilayers

(2010) Chie Yoshiura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor

(2008) F. Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE