Organoids as a Powerful Model for Respiratory Diseases

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Long‐term expanding human airway organoids for disease modeling

(2019) Norman Sachs et al.   EMBO JOURNAL

Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction

(2019) Qiaozhen Liu et al.   NATURE GENETICS

Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids

(2019) M. Porotto et al.   mBio

Organoids by design

(2019) Takanori Takebe et al.   SCIENCE

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells

(2019) Alexandros Strikoudis et al.   Cell Reports

Engineered cell and tissue models of pulmonary fibrosis

(2018) Aswin Sundarakrishnan et al.   ADVANCED DRUG DELIVERY REVIEWS

Stem Cells in Pulmonary Disease and Regeneration

(2018) Rohan R. Nadkarni et al.   CHEST

Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

(2018) Beiyun Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic sequencing for surveillance of drug resistance in tuberculosis in highly endemic countries: a multi-country population-based surveillance study

(2018) Matteo Zignol et al.   LANCET INFECTIOUS DISEASES

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

(2018) Yanjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiated human airway organoids to assess infectivity of emerging influenza virus

(2018) Jie Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells

(2018) Ahmad N. Nabhan et al.   SCIENCE

Long-term Engraftment Promotes Differentiation of Alveolar Epithelial Cells from Human Embryonic Stem Cells Derived Lung Organoids

(2018) Yong Chen et al.   STEM CELLS AND DEVELOPMENT

Human organoid cultures: transformative new tools for human virus studies

(2018) Sasirekha Ramani et al.   Current Opinion in Virology

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures

(2018) Kenrie P Y Hui et al.   Lancet Respiratory Medicine

Use of 3D organoids and lung-on-a-chip methods to study lung development, regeneration and disease

(2018) Konstantinos Gkatzis et al.   EUROPEAN RESPIRATORY JOURNAL

Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung

(2018) Yusuke Tanaka et al.   EXPERIMENTAL CELL RESEARCH

Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis

(2018) Shin-Ichi Nureki et al.   JOURNAL OF CLINICAL INVESTIGATION

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

(2018) William J. Zacharias et al.   NATURE

Idiopathic Pulmonary Fibrosis

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation

(2018) John-Poul Ng-Blichfeldt et al.   EBioMedicine

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids

(2017) Yuki Yamamoto et al.   NATURE METHODS

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

(2017) Zhen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Experimental study of tuberculosis: From animal models to complex cell systems and organoids

(2017) Kaori L. Fonseca et al.   PLoS Pathogens

Animal Models for Tuberculosis in Translational and Precision Medicine

(2017) Lingjun Zhan et al.   Frontiers in Microbiology

Organoids as a model system for studying human lung development and disease

(2016) Rohan R. Nadkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hyaluronan and TLR4 promote surfactant-protein-C-positive alveolar progenitor cell renewal and prevent severe pulmonary fibrosis in mice

(2016) Jiurong Liang et al.   NATURE MEDICINE

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair

(2016) Jennifer Quantius et al.   PLoS Pathogens

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling

(2016) Dan C. Wilkinson et al.   Stem Cells Translational Medicine

The development and plasticity of alveolar type 1 cells

(2015) Jun Yang et al.   DEVELOPMENT

Modeling mouse and human development using organoid cultures

(2015) M. Huch et al.   DEVELOPMENT

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

(2015) Rajan Jain et al.   Nature Communications

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Alveolar progenitor and stem cells in lung development, renewal and cancer

(2014) Tushar J. Desai et al.   NATURE

p63+Krt5+ distal airway stem cells are essential for lung regeneration

(2014) Wei Zuo et al.   NATURE

Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

(2014) Barbara Treutlein et al.   NATURE

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro

(2014) Helena Morales Johansson et al.   PLoS One

Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells

(2014) Shimpei Gotoh et al.   Stem Cell Reports

Human iPS cell–derived alveolar epithelium repopulates lung extracellular matrix

(2013) Mahboobe Ghaedi et al.   JOURNAL OF CLINICAL INVESTIGATION

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Efficient generation of lung and airway epithelial cells from human pluripotent stem cells

(2013) Sarah X L Huang et al.   NATURE BIOTECHNOLOGY

Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells

(2012) Tyler A. Longmire et al.   Cell Stem Cell

Building and maintaining the epithelium of the lung

(2012) Craig R. Rackley et al.   JOURNAL OF CLINICAL INVESTIGATION

Airway Epithelial Progenitors Are Region Specific and Show Differential Responses to Bleomycin-Induced Lung Injury

(2012) Huaiyong Chen et al.   STEM CELLS

Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice

(2011) Harold A. Chapman et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional Analysis of Two Distinct Bronchiolar Progenitors during Lung Injury and Repair

(2010) Roxana M. Teisanu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary Disease

(2010) Jeffrey A. Whitsett et al.   Annual Review of Medicine

HTII-280, a Biomarker Specific to the Apical Plasma Membrane of Human Lung Alveolar Type II Cells

(2010) Robert F. Gonzalez et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Respiratory Syncytial Virus-Neutralizing Monoclonal Antibodies Motavizumab and Palivizumab Inhibit Fusion

(2010) K. Huang et al.   JOURNAL OF VIROLOGY

Evidence of an epithelial stem/progenitor cell hierarchy in the adult mouse lung

(2010) J. L. McQualter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Genetic Defects in Surfactant Protein A2 Are Associated with Pulmonary Fibrosis and Lung Cancer

(2008) Yongyu Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS