Experimental study of tuberculosis: From animal models to complex cell systems and organoids

Bioengineered 3D Models for Studying Human Cell–Tuberculosis Interactions

(2017) Sulayman Benmerzoug et al.   TRENDS IN MICROBIOLOGY

A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis

(2017) Magdalena K. Bielecka et al.   mBio

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

(2017) Liku B Tezera et al.   eLife

Organoids as a model system for studying human lung development and disease

(2016) Rohan R. Nadkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Advances in Zika Virus Research: Stem Cell Models, Challenges, and Opportunities

(2016) Guo-li Ming et al.   Cell Stem Cell

Isoniazid-induced control of Mycobacterium tuberculosis by primary human cells requires interleukin-1 receptor and tumor necrosis factor

(2016) Lívia H. Yamashiro et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth ofMycobacterium tuberculosis

(2016) Claire E. Dodd et al.   JOURNAL OF IMMUNOLOGY

Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques withMycobacterium tuberculosisInfection

(2016) Hannah P. Gideon et al.   JOURNAL OF IMMUNOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype

(2016) Clare M. Smith et al.   mBio

Pulmonary Tuberculosis in Humanized Mice Infected with HIV-1

(2016) Rebecca J. Nusbaum et al.   Scientific Reports

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

(2016) Vidhya R. Nair et al.   Cell Reports

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions

(2016) Christian Lienhardt et al.   PLOS MEDICINE

Experimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of Tuberculosis

(2016) Pierre Santucci et al.   Frontiers in Cellular and Infection Microbiology

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells

(2016) Satoshi Konishi et al.   Stem Cell Reports

The Zebrafish Breathes New Life into the Study of Tuberculosis

(2016) Henna Myllymäki et al.   Frontiers in Immunology

Tuberculosis

(2016) Madhukar Pai et al.   Nature Reviews Disease Primers

Animal models in tuberculosis research – where is the beef?

(2015) Henna Myllymäki et al.   Expert Opinion on Drug Discovery

Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool

(2015) Christopher L. Karp et al.   IMMUNOLOGICAL REVIEWS

Trans-species communication in theMycobacterium tuberculosis-infected macrophage

(2015) Shumin Tan et al.   IMMUNOLOGICAL REVIEWS

Immunology studies in non-human primate models of tuberculosis

(2015) JoAnne L. Flynn et al.   IMMUNOLOGICAL REVIEWS

Cellular therapy in Tuberculosis

(2015) Shreemanta K. Parida et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Alveolar Epithelial Cells in Mycobacterium tuberculosis Infection: Active Players or Innocent Bystanders?

(2015) Julia M. Scordo et al.   Journal of Innate Immunity

WHO's new End TB Strategy

(2015) Mukund Uplekar et al.   LANCET

The balance between protective and pathogenic immune responses in the TB-infected lung

(2015) Ian M Orme et al.   NATURE IMMUNOLOGY

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Protection and pathology in TB: learning from the zebrafish model

(2015) Annemarie H. Meijer   Seminars in Immunopathology

Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies

(2015) Igor Kramnik et al.   Seminars in Immunopathology

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis

(2015) Anca Dorhoi et al.   Seminars in Immunopathology

Characterization of Host and Microbial Determinants in Individuals with Latent Tuberculosis Infection Using a Human Granuloma Model

(2015) Evelyn Guirado et al.   mBio

Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model

(2015) Jie Zhao et al.   eLife

Persistence and Toxin Production by Clostridium difficile within Human Intestinal Organoids Result in Disruption of Epithelial Paracellular Barrier Function

(2014) Jhansi L. Leslie et al.   INFECTION AND IMMUNITY

Monkey Models of Tuberculosis: Lessons Learned

(2014) Juliet C. Peña et al.   INFECTION AND IMMUNITY

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Animal Models of Tuberculosis: Guinea Pigs

(2014) S. Clark et al.   Cold Spring Harbor Perspectives in Medicine

Mouse Model of Tuberculosis

(2014) A. M. Cooper   Cold Spring Harbor Perspectives in Medicine

Modeling Tuberculosis in Nonhuman Primates

(2014) C. A. Scanga et al.   Cold Spring Harbor Perspectives in Medicine

The lack of a big picture in tuberculosis: the clinical point of view, the problems of experimental modeling and immunomodulation. The factors we should consider when designing novel treatment strategies

(2014) Cristina Vilaplana et al.   Frontiers in Microbiology

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

Modeling Mycobacterium tuberculosis early granuloma formation in experimental human lung tissue

(2013) V. R. Parasa et al.   Disease Models & Mechanisms

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Human Granuloma In Vitro Model, for TB Dormancy and Resuscitation

(2013) Nidhi Kapoor et al.   PLoS One

A Humanized Mouse Model of Tuberculosis

(2013) Veronica E. Calderon et al.   PLoS One

CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria

(2013) F. Heuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prospects for Tuberculosis Elimination

(2012) Christopher Dye et al.   Annual Review of Public Health

Tuberculosis: cost of illness in Germany

(2012) Roland Diel et al.   EUROPEAN RESPIRATORY JOURNAL

Animal Welfare in Studies on Murine Tuberculosis: Assessing Progress over a 12-Year Period and the Need for Further Improvement

(2012) Nuno Henrique Franco et al.   PLoS One

Insights into tuberculosis from the zebrafish model

(2012) Russell D. Berg et al.   TRENDS IN MOLECULAR MEDICINE

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses

(2012) S. R. Finkbeiner et al.   mBio

How “Humane” Is Your Endpoint?—Refining the Science-Driven Approach for Termination of Animal Studies of Chronic Infection

(2012) Nuno H. Franco et al.   PLoS Pathogens

In vitro differentiation of human macrophages with enhanced antimycobacterial activity

(2011) Guillaume Vogt et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

(2011) Smriti Mehra et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Human Macrophage Responses to Clinical Isolates from the Mycobacterium tuberculosis Complex Discriminate between Ancient and Modern Lineages

(2011) Damien Portevin et al.   PLoS Pathogens

A Novel in vitro Human Macrophage Model to Study the Persistence of Mycobacterium tuberculosis Using Vitamin D3 and Retinoic Acid Activated THP-1 Macrophages

(2011) Jaymie L. Estrella et al.   Frontiers in Microbiology

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

Innate Immune Response to Mycobacterium tuberculosis Beijing and Other Genotypes

(2010) Chongzhen Wang et al.   PLoS One

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens