Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

(2020) Lijun Wang et al.   Nature Communications

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Stimulation of Piezo1 by mechanical signals promotes bone anabolism

(2019) Xuehua Li et al.   eLife

Skeletal cell YAP and TAZ combinatorially promote bone development

(2018) Christopher D. Kegelman et al.   FASEB JOURNAL

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RAP2 mediates mechanoresponses of the Hippo pathway

(2018) Zhipeng Meng et al.   NATURE

An atlas of genetic influences on osteoporosis in humans and mice

(2018) John A. Morris et al.   NATURE GENETICS

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Rare and low-frequency coding variants alter human adult height

(2017) Eirini Marouli et al.   NATURE

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanical forces direct stem cell behaviour in development and regeneration

(2017) Kyle H. Vining et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization

(2017) Adrienne E. Dubin et al.   NEURON

InducedGnasR201Hexpression from the endogenousGnaslocus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling

(2017) Sanjoy Kumar Khan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of PIEZO2 in Human Mechanosensation

(2016) Alexander T. Chesler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

(2016) Fuqin Fan et al.   Science Translational Medicine

Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

(2016) Charles D. Cox et al.   Nature Communications

Localized force application reveals mechanically sensitive domains of Piezo1

(2016) Jason Wu et al.   Nature Communications

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Chemical activation of the mechanotransduction channel Piezo1

(2015) Ruhma Syeda et al.   eLife

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

Regulation of YAP by Mechanical Strain through Jnk and Hippo Signaling

(2014) Veronica A. Codelia et al.   CURRENT BIOLOGY

Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin

(2014) Rebekah S. Decker et al.   DEVELOPMENTAL BIOLOGY

Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

(2014) Alyson Morse et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Piezo2 is required for Merkel-cell mechanotransduction

(2014) Seung-Hyun Woo et al.   NATURE

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse

(2014) J. Michael Gee et al.   NEURON

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin and cadherin signaling in bone: role and potential therapeutic targets

(2014) Pierre J. Marie et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Human PIEZO1: Removing Inactivation

(2013) Chilman Bae et al.   BIOPHYSICAL JOURNAL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Mechanosensitive ion channels

(2012) Boris Martinac   Channels

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

(2012) Brian J. McHugh et al.   PLoS One

Fabrication of Hydrogels with Steep Stiffness Gradients for Studying Cell Mechanical Response

(2012) Raimon Sunyer et al.   PLoS One

Adhesive and mechanical regulation of mesenchymal stem cell differentiation in human bone marrow and periosteum-derived progenitor cells

(2012) J. Eyckmans et al.   Biology Open

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

Pannexin 3 functions as an ER Ca2+channel, hemichannel, and gap junction to promote osteoblast differentiation

(2011) Masaki Ishikawa et al.   JOURNAL OF CELL BIOLOGY

RNAscope

(2011) Fay Wang et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Mechanobiology of embryonic skeletal development: Insights from animal models

(2010) Niamh C. Nowlan et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells

(2010) Daniel J. Kelly et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Mechanotransduction in bone repair and regeneration

(2010) Chenyu Huang et al.   FASEB JOURNAL

“Mesenchymal” Stem Cells in Human Bone Marrow (Skeletal Stem Cells): A Critical Discussion of Their Nature, Identity, and Significance in Incurable Skeletal Disease

(2010) Paolo Bianco et al.   HUMAN GENE THERAPY

Calcium-mediated Stress Kinase Activation by DMP1 Promotes Osteoblast Differentiation

(2010) Asha Eapen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantifying fluid shear stress in a rocking culture dish

(2010) Xiaozhou Zhou et al.   JOURNAL OF BIOMECHANICS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Interaction of calcineurin with substrates and targeting proteins

(2010) Huiming Li et al.   TRENDS IN CELL BIOLOGY

Developing bones are differentially affected by compromised skeletal muscle formation

(2009) Niamh C. Nowlan et al.   BONE

Role of serum P1NP measurement for monitoring treatment response in osteoporosis

(2008) Michael Samoszuk et al.   Biomarkers in Medicine

Effect of botulinum toxin A-induced paralysis and exercise training on mechanosensing and signalling gene expression in juvenile rat gastrocnemius muscle

(2008) Martina Velders et al.   EXPERIMENTAL PHYSIOLOGY

Involvement of stretch-activated ion channels in strain-regulated glycosaminoglycan synthesis in mesenchymal stem cell-seeded 3D scaffolds

(2008) Louise A. McMahon et al.   JOURNAL OF BIOMECHANICS

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY