Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Stem Cell Therapies in Clinical Trials: Progress and Challenges

(2015) Alan Trounson et al.   Cell Stem Cell

Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers

(2015) Willscott E. Naugler et al.   GASTROENTEROLOGY

Structural basis for Mob1-dependent activation of the core Mst–Lats kinase cascade in Hippo signaling

(2015) Lisheng Ni et al.   GENES & DEVELOPMENT

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

(2015) Inge Mannaerts et al.   JOURNAL OF HEPATOLOGY

Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity

(2015) Jing Geng et al.   NATURE IMMUNOLOGY

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

(2015) Y. Zhang et al.   SCIENCE

Drug-induced regeneration in adult mice

(2015) Yong Zhang et al.   Science Translational Medicine

A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice

(2015) Ying Tian et al.   Science Translational Medicine

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

(2015) Brian D. Polizzotti et al.   Science Translational Medicine

Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury

(2015) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of mammalian Ste20 (Mst) kinases

(2015) Sonali J. Rawat et al.   TRENDS IN BIOCHEMICAL SCIENCES

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis

(2015) Hongtan Wu et al.   Nature Communications

A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer

(2014) Shi Jiao et al.   CANCER CELL

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Wound repair and regeneration: Mechanisms, signaling, and translation

(2014) S. A. Eming et al.   Science Translational Medicine

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5

(2013) Lisheng Ni et al.   STRUCTURE

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

A Review of Acetaminophen Poisoning

(2012) Michael J. Hodgman et al.   CRITICAL CARE CLINICS

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes

(2012) Fan Mou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein kinases of the Hippo pathway: Regulation and substrates

(2012) Joseph Avruch et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Yes-associated protein is involved in proliferation and differentiation during postnatal liver development

(2011) Seth Septer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor

(2009) Ruchi Anand et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

(2008) Qi Zeng et al.   CANCER CELL

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY