Biochemical Signals Mediate the Crosstalk between Cartilage and Bone in Osteoarthritis

Microcracks in subchondral bone plate is linked to less cartilage damage

(2019) M. Zarka et al.   BONE

Artesunate, an Anti-Malaria Agent, Attenuates Experimental Osteoarthritis by Inhibiting Bone Resorption and CD31hiEmcnhi Vessel Formation in Subchondral Bone

(2019) Yicheng Li et al.   Frontiers in Pharmacology

SDF-1/CXCR4 axis coordinates crosstalk between subchondral bone and articular cartilage in osteoarthritis pathogenesis

(2019) Han-Jun Qin et al.   BONE

Recent advances in osteoclast biology

(2018) Takehito Ono et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone

(2018) Baochao Ji et al.   Scientific Reports

Magnoflorine with hyaluronic acid gel promotes subchondral bone regeneration and attenuates cartilage degeneration in early osteoarthritis

(2018) Zhe Cai et al.   BONE

The Role of Wnt Pathway in the Pathogenesis of OA and Its Potential Therapeutic Implications in the Field of Regenerative Medicine

(2018) Maria De Santis et al.   Biomed Research International

Effects of loading on chondrocyte hypoxia, HIF-1α and VEGF in the mandibular condylar cartilage of young rats

(2017) J. Yu et al.   Orthodontics & Craniofacial Research

Yougui Pills Attenuate Cartilage Degeneration via Activation of TGF-β/Smad Signaling in Chondrocyte of Osteoarthritic Mouse Model

(2017) Lei Zhang et al.   Frontiers in Pharmacology

Runx2 Controls Bone Resorption through the Down-Regulation of the Wnt Pathway in Osteoblasts

(2016) Coline Haxaire et al.   AMERICAN JOURNAL OF PATHOLOGY

New developments in osteoarthritis and cartilage biology

(2016) Blandine Poulet et al.   CURRENT OPINION IN PHARMACOLOGY

Is there crosstalk between subchondral bone, cartilage, and meniscus in the pathogenesis of osteoarthritis?

(2016) O. Şahap Atik   Eklem Hastaliklari ve Cerrahisi-Joint Diseases and Related Surgery

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis

(2016) H. Iijima et al.   OSTEOARTHRITIS AND CARTILAGE

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

High Density Infill in Cracks and Protrusions from the Articular Calcified Cartilage in Osteoarthritis in Standardbred Horse Carpal Bones

(2015) Sheila Laverty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cartilage degeneration and excessive subchondral bone formation in spontaneous osteoarthritis involves altered TGF-β signaling

(2015) Weiwei Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Transforming growth factor-β1 induces type II collagen and aggrecan expression via activation of extracellular signal-regulated kinase 1/2 and Smad2/3 signaling pathways

(2015) YANHUI ZHU et al.   Molecular Medicine Reports

Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis

(2015) Martijn H. van den Bosch et al.   RHEUMATOLOGY

Chondrocytes-Specific Expression of Osteoprotegerin Modulates Osteoclast Formation in Metaphyseal Bone

(2015) Baoli Wang et al.   Scientific Reports

Predicting and validating the pathway of Wnt3a-driven suppression of osteoclastogenesis

(2014) Kazunori Hamamura et al.   CELLULAR SIGNALLING

Signaling Pathways in Cartilage Repair

(2014) Erminia Mariani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats

(2013) Songsong Zhu et al.   BONE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Diagnosis and Treatment of Osteoarthritis

(2013) Rafaelani L. Taruc-Uy et al.   PRIMARY CARE

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation

(2013) Jia Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

(2013) Guangyi Li et al.   ARTHRITIS RESEARCH & THERAPY

Analysis of the Mineral Composition of the Human Calcified Cartilage Zone

(2012) Ying Zhang et al.   International Journal of Medical Sciences

Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis

(2012) I. PRASADAM et al.   JOURNAL OF RHEUMATOLOGY

Osteoarthritis induction leads to early and temporal subchondral plate porosity in the tibial plateau of mice: An in vivo microfocal computed tomography study

(2011) Sander M. Botter et al.   ARTHRITIS AND RHEUMATISM

Osteoimmunology: cytokines and the skeletal system

(2011) Seoung-Hoon Lee et al.   BMB Reports

The expression of RANKL and OPG in the various grades of osteoarthritic cartilage

(2011) Angus R. Upton et al.   RHEUMATOLOGY INTERNATIONAL

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

Proliferative re-modeling of the spatial organization of human superficial chondrocytes distant to focal early osteoarthritis (OA)

(2010) Bernd Rolauffs et al.   ARTHRITIS AND RHEUMATISM

Inorganic Phosphate Induces Mammalian Growth Plate Chondrocyte Apoptosis in a Mitochondrial Pathway Involving Nitric Oxide and JNK MAP Kinase

(2010) M. Zhong et al.   CALCIFIED TISSUE INTERNATIONAL

The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study

(2010) Stephanie K Tanamas et al.   ARTHRITIS RESEARCH & THERAPY

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2

(2009) Indira Prasadam et al.   BONE

Chondrocyte survival in articular cartilage

(2009) A. K. Amin et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Osteochondral angiogenesis and increased protease inhibitor expression in OA

(2009) R.E. Fransès et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Should subchondral bone turnover be targeted when treating osteoarthritis?

(2008) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis

(2007) S.M. Botter et al.   OSTEOARTHRITIS AND CARTILAGE