Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis

Induction of Canonical Wnt Signaling by Synovial Overexpression of Selected Wnts Leads to Protease Activity and Early Osteoarthritis-Like Cartilage Damage

(2015) Martijn H. van den Bosch et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of WNT16 in the Regulation of Periosteal Bone Formation in Female Mice

(2015) Jon E. Wergedal et al.   ENDOCRINOLOGY

Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

(2015) Dennis F. G. Remst et al.   RHEUMATOLOGY

Wnt CoreceptorLrp5Is a Driver of Idiopathic Pulmonary Fibrosis

(2014) Anna P. Lam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8

(2014) Martijn H. van den Bosch et al.   CELLULAR SIGNALLING

Role of Wnt Signaling in Tissue Fibrosis, Lessons from Skeletal Muscle and Kidney

(2014) P. Cisternas et al.   CURRENT MOLECULAR MEDICINE

Mest Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting the Wnt/β-Catenin Signaling Pathway

(2014) Wenting Li et al.   Gut and Liver

miR-92a regulates TGF-β1-induced WISP1 expression in pulmonary fibrosis

(2014) Barbara Berschneider et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genes Involved in the Osteoarthritis Process Identified through Genome Wide Expression Analysis in Articular Cartilage; the RAAK Study

(2014) Yolande F. M. Ramos et al.   PLoS One

Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-catenin signaling

(2014) Perumal MadanKumar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes

(2014) Carole Bougault et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Blockade of canonical Wnt signalling ameliorates experimental dermal fibrosis

(2013) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion

(2013) Ju-Fang Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Wnt-Induced Secreted Protein 1/CCN4 in Liver Fibrosis Both in vitro and in vivo

(2013) Yi-cheng Jian et al.   Clinical Laboratory

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Epiphyseal Cartilage Development through β-Catenin-dependent and -independent Pathways

(2013) Xianrong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klotho to Treat Kidney Fibrosis

(2013) M. D. Sanchez-Nino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways

(2013) Marjolein E. Blaauboer et al.   MATRIX BIOLOGY

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

(2013) Chun-Han Hou et al.   ARTHRITIS RESEARCH & THERAPY

Dkk-1 expression in chondrocytes inhibits experimental osteoarthritic cartilage destruction in mice

(2012) Hwanhee Oh et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The Tangled Web of Non-Canonical Wnt Signalling in Neural Migration

(2012) Charlotte E.J. Clark et al.   NEUROSIGNALS

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis

(2012) L. Lodewyckx et al.   RHEUMATOLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

(2012) Hou-Feng Zheng et al.   PLoS Genetics

Age-dependent alteration of TGF-β signalling in osteoarthritis

(2011) Peter M. van der Kraan et al.   CELL AND TISSUE RESEARCH

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Blockade of the Wnt/β-Catenin Pathway Attenuates Bleomycin-Induced Pulmonary Fibrosis

(2011) Tae Hyung Kim et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases

(2010) Ryohichi Sugimura et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

(2010) Mitsuaki Ono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transient Activation of Wnt/β-Catenin Signaling Induces Abnormal Growth Plate Closure and Articular Cartilage Thickening in Postnatal Mice

(2009) Takahito Yuasa et al.   AMERICAN JOURNAL OF PATHOLOGY

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth

(2009) K. L. Bennewith et al.   CANCER RESEARCH

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

(2009) Kamana Misra et al.   DEVELOPMENTAL BIOLOGY

WNT1-inducible signaling protein–1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis

(2009) Melanie Königshoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Wnt/β-Catenin Pathway Interacts Differentially with PTHrP Signaling to Control Chondrocyte Hypertrophy and Final Maturation

(2009) Xizhi Guo et al.   PLoS One

The Effects of Wnt Inhibitors on the Chondrogenesis of Human Mesenchymal Stem Cells

(2009) Gun-Il Im et al.   TISSUE ENGINEERING PART A

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling

(2008) X. Guo et al.   GENES & DEVELOPMENT

Smad3 activates the Sox9-dependent transcription on chromatin

(2008) Takayuki Furumatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

In vivo role of lipid adducts on Wingless

(2008) X. Franch-Marro et al.   JOURNAL OF CELL SCIENCE

TGF-β1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function

(2008) Colette A. Inkson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

Inflammation induction of Dickkopf-1 mediates chondrocyte apoptosis in osteoarthritic joint

(2008) L.-H. Weng et al.   OSTEOARTHRITIS AND CARTILAGE

The Contribution of Genes to Osteoarthritis

(2008) Ana M. Valdes et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Translating insights from development into regenerative medicine: The function of Wnts in bone biology

(2008) P. Leucht et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology

Cell death in osteoarthritis

(2008) Marcello Del Carlo et al.   Current Rheumatology Reports