Linking skeletal muscle aging with osteoporosis by lamin A/C deficiency

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations

(2019) Suet Nee Chen et al.   CIRCULATION RESEARCH

Cellular senescence in bone

(2019) Joshua N. Farr et al.   BONE

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

Musculoskeletal senescence: a moving target ready to be eliminated

(2018) Marjolein P Baar et al.   CURRENT OPINION IN PHARMACOLOGY

Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis

(2018) Sundeep Khosla et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lamins and bone disorders: current understanding and perspectives

(2018) Chiara Gargiuli et al.   Oncotarget

Sarcoglycan Alpha Mitigates Neuromuscular Junction Decline in Aged Mice by Stabilizing LRP4

(2018) Kai Zhao et al.   JOURNAL OF NEUROSCIENCE

Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A2AR signaling

(2017) Lei Xiong et al.   JOURNAL OF CELL BIOLOGY

Lamins in the nuclear interior − life outside the lamina

(2017) Nana Naetar et al.   JOURNAL OF CELL SCIENCE

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

(2017) Coralie Cazin et al.   Jove-Journal of Visualized Experiments

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

(2016) Camilla Evangelisti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Osteoporosis and sarcopenia

(2016) Jean-Yves Reginster et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Diagnosis and Management of Distal Clavicle Osteolysis

(2016) Steven F. DeFroda et al.   ORTHOPEDICS

Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response

(2016) Lei Xiong et al.   EBioMedicine

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice

(2015) Laura Pelosi et al.   HUMAN MOLECULAR GENETICS

Lrp4 in osteoblasts suppresses bone formation and promotes osteoclastogenesis and bone resorption

(2015) Lei Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

(2015) Tom Sieprath et al.   Nucleus

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

(2015) Tom Sieprath et al.   Nucleus

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training

(2011) Frode Norheim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Osteoblasts from a mandibuloacral dysplasia patient induce human blood precursors to differentiate into active osteoclasts

(2011) Sofia Avnet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans

(2011) Anna Rufo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Bone is functionally impaired in dystrophic mice but less so than skeletal muscle

(2011) Susan A. Novotny et al.   NEUROMUSCULAR DISORDERS

Decreased Bone Formation and Osteopenia in Lamin A/C-Deficient Mice

(2011) Wei Li et al.   PLoS One

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

De novoLMNAmutations cause a new form of congenital muscular dystrophy

(2008) Susana Quijano-Roy et al.   ANNALS OF NEUROLOGY

The dual role of IL-6-type cytokines on bone remodeling and bone tumors

(2008) Frédéric Blanchard et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727Phosphorylation of Signal Transducer and Activator of Transcription 3

(2008) Laurence Duplomb et al.   ENDOCRINOLOGY

Osteoporosis: An Age-Related and Gender-Specific Disease – A Mini-Review

(2008) Peter Pietschmann et al.   GERONTOLOGY

Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways

(2008) Fumio Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Lamin A/C Knockdown on Osteoblast Differentiation and Function

(2008) Rahima Akter et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

(2008) Darren J. Baker et al.   NATURE CELL BIOLOGY