Review
Biochemistry & Molecular Biology
Takuma Matsubara, Kazuma Yasuda, Kana Mizuta, Hiroka Kawaue, Shoichiro Kokabu
Summary: Osteoclasts and osteoblasts are the key cells regulating bone homeostasis. Imbalance between increased bone resorption by osteoclasts and decreased bone formation by osteoblasts leads to osteoporosis and other metabolic bone diseases. Src has been identified as an essential factor for bone resorption and a suppressor of bone formation. However, developing effective therapies targeting Src is challenging due to its widespread expression and involvement in various biological processes. Understanding the molecular mechanism of Src in bone is crucial for the treatment of bone metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Summary: Neuropilin 2 (NRP2) plays a role in bone homeostasis by regulating osteoblasts and osteoclasts. The expression of NRP2 in osteoblasts is induced by 1,25-dihydroxyvitamin D-3. Deletion of NRP2 in osteoblasts results in reduced bone mass, while deletion in osteoclasts does not have a bone phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Andrea Alford, Chris Stephan, Kenneth M. Kozloff, Kurt D. Hankenson
Summary: The trimeric thrombospondin homologs TSP1 and TSP2 play distinct roles in bone physiology, affecting periosteal and endosteal activities, respectively. The absence of both TSP1 and TSP2 results in a unique, sex-specific bone phenotype not observed in single knockouts.
Review
Pharmacology & Pharmacy
Shenglei Yang, Yuying Sun, Leonid Kapilevich, Xin'an Zhang, Yue Huang
Summary: Osteoporosis is a common skeletal disorder that primarily affects the elderly and postmenopausal women. Drug therapy is currently used as the main treatment, but long-term use can lead to drug resistance and side effects. Therefore, researchers are exploring natural plant compounds as an alternative. Curcumin, a natural phenolic compound, has shown potential as a candidate for treating osteoporosis due to its various pharmacological and biological activities. This review summarizes the mechanisms and therapeutic applications of curcumin in preventing and mitigating osteoporosis, providing valuable references for further research and development of curcumin.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Chemistry, Medicinal
Sophia Ogechi Ekeuku, Kok-Lun Pang, Kok-Yong Chih
Summary: Caffeic acid, a metabolite of hydroxycinnamate and phenylpropanoid, acts as an antioxidant to reduce osteoclastogenesis and bone resorption. However, in some cases, it may have no effect on bone resorption or even impair bone mechanical properties in normal rats.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biology
Lisha Li, Jing Zhou, Yingping Xu, Zengshu Huang, Na Zhang, Xuemin Qiu, Ling Wang
Summary: Inflammatory factors affect osteoblast and osteoclast activity in osteoporosis, and estrogen plays a role in bone metabolism through CCR6 signaling pathways. The study showed that CCR6 deletion reduced osteoblast activity and mineralization, while also influencing the expression of Osterix and RANKL, potentially regulating bone metabolism.
Review
Physiology
Xuejie Yi, Guangxuan Hu, Yang Yang, Jing Li, Junjie Jin, Bo Chang
Summary: This article reviews the distribution and function of MOTS-c in tissues, discusses the latest research developments in the regulation of osteoblasts and osteoclasts, and proposes potential molecular mechanisms for the effect of exercise on bone metabolism regulation.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Chenyu Zhu, Shiwei Shen, Shihua Zhang, Mei Huang, Lan Zhang, Xi Chen
Summary: Bone homeostasis is regulated by autophagy, which plays a critical role in the differentiation, apoptosis, and survival of bone cells. Oxidative stress induces autophagy as a protective response against cell damage. Understanding how autophagy regulates bone formation and bone resorption provides insights for potential therapeutic targets in osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Viviane A. Klemmer, Nupur Khera, Barbara M. Siegenthaler, Indranil Bhattacharya, Franz E. Weber, Chafik Ghayor
Summary: The human skeleton is a dynamic and highly organized organ system. N-Vinyl-2-pyrrolidone (NVP) enhances the effects of BMP2 on osteoblast and osteoclast differentiation, promoting bone regeneration. NVP may prove useful in situations requiring high rates of bone regeneration and in managing bone diseases associated with excessive bone resorption like osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Antonia Sophocleous, Michael Yiallourides, Feier Zeng, Pantelis Pantelas, Eleni Stylianou, Boya Li, Giovana Carrasco, Aymen I. Idris
Summary: Research on the modulation of CB1 and CB2 receptors on bone metabolism has shown that the results are confounded by the heterogeneity of models and the low number of studies.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Michelle Anna Maria Vis, Bregje Wilhelmina Maria de Wildt, Keita Ito, Sandra Hofmann
Summary: Culture medium exchange is necessary for nutrient supply and waste product accumulation prevention, but it leads to the loss of valuable factors produced by cells. Dialysis culture approach can provide a solution by exchanging low molecular weight molecules while maintaining high molecular weight components. This study developed a simple dialysis culture system and found increased activity in bone remodeling cells compared to the standard culture method, indicating the potential of this system in creating a more efficient microenvironment for cell interactions.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Immunology
Petra Henning, Sofia Moverare-Skrtic, Anna Westerlund, Pedro Paulo Chaves de Souza, Thais Floriano-Marcelino, Karin H. Nilsson, Maha El Shahawy, Claes Ohlsson, Ulf H. Lerner
Summary: The study found that OSM is a robust stimulator of Wnt16 mRNA in calvarial osteoblasts. OSM-induced Wnt16 expression is dependent on gp130, OSM receptor, and the SHC1/STAT3 pathway. Wnt16 expression is significantly lower in bone marrow cells compared to calvarial osteoblasts.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Shenglong Li, Wei Wang
Summary: Bone is a common site for metastasis, providing a favorable environment for the growth of tumor cells. Bone metastasis is a common complication in cancer patients, with EVs potentially playing a role in the pathological exchange between tumors and the bone microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Kok-Yong Chin, Ben Nett Ng, Muhd Khairik Imran Rostam, Nur Farah Dhaniyah Muhammad Fadzil, Vaishnavi Raman, Farzana Mohamed Yunus, Syed Alhafiz Syed Hashim, Sophia Ogechi Ekeuku
Summary: This review provides an overview of osteoporosis, including its biology, epidemiology, and clinical aspects, serving as an updated reference for readers to understand the basics of the disease and take preventive and management actions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Yonggang Ma, Di Ran, Xueni Shi, Hongyan Zhao, Zongping Liu
Summary: Cadmium is a widespread environmental contaminant that causes severe bone metabolism disease and dental issues. It affects bone cell and teeth development, leading to oxidative stress and DNA damage, ultimately resulting in cell apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Francesca Rossi, Giovanna Picone, Concettina Cappadone, Andrea Sorrentino, Marta Columbaro, Giovanna Farruggia, Emilio Catelli, Giorgia Sciutto, Silvia Prati, Robert Oliete, Alice Pasini, Eva Pereiro, Stefano Iotti, Emil Malucelli
Summary: Osteosarcoma (OS), the most common primary malignant bone tumor, is associated with osteogenic differentiation dysfunctions. In this study, conventional and X-ray synchrotron-based techniques were used to characterize mineral depositions in a human OS cell line (SaOS-2) exposed to osteogenic cocktail. The results showed that a partial restoration of physiological biomineralization occurred at 10 days after treatment, along with a mitochondria-driven mechanism for calcium transportation in the cells. Interestingly, mitochondria morphology changed during differentiation, indicating a metabolic reprogramming of OS cells possibly linked to increased glycolysis contribution to energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Nicolo Bozzini, Sofia Avnet, Nicola Baldini, Margherita Cortini
Summary: Epigenetic changes, which are heritable modifications not affecting DNA sequence directly, are crucial for the survival and proliferation of cancer cells, as they can differ significantly from healthy cells. Recently, sphingolipids have been identified as novel modulators of epigenetic changes in cancer, with ceramide and sphingosine 1-phosphate inducing various epigenetic modifications linked to cancer growth. Moreover, acellular factors in the tumor microenvironment, such as hypoxia and acidosis, play a crucial role in promoting aggressiveness through epigenetic modifications. This review focuses on the interaction between sphingolipids, cancer, epigenetic changes, and the chemical tumor microenvironment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nadia Bertola, Silvia Bruno, Cristina Capanni, Marta Columbaro, Andrea Nicola Mazzarello, Fabio Corsolini, Stefano Regis, Paolo Degan, Enrico Cappelli, Silvia Ravera
Summary: Fanconi anemia is a rare genetic disorder characterized by bone marrow failure and aplastic anemia. Recent studies have shown that FA cells also exhibit mitochondrial metabolism defects, which lead to intracellular lipid accumulation and oxidative damage. However, the molecular mechanisms underlying these metabolic alterations are still unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Vito Antonio Baldassarro, Francesca Perut, Maura Cescatti, Valentina Pinto, Nicola Fazio, Giuseppe Alastra, Valentina Parziale, Alessandra Bassotti, Mercedes Fernandez, Luciana Giardino, Nicola Baldini, Laura Calza
Summary: This study aims to characterize the individual variability of adipose tissue-derived mesenchymal stromal cells (adMSCs) secretome for potential therapeutic applications in neurology. The results showed significant individual variability in the secretion of PDGF-AA, PDGF-AB/BB, VEGF-A, and BDNF. The high BDNF-containing adMSCs medium demonstrated neuroprotective effects on neurons under oxygen-glucose deprivation conditions and promoted oligodendrocyte differentiation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Daniel Segelcke, Jan Linnemann, Bruno Pradier, Daniel Kronenberg, Richard Stange, S. Helene Richter, Dennis Goerlich, Nicola Baldini, Gemma Di Pompo, Waldiceu A. Verri Jr, Sofia Avnet, Esther M. Pogatzki-Zahn
Summary: Bone metastases are a common complication in advanced cancer patients, causing severe pain and reducing their quality of life. This study aimed to identify the pain phenotypes of cancer-induced bone pain (CIBP) in rats. CIBP in the splint bone caused mechanical hypersensitivity, resting pain, and antalgic gait in both sexes. The progression of tumor growth led to the establishment of the CIBP phenotype, which appeared earlier in male rats and affected social behaviors in both sexes.
Article
Oncology
Margherita Cortini, Francesca Macchi, Francesca Reggiani, Emanuele Vitale, Maria Veronica Lipreri, Francesca Perut, Alessia Ciarrocchi, Nicola Baldini, Sofia Avnet
Summary: The pathogenesis of osteosarcoma relies on complex interactions between cancer cells and extracellular matrix (ECM) proteins. Understanding these interactions and ECM composition is important for predicting cancer response to chemotherapy and identifying alternative therapeutic targets. This study aims to generate a 3D model that mimics the tumor microenvironment and investigate the role of ECM deposition in chemotherapy response. The findings suggest that targeting ECM proteins may improve outcomes for chemoresistant tumors.
Article
Oncology
Isabella Giacomini, Margherita Cortini, Mattia Tinazzi, Nicola Baldini, Veronica Cocetta, Eugenio Ragazzi, Sofia Avnet, Monica Montopoli
Summary: Osteosarcoma, the most common bone tumor in children and young adults, is also the second most fatal cancer. Despite the clinical benefit of chemotherapy, patients with osteosarcoma still face a poor prognosis due to drug resistance and frequent growth and metastasis of the disease. This study reveals a different mitochondrial phenotype in doxorubicin-resistant cancer cells and suggests targeting the altered pathway to reverse drug resistance. These findings contribute to understanding mitochondrial metabolism changes and developing strategies to overcome doxorubicin resistance in osteosarcoma.
Article
Cell Biology
Ramona Hartinger, Eva-Maria Lederer, Elisa Schena, Giovanna Lattanzi, Karima Djabali
Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that causes premature aging symptoms. Baricitinib and Bar + FTI treatments have been found to improve adipogenesis and lipid droplet formation in HGPS patients. The study also suggests that combined treatment with Bar and FTI may be more effective in ameliorating HGPS pathologies compared to lonafarnib treatment alone.
Article
Cell Biology
Clement Crochemore, Claudia Chica, Paolo Garagnani, Giovanna Lattanzi, Steve Horvath, Alain Sarasin, Claudio Franceschi, Maria Giulia Bacalini, Miria Ricchetti
Summary: Cockayne syndrome (CS) and UV-sensitive syndrome (UVSS) are rare genetic disorders caused by mutation of the DNA repair and multifunctional CSA or CSB protein. CS displays a progeroid and neurodegenerative phenotype, and differential analysis of DNA methylation (DNAm) revealed a CS-specific epigenomic signature enriched in developmental transcription factors, ion/neurotransmitter membrane transporters and synaptic neuro-developmental genes. CS also exhibited epigenetic hallmarks of accelerated ageing, including hypomethylation of Alu sequences and increased biological age compared to healthy and UVSS cells.
Article
Engineering, Biomedical
Maria Veronica Lipreri, Gemma Di Pompo, Elisa Boanini, Gabriela Graziani, Enrico Sassoni, Nicola Baldini, Sofia Avnet
Summary: Age-related musculoskeletal disorders, including osteoporosis, are common and have long-term morbidity, which greatly affects the sustainability of the healthcare system. Therefore, there is a need to develop reliable preclinical models and drug screening methods to test novel drugs without in vivo assays. This study describes a high throughput microfluidic platform for large-scale preclinical evaluation of drug efficacy in bone tissue. The platform utilizes an osteomimetic matrix, perfusion, and mechanical cues to culture osteocytes in a three-dimensional environment.
Article
Chemistry, Multidisciplinary
Tiziana Fischetti, Giorgia Borciani, Sofia Avnet, Katia Rubini, Nicola Baldini, Gabriela Graziani, Elisa Boanini
Summary: Reproducing a model of the bone microenvironment in vitro is currently needed. In vitro three-dimensional (3D) bone models, obtained through 3D bioprinting using hydroxyapatite nanoparticles, have advantages of high-throughput screening, low costs, and high reproducibility. These models can benefit preclinical in vitro screening, drug discovery, and pathophysiology studies. The use of hydroxyapatite nanoparticles derived from bone mineral as a component in the 3D bioprinting allows for control of scaffold characteristics and cell behavior. The findings show that the nanoparticles can be embedded in the inks without compromising cell viability, and different particle characteristics can significantly affect the behavior of the bioprinted constructs.
Review
Oncology
Enrico Lucarelli, Alessandro De Vita, Chiara Bellotti, Tommaso Frisoni, Silvia Vanni, Ania Naila Guerrieri, Micaela Pannella, Laura Mercatali, Marco Gambarotti, Serena Duchi, Giacomo Miserocchi, Margherita Maioli, Chiara Liverani, Toni Ibrahim
Summary: Myxofibrosarcoma (MFS) is a common malignant soft tissue sarcoma that mainly affects the extremities of patients after the age of 50. Surgical resection is the main treatment, but difficulties in distinguishing tumor boundaries can lead to residual tumor cells and recurrence. New therapeutic approaches are needed, especially for patients with multiple recurrences. In vitro and in vivo models are helpful in understanding the disease and testing new treatments.
Article
Cell Biology
Elisa Schena, Elisabetta Mattioli, Chiara Peres, Laura Zanotti, Paolo Morselli, Patricia Iozzo, Maria Angela Guzzardi, Chiara Bernardini, Monica Forni, Salvatore Nesci, Massimiliano Caprio, Carolina Cecchetti, Uberto Pagotto, Elena Gabusi, Luca Cattini, Gina Lisignoli, William Blalock, Alessandra Gambineri, Giovanna Lattanzi
Summary: This study identifies changes in MR and its interaction with lamin A in FPLD2, and demonstrates that the MR antagonist spironolactone can improve adipocyte differentiation and brown adipose tissue activity in FPLD2 patients.
Article
Biochemistry & Molecular Biology
Stefania Pagani, Manuela Salerno, Giuseppe Filardo, Janis Locs, Gerjo J. V. M. van Osch, Jana Vecstaudza, Laura Dolcini, Veronica Borsari, Milena Fini, Gianluca Giavaresi, Marta Columbaro
Summary: The study aimed to evaluate the in vitro osteogenic potential of a collagen/collagen-magnesium-hydroxyapatite (Col/Col-Mg-HAp) scaffold functionalized with Bone Morphogenetic Protein-2 (BMP-2) and strontium-ion-enriched amorphous calcium phosphate (Sr-ACP). The results showed that the addition of BMP-2 improved the morphology and activity of osteoblasts on the scaffold, leading to increased expression of genes related to osteoblast differentiation and matrix synthesis. This suggests that the incorporation of BMP-2 enhances the efficacy of the osteochondral scaffold in challenging conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
M. T. Ciubuc-Batcu, N. J. C. Stapelberg, J. P. Headrick, G. M. C. Renshaw
Summary: The nervous system relies on mitochondria, and impaired mitochondrial function is associated with major depressive disorder. Modulating mitochondrial function may be a therapeutic target for treating MDD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Correction
Biochemistry & Molecular Biology
Saowaluk Saisomboon, Ryusho Kariya, Piyanard Boonnate, Kanlayanee Sawanyawisuth, Ubon Cha'on, Vor Luvira, Yaovalux Chamgramol, Chawalit Pairojkul, Wunchana Seubwai, Atit Silsirivanit, Sopit Wongkham, Seiji Okada, Sarawut Jitrapakdee, Kulthida Vaeteewoottacharn
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Pavan Thapak, Zhe Ying, Victoria Palafox-Sanchez, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla
Summary: Traumatic brain injury (TBI) impairs cellular energy demand, compromising neuronal function and plasticity. This study demonstrates that the mitochondrial activator humanin (HN) can counteract the reduction in mitochondrial bioenergetics caused by TBI, restore memory function and synaptic protein levels, and suppress inflammation and astrocyte proliferation. HN plays an integral role in normalizing fundamental aspects of TBI pathology.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Paul Murphy, Valeria A. Buzinova, Carrie E. Johnson
Summary: Progress has been made in the treatment of Alzheimer's disease through the development of anti-A beta therapeutics, which have shown modest efficacy in slowing the progression of the disease. However, the puzzling issue remains as to why completely removing A beta does not fully stop the disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Mengxin Li, Xuanzhong Wang, Xuyang Chen, Jinghui Hong, Ye Du, Dong Song
Summary: Pancreatic adenocarcinoma (PAAD) is a common digestive malignant tumor with limited treatment options. This study demonstrates that TGM2 may serve as a marker for treatment and prognosis in pancreatic cancer patients. Co-treatment of low dose cisplatin (DDP) and the TGM2 inhibitor GK921 effectively inhibits PAAD cell viability and proliferation in vitro and in vivo, by inhibiting epithelial-to-mesenchymal transition (EMT) induced by TGM2 and enhancing cell cycle arrest and apoptosis caused by DDP. These findings suggest that the combination of GK921 and DDP holds promise as a treatment for PAAD patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Liaoran Niu, Qi Wang, Fan Feng, Wanli Yang, Zhenyu Xie, Gaozan Zheng, Wei Zhou, Lili Duan, Kunli Du, Yiding Li, Ye Tian, Junfeng Chen, Qibin Xie, Aqiang Fan, Hanjun Dan, Jinqiang Liu, Daiming Fan, Liu Hong, Jian Zhang, Jianyong Zheng
Summary: This review provides a comprehensive summary of the interaction between cancer cells and macrophages in the tumor microenvironment, and discusses the role of small extracellular vesicles (sEVs) in this process. It also explores the various effects of macrophage-secreted sEVs on tumor malignant transformation, and addresses the therapeutic advancements and challenges associated with these vesicles.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Neha Sawant, Sudhir Kshirsagar, P. Hemachandra Reddy, Arubala P. Reddy
Summary: Depression is a common neuropsychiatric comorbidity in Alzheimer's disease (AD) and other Tauopathies. Selective serotonin reuptake inhibitor (SSRI) treatment, such as Citalopram, not only has anti-depressive and anxiolytic effects, but also helps improve neurogenesis, reduce amyloid burden & Tau pathologies, and neuroinflammation in AD. In this study, Citalopram was found to reduce pathologically pTau level, increase synaptic gene expression and cytoskeletal structure, as well as improve cell survival, mitochondrial respiration, and mitochondrial morphology in cells expressing mutant APP and Tau. These findings suggest that Citalopram could be a promising therapeutic drug for treating depression and AD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Yueqi Chen, Jiulin Tan, Chuan Yang, Zhiguo Ling, Jianzhong Xu, Dong Sun, Fei Luo
Summary: Bone is a self-healing organ that undergoes continuous regeneration through the cooperation of osteoclasts and osteoblasts. This study used ATAC-seq and RNA-Seq techniques to investigate the chromatin accessibility and transcriptomic landscape of osteoblast differentiation and mineralization. The results showed that global chromatin accessibility was extensively improved during osteoblastogenesis. Additionally, several transcription factors including MEF2A, PRRX1, Shox2, and HOXB13 were found to modulate the promoter accessibility of target genes during osteoblast differentiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Zi-Ran Kang, Shanshan Jiang, Ji-Xuan Han, Yaqi Gao, Yile Xie, Jinxian Chen, Qiang Liu, Jun Yu, Xin Zhao, Jie Hong, Haoyan Chen, Ying-Xuan Chen, Huimin Chen, Jing-Yuan Fang
Summary: The study demonstrates that BCAA metabolism is involved in the development of colorectal cancer (CRC). BCAT2 deficiency promotes CRC progression by inhibiting BCAA metabolism and chronically activating the mTORC1 pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Chao Zheng, Lingling Liu, Caiyun Liu, Fengna Chu, Yue Lang, Shan Liu, Yan Mi, Jie Zhu, Tao Jin
Summary: Inducing tolerogenic dendritic cells (tDCs) with low RelB expression could effectively alleviate symptoms and reduce immune cell infiltration and demyelination in experimental autoimmune encephalomyelitis (EAE) mouse model.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
M. Seco-Cervera, D. Ortiz-Masia, D. C. Macias-Ceja, S. Coll, L. Gisbert-Ferrandiz, J. Cosin-Roger, C. Bauset, M. Ortega, B. Heras-Moran, F. Navarro-Vicente, M. Millan, J. V. Esplugues, S. Calatayud, M. D. Barrachina
Summary: The study revealed the presence of resistance to apoptosis in complicated ileal Crohn's disease, with PDGFB inducing an ETS1-mediated resistance to apoptosis associated with an inflammatory and fibrogenic pattern of expression in intestinal fibroblasts. Potential targets against ileal fibrosis include PDGFRB, IL1R1, or MCL1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Yunmeng Wang, Ping Cheng
Summary: Oncolytic viruses (OVs) are emerging as therapeutically relevant anticancer agents, especially when combined with genetically modified bispecific T cell engagers (BiTEs). This combination strategy can overcome the limitations of BiTEs alone and provide targeted cytotoxicity to solid tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Biochemistry & Molecular Biology
Stephanie Tannous, Hassan Y. Naim
Summary: Congenital sucrase-isomaltase deficiency (CSID) is an autosomal recessive disorder caused by variants in the SI gene. A frameshift mutation called c.273_274delAG (p.Gly92Leufs*8) has been identified in CSID patients in Greenlandic population, which leads to loss of digestive function of SI. Surprisingly, the truncated mutant can still be located on the cell surface and interacts with wild type SI, negatively affecting its enzymatic function. Furthermore, heterozygote carriers of this mutation may also exhibit CSID symptoms.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)