DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of LaminopathiesNovelty and Significance

(2018) Gaelle Auguste et al.   CIRCULATION RESEARCH

p53 regulates the cardiac transcriptome

(2017) Tak W. Mak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In VitroNovelty and Significance

(2016) Priyatansh Gurha et al.   CIRCULATION RESEARCH

Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin GeneNovelty and Significance

(2016) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Molecular insights into the premature aging disease progeria

(2016) Sandra Vidak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Tumor-Suppressor Functions of the TP53 Pathway

(2016) Brandon J. Aubrey et al.   Cold Spring Harbor Perspectives in Medicine

Dynamics of Cell Generation and Turnover in the Human Heart

(2015) Olaf Bergmann et al.   CELL

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Increased Transforming Growth Factor-β Levels Associated With Cardiac Adverse Events in Hypertrophic Cardiomyopathy

(2015) Burak Ayça et al.   CLINICAL CARDIOLOGY

p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload

(2015) Yohko Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

First Japanese case of atypical progeroid syndrome/atypical Werner syndrome with heterozygousLMNAmutation

(2014) Sei-ichiro Motegi et al.   JOURNAL OF DERMATOLOGY

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

(2013) Suet Nee Chen et al.   CIRCULATION RESEARCH

Implantable cardioverter-defibrillators in lamin A/C mutation carriers with cardiac conduction disorders

(2013) Frédéric Anselme et al.   HEART RHYTHM

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity

(2012) Alessandra Ruggiero et al.   CARDIOVASCULAR RESEARCH

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

p53-Upregulated Modulator of Apoptosis (PUMA)

(2011) S. Elissa Altin et al.   CIRCULATION

Puma Deletion Delays Cardiac Dysfunction in Murine Heart Failure Models Through Attenuation of Apoptosis

(2011) Adel Mandl et al.   CIRCULATION

Nuclear Plakoglobin Is Essential for Differentiation of Cardiac Progenitor Cells to Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

(2011) Raffaella Lombardi et al.   CIRCULATION RESEARCH

Mutations in the Lamin A/C gene mimic arrhythmogenic right ventricular cardiomyopathy

(2011) Giovanni Quarta et al.   EUROPEAN HEART JOURNAL

Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes

(2011) Patima Sdek et al.   JOURNAL OF CELL BIOLOGY

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover

(2010) Olaf Bergmann et al.   EXPERIMENTAL CELL RESEARCH

Analysis of p53 and NF-κB signaling in modulating the cardiomyocyte fate during hypertrophy

(2010) Arunachal Chatterjee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β

(2010) Polakit Teekakirikul et al.   JOURNAL OF CLINICAL INVESTIGATION

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Elevated p53 expression is associated with dysregulation of the ubiquitin-proteasome system in dilated cardiomyopathy

(2008) E. J. Birks et al.   CARDIOVASCULAR RESEARCH

Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

(2008) H. Sagelius et al.   JOURNAL OF CELL SCIENCE