Synthesis of rocaglamide derivatives and evaluation of their Wnt signal inhibitory activities

Natural compounds with Wnt signal modulating activity

(2015) Rolly G. Fuentes et al.   NATURAL PRODUCT REPORTS

Limonoids with Wnt signal inhibitory activity isolated from the fruits of Azadirachta excelsa

(2015) Rolly G. Fuentes et al.   Phytochemistry Letters

Ricinine: A pyridone alkaloid from Ricinus communis that activates the Wnt signaling pathway through casein kinase 1α

(2014) Kensuke Ohishi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Calotropin: A Cardenolide fromCalotropis giganteathat Inhibits Wnt Signaling by Increasing Casein Kinase 1α in Colon Cancer Cells

(2014) Hyun Young Park et al.   CHEMBIOCHEM

Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

(2014) Neil J. Lajkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Remodeling of Fumagillol: Discovery of an Oxygen-Directed Oxidative Mannich Reaction

(2014) Alexander J. Grenning et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Mixed 3,3′-Bisindoles and Their Evaluation as Wnt Signaling Inhibitors

(2013) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Flavaglines: potent anticancer drugs that target prohibitins and the helicase eIF4A

(2013) Christine Basmadjian et al.   Future Medicinal Chemistry

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Xylogranin B: A Potent Wnt Signal Inhibitory Limonoid from Xylocarpus granatum

(2013) Kazufumi Toume et al.   ORGANIC LETTERS

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline

(2012) Neil J. Lajkiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in the biology and chemistry of the flavaglines

(2011) Nigel Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Remodelling of the natural product fumagillol employing a reaction discovery approach

(2011) Bradley R. Balthaser et al.   Nature Chemistry

Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation

(2010) Stéphane P. Roche et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Constituents of Amoora cucullata with TRAIL resistance-overcoming activity

(2010) Firoj Ahmed et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells

(2008) Lenka Doubravská et al.   APOPTOSIS

New Wnt/β-Catenin Signaling Inhibitors Isolated fromEleutherine palmifolia

(2008) Xiaofan Li et al.   Chemistry-An Asian Journal