标题
Biased signaling by endogenous opioid peptides
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 117, Issue 21, Pages 11820-11828
出版商
Proceedings of the National Academy of Sciences
发表日期
2020-05-12
DOI
10.1073/pnas.2000712117
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A complex structure of arrestin-2 bound to a G protein-coupled receptor
- (2019) Wanchao Yin et al. CELL RESEARCH
- New concepts in opioid analgesia
- (2018) Christoph Stein EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Opioid Receptors
- (2016) Christoph Stein Annual Review of Medicine
- Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor
- (2016) Georgina L. Thompson et al. BIOCHEMICAL PHARMACOLOGY
- Biased agonism: An emerging paradigm in GPCR drug discovery
- (2016) Zoran Rankovic et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators
- (2016) Andrew C. Kruegel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Practical guide for calculating and representing biased signaling by GPCR ligands: A stepwise approach
- (2016) Karim Nagi et al. METHODS
- Structure-based discovery of opioid analgesics with reduced side effects
- (2016) Aashish Manglik et al. NATURE
- Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
- (2016) Tarsis F. Brust et al. Science Signaling
- Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria
- (2016) Tarsis F. Brust et al. Science Signaling
- -Opioid Receptor-Mediated Inhibition of Intercalated Neurons and Effect on Synaptic Transmission to the Central Amygdala
- (2015) P. Blaesse et al. JOURNAL OF NEUROSCIENCE
- Noribogaine is a G-protein biased κ-opioid receptor agonist
- (2015) Emeline L. Maillet et al. NEUROPHARMACOLOGY
- Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
- (2015) Lei Zhou et al. NEUROPHARMACOLOGY
- Bias in chemokine receptor signalling
- (2014) Annelien J.M. Zweemer et al. TRENDS IN IMMUNOLOGY
- Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity
- (2014) Georgina L. Thompson et al. Frontiers in Pharmacology
- Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons
- (2013) Peishen Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors
- (2013) Sudarshan Rajagopal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ligand-directed signalling within the opioid receptor family
- (2012) Amynah A Pradhan et al. BRITISH JOURNAL OF PHARMACOLOGY
- 6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment
- (2012) Marie-Laure Rives et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β-arrestin-Biased Agonism at the Parathyroid Hormone Receptor Uncouples Bone Formation from Bone Resorption
- (2012) Brittany N. Bohinc et al. Endocrine Metabolic & Immune Disorders-Drug Targets
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding
- (2011) I. Gomes et al. MOLECULAR PHARMACOLOGY
- Functional Selectivity at the -Opioid Receptor: Implications for Understanding Opioid Analgesia and Tolerance
- (2011) K. M. Raehal et al. PHARMACOLOGICAL REVIEWS
- -Opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization
- (2010) J. McPherson et al. MOLECULAR PHARMACOLOGY
- MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons
- (2010) S. Gouty et al. NEUROSCIENCE
- Herkinorin Analogues with Differential β-Arrestin-2 Interactions
- (2008) Kevin Tidgewell et al. JOURNAL OF MEDICINAL CHEMISTRY
- -Opioid Receptor Expression in the Ventral Tegmental Area Protects Against Elevated Alcohol Consumption
- (2008) E. B. Margolis et al. JOURNAL OF NEUROSCIENCE
- Arrestin Binds to Different Phosphorylated Regions of the Thyrotropin-Releasing Hormone Receptor with Distinct Functional Consequences
- (2008) B. W. Jones et al. MOLECULAR PHARMACOLOGY
- Amygdala intercalated neurons are required for expression of fear extinction
- (2008) Ekaterina Likhtik et al. NATURE
- Physiological and pharmacological implications of beta-arrestin regulation
- (2008) Cullen L. Schmid et al. PHARMACOLOGY & THERAPEUTICS
- β-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction
- (2007) K DeFea BRITISH JOURNAL OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started