A myosin-7B–dependent endocytosis pathway mediates cellular entry of α-synuclein fibrils and polycation-bearing cargos

Type I myosins anchor actin assembly to the plasma membrane during clathrin-mediated endocytosis

(2019) Ross T.A. Pedersen et al.   JOURNAL OF CELL BIOLOGY

Transmission of α-synuclein seeds in neurodegenerative disease: recent developments

(2019) Richard J. Karpowicz et al.   LABORATORY INVESTIGATION

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Actomyosin-driven force patterning controls endocytosis at the immune synapse

(2019) Anita Kumari et al.   Nature Communications

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

(2019) Melissa Birol et al.   PLOS BIOLOGY

Type-I myosins promote actin polymerization to drive membrane bending in endocytosis

(2019) Hetty E Manenschijn et al.   eLife

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of protein homeostasis by unconventional protein secretion in mammalian cells

(2018) Yihong Ye   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cryo-EM structure of alpha-synuclein fibrils

(2018) Ricardo Guerrero-Ferreira et al.   eLife

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

(2018) Giuseppe Condomitti et al.   Frontiers in Molecular Neuroscience

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

(2018) Binsen Li et al.   Nature Communications

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

The Roles of Endo-Lysosomes in Unconventional Protein Secretion

(2018) Juhyung Lee et al.   Cells

Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar Adhesion Complex

(2016) Meredith L. Weck et al.   CURRENT BIOLOGY

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells

(2016) Jin-Gu Lee et al.   NATURE CELL BIOLOGY

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model

(2016) Se Hee Oh et al.   Cell Reports

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

(2013) David J. Irwin et al.   NATURE REVIEWS NEUROSCIENCE

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Myosin 1E coordinates actin assembly and cargo trafficking during clathrin-mediated endocytosis

(2012) Jackie Cheng et al.   MOLECULAR BIOLOGY OF THE CELL

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Differential Requirements for Clathrin-dependent Endocytosis at Sites of Cell–Substrate Adhesion

(2010) Erika M. Batchelder et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Dynamin Mediated Endocytosis by theDynoles—Synthesis and Functional Activity of a Family of Indoles

(2009) Timothy A. Hill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prion-like mechanisms in neurodegenerative diseases

(2009) Bess Frost et al.   NATURE REVIEWS NEUROSCIENCE

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

(2009) B. R. McNaughton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heparin/Heparan Sulfate Biosynthesis

(2008) Pernilla Carlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE