Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice

(2014) Charlotte B. Jendresen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

(2014) Chia-Chen Liu et al.   NEURON

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Amyloid is transmitted via neuronal connections along axonal membranes

(2013) Ha-Lim Song et al.   ANNALS OF NEUROLOGY

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products

(2013) Fang Cheng et al.   GLYCOBIOLOGY

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

(2013) A. P. Sagare et al.   Cold Spring Harbor Perspectives in Medicine

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

A Mass Spectrometric Approach for Characterization of Amyloid-β Aggregates and Identification of Their Post-Translational Modifications

(2012) William M. Tay et al.   BIOCHEMISTRY

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms

(2012) Jie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology

(2012) Pritam Das et al.   Molecular Neurodegeneration

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

(2012) Katherine L Youmans et al.   Molecular Neurodegeneration

Autism-like socio-communicative deficits and stereotypies in mice lacking heparan sulfate

(2012) F. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice

(2011) Steven M. Rauch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

(2011) Katherine Lynn Youmans et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuronal activity regulates the regional vulnerability to amyloid-β deposition

(2011) Adam W Bero et al.   NATURE NEUROSCIENCE

Serotonin signaling is associated with lower amyloid-  levels and plaques in transgenic mice and humans

(2011) J. R. Cirrito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Heparan sulfate mediates amyloid-beta internalization and cytotoxicity

(2010) Elina Sandwall et al.   GLYCOBIOLOGY

IFN-  Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid   Precursor Protein Transgenic Mice

(2010) P. Chakrabarty et al.   JOURNAL OF IMMUNOLOGY

Limited expression of heparan sulphate proteoglycans associated with Aβ deposits in the APPswe/PS1dE9 mouse model for Alzheimer's disease

(2010) N. M. Timmer et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

A Specific Enzyme-Linked Immunosorbent Assay for Measuring β-Amyloid Protein Oligomers in Human Plasma and Brain Tissue of Patients With Alzheimer Disease

(2009) Weiming Xia et al.   ARCHIVES OF NEUROLOGY

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

(2009) Karrie E Grear et al.   Molecular Neurodegeneration

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

(2009) X. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY