Article
Biochemistry & Molecular Biology
Yanlin Ma, Qiaoqiao Chen, Jiahan He, Jing Cao, Zhibin Liu, Jianmei Wang, Yi Yang
Summary: CIPK14 acts as a negative regulator in plant immune response, with loss-of-function mutants displaying enhanced resistance and overexpression plants being more susceptible to bacterial pathogens. Additionally, CIPK14 regulates the expression of PTI marker genes and the phosphorylation status of MPK3/6.
Article
Cell Biology
Julian R. Smith, Jack W. Dowling, Matthew I. McFadden, Andrew Karp, Johannes Schwerk, Joshua J. Woodward, Ram Savan, Adriana Forero
Summary: Cellular stress can activate signaling cascades to elicit inflammatory responses. This study investigates the role of the transcription factor MEF2A in regulating transcriptional stress responses and preventing R-loop accumulation. Loss of MEF2A leads to activation of the ATR kinase, which positively regulates R-loop-associated inflammatory responses.
Article
Plant Sciences
Zhiyuan Lv, Lijuan Hao, Bi Ma, Ziwen He, Yiwei Luo, Youchao Xin, Ningjia He
Summary: Ciboria carunculoides is the main causal agent of mulberry sclerotial disease, and transcriptome sequencing results showed significant changes in gene transcription of secondary metabolism and defense-related hormone pathways in infected mulberry fruit, with activation of salicylic acid signaling and inhibition of jasmonic acid signaling. The small secreted protein CcSSP1 of C. carunculoides activates salicylic acid signaling by targeting pathogenesis-related protein 1 (PR1), revealing the infection strategy of C. carunculoides functions by regulating salicylic acid signaling to inhibit host defense responses.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agronomy
Bodi Li, Ping Tao, Feng Xu, Pingan He, Jinxiang Wang
Summary: Six MIR159 genes were identified in soybean, and their expression patterns varied under different treatments. Additionally, MIR159e may regulate phosphorus absorption and transport in soybean plants.
Article
Immunology
Zhenling Ma, Wenwen Zhang, Wenhui Fan, Yaru Wu, Menghao Zhang, Jun Xu, Wenqing Li, Lei Sun, Wenjun Liu, Wei Liu
Summary: This study revealed the critical role of FoxO1 as a negative regulator in RIG-I-triggered signaling, influencing type I interferon production by controlling multiple pathways, thereby affecting the antiviral immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Fisheries
Yuelian Zou, Xin Xu, Qilin Hu, Yilei Wang, Huiping Yang, Ziping Zhang
Summary: This study identified and analyzed the FREP genes in abalones, revealing their important role in the immune system and significance for disease prevention and control in aquaculture species.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Gabriel K. Griffin, Jingyi Wu, Arvin Iracheta-Vellve, James C. Patti, Jeffrey Hsu, Thomas Davis, Deborah Dele-Oni, Peter P. Du, Aya G. Halawi, Jeffrey J. Ishizuka, Sarah Y. Kim, Susan Klaeger, Nelson H. Knudsen, Brian C. Miller, Tung H. Nguyen, Kira E. Olander, Malvina Papanastasiou, Suzanna Rachimi, Emily J. Robitschek, Emily M. Schneider, Mitchell D. Yeary, Margaret D. Zimmer, Jacob D. Jaffe, Steven A. Carr, John G. Doench, W. Nicholas Haining, Kathleen B. Yates, Robert T. Manguso, Bradley E. Bernstein
Summary: A CRISPR-Cas9 screen in mouse tumour models treated with immune checkpoint blockade identified SETDB1 as an epigenetic checkpoint protein that suppresses tumour-intrinsic immunogenicity. Loss of SETDB1 leads to derepression of immune-stimulating genes and triggers TE-specific cytotoxic T cell responses, suggesting it as a potential target for immunotherapy in cancer treatment.
Article
Food Science & Technology
Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li
Summary: ZEA suppresses macrophage-mediated innate immunity activated by LPS, attenuating the production of proinflammatory mediators and cytokines, inhibiting inflammatory signaling pathways, and repressing inflammasome activation. This suggests that ZEA-contaminated food intake may decrease innate immunity and increase adverse effects during infection.
Article
Plant Sciences
Sejal Asija, Tanashvi Seth, Shahid Umar, Ravi Gupta
Summary: Crop production is affected by pathogens, but plants have evolved innate immunity to recognize pathogens and activate defense responses. In addition to well-established hormones like salicylic acid, jasmonic acid, and ethylene, polyamines (PAs) also play a key role in regulating plant immune responses. PAs synthesized during initial pathogen invasion contribute to resistance and are later catabolized to produce other signaling molecules for hypersensitive response.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Article
Entomology
Ashley L. Waring, Joshua Hill, Brooke M. Allen, Nicholas M. Bretz, Nguyen Le, Pooja Kr, Dakota Fuss, Nathan T. Mortimer
Summary: Summary: This study characterizes the gene expression changes in Drosophila fruit flies following infection by different pathogens and identifies a small number of genes that consistently show expression changes. These findings provide new insight into the transcriptional changes that accompany the immune response in fruit flies and may serve as candidate genes for further study.
Article
Plant Sciences
Nico Tintor, Gea A. M. Nieuweboer, Ilse A. W. Bakker, Frank L. W. Takken
Summary: Plant pathogens use secreted proteins, including effectors, to manipulate their hosts, with some effectors being translocated into host cells to suppress defense signaling. The root-infecting fungus, Fusarium oxysporum, secretes numerous effectors, including Foa3, which can suppress host defenses. Foa3 can enter plant cells and suppress defense responses even without the PR1 secretory signal peptide. Foa3 and other cell penetrating peptides may localize to unknown subcellular structures to enter host cells.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Pan Shen, Xueyi Li, Shimin Fu, Changyong Zhou, Xuefeng Wang
Summary: This study found that a peptide called SECP8 secreted by the citrus huanglongbing bacterium CLas has the ability to suppress immune responses and promote disease development. It also affects the expression of immune-related genes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Chenwei Zhang, Xianyou Wang, Hanwei Li, Jinying Wang, Qi Zeng, Wenting Huang, Haoqiang Huang, Yinshuai Xie, Shangzhen Yu, Qing Kan, Qi Wang, Yuqin Cheng
Summary: This study reveals the molecular mechanism of Grapevine leafroll-associated virus 2 infection. The viral RNA-silencing suppressor 24-kDa protein (p24) interacts with the grapevine transcription factor VvRAV1, altering its function to enhance viral accumulation and weaken host basal defense responses.
Article
Fisheries
Sib Sankar Giri, Sang Guen Kim, Kang Jeong Woo, Won Joon Jung, Sung Bin Lee, Young Min Lee, Su Jin Jo, Mae Hyun Hwang, JaeHong Park, Ji Hyung Kim, V Sukumaran, Se Chang Park
Summary: This study investigated the effects of Bougainvillea glabra leaf as a feed supplement on the growth, immune response, and disease resistance of carp. The results showed that a dietary supplementation with 40g/kg BG leaf significantly improved the growth performance, immune response, and disease resistance of carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Valerio Secli, Claudia Di Biagio, Arianna Martini, Emma Michetti, Francesca Pacello, Serena Ammendola, Andrea Battistoni
Summary: The innate immune responses of zebrafish embryos to microbial infections include strategies based on manipulating the concentration of metals such as iron and zinc. Infection experiments with different Pseudomonas aeruginosa strains have shown that strains lacking critical components of zinc importers have reduced colonization capacity but have an advantage in the early stages of infection. The expression of genes involved in zinc transport suggests the existence of antimicrobial mechanisms based on zinc sequestration, indicating the similarity of nutritional immunity mechanisms between teleosts and higher vertebrates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Michael J. Skelly, Lucas Frungillo, Steven H. Spoel
CURRENT OPINION IN PLANT BIOLOGY
(2016)
Article
Plant Sciences
Byung-Wook Yun, Michael J. Skelly, Minghui Yin, Manda Yu, Bong-Gyu Mun, Sang-Uk Lee, Adil Hussain, Steven H. Spoel, Gary J. Loake
Review
Biochemistry & Molecular Biology
Michael J. Skelly, Gary J. Loake
ANTIOXIDANTS & REDOX SIGNALING
(2013)
Article
Multidisciplinary Sciences
Lucas Frungillo, Michael J. Skelly, Gary J. Loake, Steven H. Spoel, Ione Salgado
NATURE COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Michael J. Skelly, Saad I. Malik, Thierry Le Bihan, Yuan Bo, Jihong Jiang, Steven H. Spoel, Gary J. Loake
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biology
Michael J. Skelly, James J. Furniss, Heather Grey, Ka-Wing Wong, Steven H. Spoel
Editorial Material
Plant Sciences
Michael J. Skelly
Editorial Material
Plant Sciences
Michael J. Skelly
Editorial Material
Plant Sciences
Michael J. Skelly
Article
Cell Biology
Mika Nomoto, Michael J. Skelly, Tomotaka Itaya, Tsuyoshi Mori, Takamasa Suzuki, Tomonao Matsushita, Mutsutomo Tokizawa, Keiko Kuwata, Hitoshi Mori, Yoshiharu Y. Yamamoto, Tetsuya Higashiyama, Hironaka Tsukagoshi, Steven H. Spoel, Yasuomi Tada
Summary: Plants have evolved mechanisms to tailor immune responses against pathogens with different lifestyles by regulating the antagonistic relationship between immune hormones salicylic acid (SA) and jasmonic acid (JA). NPR1 plays a crucial role in activating SA-responsive genes and as a corepressor of JA-responsive MYC2, suppressing pathogen virulence. This study sheds light on the intricate coordination of immune transcriptome by NPR1 in plants.
Article
Multidisciplinary Sciences
Mamoru Matsumura, Mika Nomoto, Tomotaka Itaya, Yuri Aratani, Mizuki Iwamoto, Takakazu Matsuura, Yuki Hayashi, Tsuyoshi Mori, Michael J. Skelly, Yoshiharu Y. Yamamoto, Toshinori Kinoshita, Izumi C. Mori, Takamasa Suzuki, Shigeyuki Betsuyaku, Steven H. Spoel, Masatsugu Toyota, Yasuomi Tada
Summary: Perceiving pathogen signals and environmental cues is crucial for plant immunity. This study reveals that trichomes in plants can sense external mechanical forces, such as raindrops, and induce the expression of defense-related genes through the propagation of intercellular calcium waves, providing early protection against microbial infections.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Michael J. Skelly
Summary: Proper regulation of protein homeostasis is crucial for survival. Ubiquitination is a widespread post-translational modification in eukaryotic cells, while deubiquitinases (DUBs) catalyze the removal of ubiquitin. DUB dysfunction is implicated in many human diseases. The study of plant DUBs has been relatively understudied, but recent findings on new DUB substrates provide insights into their cellular functions.
ESSAYS IN BIOCHEMISTRY
(2022)
Article
Biology
Michael J. Skelly, Steven H. Spoel
Summary: Post-translational modification of proteins by ubiquitin is a crucial cellular signaling mechanism in eukaryotes. Deubiquitinase enzymes play a key role in removing ubiquitin from target proteins, and understanding their function in vitro is an important step in uncovering their cellular roles. The protocols provided in this study for analyzing DUB activity in vitro can be applied to any DUB of interest.
