H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage

(2019) Jinfang Zhang et al.   Cancer Discovery

The response to DNA damage in heterochromatin domains

(2018) Anna Fortuny et al.   CHROMOSOMA

High-throughput screening with nucleosome substrate identifies small-molecule inhibitors of the human histone lysine methyltransferase NSD2

(2018) Nathan P Coussens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of DNA double-strand breaks by mammalian alternative end-joining pathways

(2018) Annahita Sallmyr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

(2018) Thomas Clouaire et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination

(2017) Hai Vu Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Nuclear Receptor–Binding SET Domain Family Histone Lysine Methyltransferases in Cancer

(2017) Richard L. Bennett et al.   Cold Spring Harbor Perspectives in Medicine

Mechanism and regulation of DNA end resection in eukaryotes

(2016) Lorraine S. Symington   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation

(2016) Karine Jacquet et al.   MOLECULAR CELL

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

(2016) M Y Shah et al.   ONCOGENE

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM-mediated KDM2A phosphorylation is required for the DNA damage repair

(2015) L-L Cao et al.   ONCOGENE

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

DNA double strand break repair pathway choice: a chromatin based decision?

(2015) T Clouaire et al.   Nucleus

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional characterization of the TERRA transcriptome at damaged telomeres

(2014) Antonio Porro et al.   Nature Communications

Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair

(2014) Creighton T. Tuzon et al.   Cell Reports

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

(2014) Sophia X. Pfister et al.   Cell Reports

Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions

(2014) Cristina Bartocci et al.   Cell Reports

Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

(2014) Relja Popovic et al.   PLoS Genetics

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint

(2014) Sílvia Carvalho et al.   eLife

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

(2013) Jiangbo Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair

(2013) K.-Y. Hsiao et al.   Journal of Molecular Cell Biology

TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

(2013) Albert Ribes-Zamora et al.   Cell Reports

The Histone Methyltransferase MMSET Regulates Class Switch Recombination

(2012) H. Pei et al.   JOURNAL OF IMMUNOLOGY

Understanding the language of Lys36 methylation at histone H3

(2012) Eric J. Wagner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks

(2012) Andrea J. Hartlerode et al.   PLoS One

Removal of Shelterin Reveals the Telomere End-Protection Problem

(2012) A. Sfeir et al.   SCIENCE

The Histone Methyltransferase and Putative Oncoprotein MMSET Is Overexpressed in a Large Variety of Human Tumors

(2011) H. R. Hudlebusch et al.   CLINICAL CANCER RESEARCH

NSD2 Links Dimethylation of Histone H3 at Lysine 36 to Oncogenic Programming

(2011) Alex J. Kuo et al.   MOLECULAR CELL

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

(2011) Huadong Pei et al.   NATURE

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

(2011) Marieke H. Peuscher et al.   NATURE CELL BIOLOGY

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

(2011) Ildiko Hajdu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

(2010) E. Martinez-Garcia et al.   BLOOD

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

(2010) S. Fnu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMSET is overexpressed in cancers: Link with tumor aggressiveness

(2009) Alboukadel Kassambara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate

(2009) Yan Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Cycle-Dependent Role of MRN at Dysfunctional Telomeres: ATM Signaling-Dependent Induction of Nonhomologous End Joining (NHEJ) in G1 and Resection-Mediated Inhibition of NHEJ in G2

(2009) N. Dimitrova et al.   MOLECULAR AND CELLULAR BIOLOGY

A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf–Hirschhorn syndrome

(2009) Keisuke Nimura et al.   NATURE

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2

(2008) A. Konishi et al.   GENES & DEVELOPMENT

Multiple Myeloma-Related WHSC1/MMSET Isoform RE-IIBP Is a Histone Methyltransferase with Transcriptional Repression Activity

(2008) J.-Y. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor

(2007) J. Marango et al.   BLOOD

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity

(2007) J. Lauring et al.   BLOOD