Activation of the Melanocortin-4 Receptor Prevents Oxidative Damage and Mitochondrial Dysfunction in Cultured Hippocampal Neurons Exposed to Ethanol

Adolescence binge alcohol consumption induces hippocampal mitochondrial impairment that persists during the adulthood

(2019) Cheril Tapia-Rojas et al.   NEUROSCIENCE

NDP-MSH reduces oxidative damage induced by palmitic acid in primary astrocytes

(2019) Delia Ramírez et al.   JOURNAL OF NEUROENDOCRINOLOGY

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling

(2019) Muhammad Ikram et al.   Nutrients

Acute dose of melatonin via Nrf2 dependently prevents acute ethanol-induced neurotoxicity in the developing rodent brain

(2018) Tahir Ali et al.   Journal of Neuroinflammation

Activation of cyclic GMP-dependent protein kinase blocks alcohol-mediated cell death and calcium disruption in cerebellar granule neurons

(2018) Dimitrios E. Kouzoukas et al.   NEUROSCIENCE LETTERS

Chronic ethanol exposure induces SK-N-SH cell apoptosis by increasing N-methyl-D-aspartic acid receptor expression and intracellular calcium

(2018) Hongbo Wang et al.   Experimental and Therapeutic Medicine

Contribution of Tau Pathology to Mitochondrial Impairment in Neurodegeneration

(2018) María J. Pérez et al.   Frontiers in Neuroscience

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

(2018) María José Pérez et al.   Redox Biology

Quercetin and its metabolites protect hepatocytes against ethanol-induced oxidative stress by activation of Nrf2 and AP-1

(2017) Yoo-Jung Lee et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Free radical production and antioxidant status in brain cortex non-synaptic mitochondria and synaptosomes at alcohol hangover onset

(2017) Analía G. Karadayian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adolescent Binge Alcohol Exposure Affects the Brain Function Through Mitochondrial Impairment

(2017) Cheril Tapia-Rojas et al.   MOLECULAR NEUROBIOLOGY

Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease

(2017) María José Pérez et al.   MOLECULAR NEUROBIOLOGY

Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits

(2017) Karina P. Abrahao et al.   NEURON

Synaptic targets: Chronic alcohol actions

(2017) Marisa Roberto et al.   NEUROPHARMACOLOGY

New Implications for the Melanocortin System in Alcohol Drinking Behavior in Adolescents: The Glial Dysfunction Hypothesis

(2017) Juan A. Orellana et al.   Frontiers in Cellular Neuroscience

Alcohol consumption during adolescence: A link between mitochondrial damage and ethanol brain intoxication

(2017) Cheril Tapia-Rojas et al.   Birth Defects Research

The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances

(2016) Jennifer W. Hill et al.   NEUROENDOCRINOLOGY

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

(2015) Stjepana Kovac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption

(2015) Laura M. Saba et al.   FEBS Journal

The emerging role of Nrf2 in mitochondrial function

(2015) Albena T. Dinkova-Kostova et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased Alzheimer's disease–like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy

(2015) Gururaj Joshi et al.   NEUROBIOLOGY OF AGING

A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers

(2015) Patrick D Worhunsky et al.   NEUROPSYCHOPHARMACOLOGY

Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence?

(2015) Linda Patia Spear   PHYSIOLOGY & BEHAVIOR

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

(2013) Rodrigo A Quintanilla et al.   Molecular Neurodegeneration

Thiazolidinediones Promote Axonal Growth through the Activation of the JNK Pathway

(2013) Rodrigo A. Quintanilla et al.   PLoS One

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

(2013) K. M. Holmstrom et al.   Biology Open

Microglia Play a Role in Ethanol-Induced Oxidative Stress and Apoptosis in Developing Hypothalamic Neurons

(2012) Nadka I. Boyadjieva et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Control of food intake by MC4-R signaling in the lateral hypothalamus, nucleus accumbens shell and ventral tegmental area: Interactions with ethanol

(2012) Jose M. Lerma-Cabrera et al.   BEHAVIOURAL BRAIN RESEARCH

MC4-R signaling within the nucleus accumbens shell, but not the lateral hypothalamus, modulates ethanol palatability in rats

(2012) Jose M. Lerma-Cabrera et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons

(2012) Ikram Ullah et al.   BMC NEUROSCIENCE

Mitochondrial Permeability Transition Pore Inhibitors Prevent Ethanol-Induced Neuronal Death in Mice

(2012) Frederic Lamarche et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Melanocortins as potential therapeutic agents in severe hypoxic conditions

(2012) Daniela Giuliani et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Intracellular calcium plays a critical role in the alcohol-mediated death of cerebellar granule neurons

(2012) Dimitrios E. Kouzoukas et al.   JOURNAL OF NEUROCHEMISTRY

NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration

(2012) Liya Qin et al.   Journal of Neuroinflammation

Mitochondrial diseases

(2012) Anthony HV Schapira   LANCET

Assessment of Voluntary Ethanol Consumption and the Effects of a Melanocortin (MC) Receptor Agonist on Ethanol Intake in Mutant C57BL/6J Mice Lacking the MC-4 Receptor

(2011) Montserrat Navarro et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Protective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*

(2011) Alessandra Bitto et al.   CRITICAL CARE MEDICINE

Melanocortin MC4 receptor agonists counteract late inflammatory and apoptotic responses and improve neuronal functionality after cerebral ischemia

(2011) Luca Spaccapelo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Overexpression of Nrf2 Protects Cerebral Cortical Neurons from Ethanol-Induced Apoptotic Death

(2011) M. Narasimhan et al.   MOLECULAR PHARMACOLOGY

Resveratrol Restores Nrf2 Level and Prevents Ethanol-Induced Toxic Effects in the Cerebellum of a Rodent Model of Fetal Alcohol Spectrum Disorders

(2011) A. Kumar et al.   MOLECULAR PHARMACOLOGY

Ethanol-induced HO-1 and NQO1 Are Differentially Regulated by HIF-1α and Nrf2 to Attenuate Inflammatory Cytokine Expression

(2010) Samantha M. Yeligar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Mechanism of alcohol-induced oxidative stress and neuronal injury

(2008) James Haorah et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke

(2008) Alessandra Ottani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM