Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro

(2019) Young J. Yauger et al.   Journal of Neuroinflammation

The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury

(2019) Stephanie W. Lee et al.   Journal of Neuroinflammation

Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis

(2019) Xi-e Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell death–mediated cytokine release and its therapeutic implications

(2019) David E. Place et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Advanced oxidation protein products induce pre-osteoblast apoptosis through a nicotinamide adenine dinucleotide phosphate oxidase-dependent, mitogen-activated protein kinases-mediated intrinsic apoptosis pathway

(2018) Si-Yuan Zhu et al.   AGING CELL

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

(2018) Shalini Swaroop et al.   Journal of Neuroinflammation

Longitudinal electrophysiological changes after cervical hemi-contusion spinal cord injury in rats

(2018) Zucheng Huang et al.   NEUROSCIENCE LETTERS

Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia

(2017) Sabena M. Conley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice

(2017) Wu Jiang et al.   Journal of Neuroinflammation

Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets

(2017) Ramona E. von Leden et al.   JOURNAL OF NEUROTRAUMA

SCI Facts and Figures

(2017)   JOURNAL OF SPINAL CORD MEDICINE

FK506 Attenuates the Inflammation in Rat Spinal Cord Injury by Inhibiting the Activation of NF-κB in Microglia Cells

(2016) Gang Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Downregulation of miR-199b promotes the acute spinal cord injury through IKKβ-NF-κB signaling pathway activating microglial cells

(2016) Heng-Jun Zhou et al.   EXPERIMENTAL CELL RESEARCH

Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury

(2016) Alok Kumar et al.   JOURNAL OF NEUROTRAUMA

Mechanical Design and Analysis of a Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates

(2016) Carolyn J. Sparrey et al.   JOURNAL OF NEUROTRAUMA

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advanced oxidation protein products sensitized the transient receptor potential vanilloid 1 via NADPH oxidase 1 and 4 to cause mechanical hyperalgesia

(2016) Ruoting Ding et al.   Redox Biology

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Methionine Sulfoxide Reductase A Negatively Controls Microglia-Mediated Neuroinflammation via Inhibiting ROS/MAPKs/NF-κB Signaling Pathways Through a Catalytic Antioxidant Function

(2015) Hua Fan et al.   ANTIOXIDANTS & REDOX SIGNALING

Advanced oxidation protein products induce chondrocyte apoptosis via receptor for advanced glycation end products-mediated, redox-dependent intrinsic apoptosis pathway

(2015) Qian Wu et al.   APOPTOSIS

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Plasmatic oxidative stress biomarkers in multiple sclerosis: Relation with clinical and demographic characteristics

(2015) Livia Pasquali et al.   CLINICAL BIOCHEMISTRY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury

(2014) S. J. Cooney et al.   FREE RADICAL RESEARCH

A Key Role for Redox Signaling in Rapid P2X7 Receptor-Induced IL-1  Processing in Human Monocytes

(2014) J. Hewinson et al.   JOURNAL OF IMMUNOLOGY

Paroxetine ameliorates lipopolysaccharide-induced microglia activation via differential regulation of MAPK signaling

(2014) Rong-Pei Liu et al.   Journal of Neuroinflammation

1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells

(2014) Li Tao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Advanced oxidation protein products induce intestine epithelial cell death through a redox-dependent, c-jun N-terminal kinase and poly (ADP-ribose) polymerase-1-mediated pathway

(2014) F Xie et al.   Cell Death & Disease

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments

(2013) Moritz Haneklaus et al.   CURRENT OPINION IN IMMUNOLOGY

The patients with clinically isolated syndrome and relapsing remitting multiple sclerosis show different levels of advanced protein oxidation products and total thiol content in plasma and CSF

(2013) Srdjan Ljubisavljevic et al.   NEUROCHEMISTRY INTERNATIONAL

Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection

(2012) Hsien-Chih Chen et al.   JOURNAL OF SURGICAL RESEARCH

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Spinal cord injury therapies in humans: an overview of current clinical trials and their potential effects on intrinsic CNS macrophages

(2011) John C Gensel et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Role of microglia in CNS inflammation

(2011) Manuel B. Graeber et al.   FEBS LETTERS

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Oxidative stress in spinal cord injury and antioxidant-based intervention

(2011) Z Jia et al.   SPINAL CORD

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

Aspiration of a cervical spinal contusion injury in preparation for delayed peripheral nerve grafting does not impair forelimb behavior or axon regeneration

(2008) Harra R. Sandrow et al.   EXPERIMENTAL NEUROLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE