Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice

NLRP3 inflammasome mediates interleukin-1βproduction in immune cells in response toAcinetobacter baumanniiand contributes to pulmonary inflammation in mice

(2017) Min-Jung Kang et al.   IMMUNOLOGY

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

(2017) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype

(2017) Jie Wu et al.   Journal of Neuroinflammation

An Agonist of the Protective Factor SIRT1 Improves Functional Recovery and Promotes Neuronal Survival by Attenuating Inflammation after Spinal Cord Injury

(2017) Haihong Chen et al.   JOURNAL OF NEUROSCIENCE

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

(2017) Shuang Jiang et al.   PHARMACOLOGICAL RESEARCH

Graft of the NT-3 persistent delivery gelatin sponge scaffold promotes axon regeneration, attenuates inflammation, and induces cell migration in rat and canine with spinal cord injury

(2016) Ge Li et al.   BIOMATERIALS

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

(2016) Amanda Ellis et al.   BRAIN BEHAVIOR AND IMMUNITY

Naringenin inhibits spinal cord injury-induced activation of neutrophils through miR-223

(2016) Long-Bao Shi et al.   GENE

Lipin-2 regulates NLRP3 inflammasome by affecting P2X 7 receptor activation

(2016) Gema Lordén et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injury

(2016) Chuan-Wen Chiu et al.   Journal of Neuroinflammation

Neuroprotective effect of asiatic acid against spinal cord injury in rats

(2016) Wu Jiang et al.   LIFE SCIENCES

Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation

(2016) Di Zhang et al.   MOLECULAR NEUROBIOLOGY

Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation

(2016) Peter M. Grace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quercetin suppresses NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury

(2016) W Jiang et al.   SPINAL CORD

Dopamine D1 Receptor Agonist A-68930 Inhibits NLRP3 Inflammasome Activation, Controls Inflammation, and Alleviates Histopathology in a Rat Model of Spinal Cord Injury

(2016) Wu Jiang et al.   SPINE

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

(2015) Shuang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury

(2015) Guzal Khayrullina et al.   Journal of Neuroinflammation

Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor

(2015) Yuanyi Wang et al.   MOLECULAR NEUROBIOLOGY

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

(2015) Adib Zendedel et al.   MOLECULAR NEUROBIOLOGY

Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury

(2015) Y. Wang et al.   NEUROSCIENCE

Honokiol Downregulates Kruppel-Like Factor 4 Expression, Attenuates Inflammation, and Reduces Histopathology After Spinal Cord Injury in Rats

(2015) Jia Liu et al.   SPINE

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Methylprednisolone for Acute Spinal Cord Injury: 5-Year Practice Reversal

(2014) R. John Hurlbert et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

NLRP3 Inflammasome Mediates Albumin-induced Renal Tubular Injury through Impaired Mitochondrial Function

(2014) Yibo Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrophilic Warhead-Based Design of Compounds Preventing NLRP3 Inflammasome-Dependent Pyroptosis

(2014) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies

(2014) Irene Paterniti et al.   Journal of Neuroinflammation

Neutrophil contribution to spinal cord injury and repair

(2014) Virginie Neirinckx et al.   Journal of Neuroinflammation

Mitochondria-Targeted Peptide Reverses Mitochondrial Dysfunction and Cognitive Deficits in Sepsis-Associated Encephalopathy

(2014) Jing Wu et al.   MOLECULAR NEUROBIOLOGY

Beneficial effects of thymosin β4 on spinal cord injury in the rat

(2014) Peng Cheng et al.   NEUROPHARMACOLOGY

Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice

(2013) Alessandra Bitto et al.   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

(2012) Alexander Rodriguez Guerrero et al.   Journal of Neuroinflammation

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Reactive Astrocytes Inhibit the Survival and Differentiation of Oligodendrocyte Precursor Cells by Secreted TNF-α

(2011) Zhida Su et al.   JOURNAL OF NEUROTRAUMA

Prevention of Both Neutrophil and Monocyte Recruitment Promotes Recovery after Spinal Cord Injury

(2011) Sang Mi Lee et al.   JOURNAL OF NEUROTRAUMA

Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury

(2011) Melanie L. McEwen et al.   Neurotherapeutics

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure

(2007) Michael T. Fitch et al.   EXPERIMENTAL NEUROLOGY