TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis

PU.1 controls fibroblast polarization and tissue fibrosis

(2019) Thomas Wohlfahrt et al.   NATURE

Poly(ADP-ribose) polymerase-1 regulates fibroblast activation in systemic sclerosis

(2018) Yun Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Targeting TGF-β signaling for the treatment of fibrosis

(2018) Andrea Hermina Györfi et al.   MATRIX BIOLOGY

Epigenetics in fibrosis

(2017) Steven O’Reilly   MOLECULAR ASPECTS OF MEDICINE

Epigenetic factors as drivers of fibrosis in systemic sclerosis

(2017) Christina Bergmann et al.   Epigenomics

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

(2017) Debomita Chakraborty et al.   Nature Communications

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes

(2017) Brooke Rhead et al.   Arthritis & Rheumatology

Epigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis

(2016) I. C. Evans et al.   CLINICAL SCIENCE

DNA methylation in fibrosis

(2016) Christopher Dowson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Epigenetics in liver disease: from biology to therapeutics

(2016) Timothy Hardy et al.   GUT

Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis

(2016) Li Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways

(2016) Kunxin Luo   Cold Spring Harbor Perspectives in Biology

Genome-wide methylation analysis demonstrates that 5-aza-2-deoxycytidine treatment does not cause random DNA demethylation in fragile X syndrome cells

(2016) Elisabetta Tabolacci et al.   Epigenetics & Chromatin

Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies

(2015) Clara Dees et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis

(2015) Yoshihide Asano   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

(2015) Katrin Palumbo-Zerr et al.   NATURE MEDICINE

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

(2015) Moon-Hong Kim et al.   PLoS One

Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling

(2014) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide DNA methylation analysis in dermal fibroblasts from patients with diffuse and limited systemic sclerosis reveals common and subset-specific DNA methylation aberrancies

(2014) Nezam Altorok et al.   ANNALS OF THE RHEUMATIC DISEASES

Vitamin D receptor regulates TGF-β signalling in systemic sclerosis

(2014) Pawel Zerr et al.   ANNALS OF THE RHEUMATIC DISEASES

The molecular regulation of Janus kinase (JAK) activation

(2014) Jeffrey J. Babon et al.   BIOCHEMICAL JOURNAL

DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis

(2014) Y.Y. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

Epigenetics, the holy grail in the pathogenesis of systemic sclerosis

(2014) Nezam Altorok et al.   RHEUMATOLOGY

Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis

(2014) Shinji Noda et al.   Nature Communications

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

(2013) Frank van den Hoogen et al.   ARTHRITIS AND RHEUMATISM

Epigenetic repression of bone morphogenetic protein receptor II expression in scleroderma

(2013) Yongqing Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

miR-150 Down-Regulation Contributes to the Constitutive Type I Collagen Overexpression in Scleroderma Dermal Fibroblasts via the Induction of Integrin β3

(2012) Noritoshi Honda et al.   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

(2012) Angelika Horn et al.   ANNALS OF THE RHEUMATIC DISEASES

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

(2012) Christian Beyer et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK-2 as a novel mediator of the profibrotic effects of transforming growth factor β in systemic sclerosis

(2012) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-induced decreases in SOCS3 increase STAT3 activation and upregulate VEGF gene expression

(2012) Kiyotaka Yokogami et al.   Brain Tumor Pathology

The biology and mechanism of action of suppressor of cytokine signaling 3

(2012) Jeffrey J. Babon et al.   GROWTH FACTORS

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

The role of promoter hypermethylation in fibroblast activation and fibrogenesis

(2012) Elisabeth M Zeisberg et al.   JOURNAL OF PATHOLOGY

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

The transcription factor JunD mediates transforming growth factor  -induced fibroblast activation and fibrosis in systemic sclerosis

(2011) K. Palumbo et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis

(2011) Clara Dees et al.   ARTHRITIS AND RHEUMATISM

Platelet-derived serotonin links vascular disease and tissue fibrosis

(2011) Clara Dees et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methylation determines fibroblast activation and fibrogenesis in the kidney

(2010) Wibke Bechtel et al.   NATURE MEDICINE

Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior

(2010) Francesco Pierconti et al.   PROSTATE

Treatment with imatinib prevents fibrosis in different preclinical models of systemic sclerosis and induces regression of established fibrosis

(2009) Alfiya Akhmetshina et al.   ARTHRITIS AND RHEUMATISM

Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities

(2009) A. Mottok et al.   BLOOD

SOCS6, down-regulated in gastric cancer, inhibits cell proliferation and colony formation

(2009) Rai-Hua Lai et al.   CANCER LETTERS

New Mechanisms of Pulmonary Fibrosis

(2009) Robert M. Strieter et al.   CHEST

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders

(2008) N. Fourouclas et al.   HAEMATOLOGICA

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY