NovelN-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors

(S)-Allyl Cysteine Derivatives as a New-type Cholinesterase Inhibitor

(2015) Beom-Cheol Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

(2014) Boris Brus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Performance of the MM/GBSA scoring using a binding site hydrogen bond network-based frame selection: the protein kinase case

(2014) Francisco Adasme-Carreño et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

(2013) Florian Nachon et al.   BIOCHEMICAL JOURNAL

Selective activity of 2,4-diaryl-1,2,3,4-tetrahydroquinolines on Trypanosoma cruzi epimastigotes and amastigotes expressing β-galactosidase

(2013) Cristina Fonseca-Berzal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors

(2013) Margarita Gutiérrez et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Efficient one-pot synthesis of novel and diverse tetrahydroquinolines bearing pyranopyrazoles using organocatalyzed domino Knoevenagel/hetero Diels–Alder reactions

(2013) Rameshwar Prasad Pandit et al.   MOLECULAR DIVERSITY

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

(2012) Christopher A. Lipinski et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthesis and antifungal activity of diverse C-2 pyridinyl and pyridinylvinyl substituted quinolines

(2012) Vladimir V. Kouznetsov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Propargylamine-derived multitarget-directed ligands: fighting Alzheimer’s disease with monoamine oxidase inhibitors

(2012) Irene Bolea et al.   JOURNAL OF NEURAL TRANSMISSION

In Vitro Activity Against Trypanosoma cruzi and Leishmania chagasi Parasites of 2,4-Diaryl 1,2,3,4-Tetrahydroquinoline Derivatives

(2012) Arnold R. Romero Bohorquez et al.   Letters in Drug Design & Discovery

A Novel Class of Selective Acetylcholinesterase Inhibitors: Synthesis and Evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles

(2012) Pedro Torre et al.   MOLECULES

Advances in the Chemistry of Tetrahydroquinolines

(2011) Vellaisamy Sridharan et al.   CHEMICAL REVIEWS

Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking

(2011) Fabiana Caporuscio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease

(2011) Kh. Dhanachandra Singh et al.   JOURNAL OF MOLECULAR MODELING

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cholinergic therapy in dementia

(2010) P. J. Whitehouse   ACTA NEUROLOGICA SCANDINAVICA

Targeting Alzheimer’s disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238

(2010) Stefano Rizzo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The economic impact of dementia in Europe in 2008-cost estimates from the Eurocode project

(2010) A. Wimo et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Biological Activities of Quinoline Derivatives

(2010) Suresh Kumar et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

An Efficient and Short Synthesis of 4-Aryl-3-methyltetrahydroquinolines from N-Benzylanilines and Propenylbenzenes through Cationic Imino Diels-Alder Reactions

(2010) Vladimir Kouznetsov et al.   SYNLETT

Process Development and Scale Up of a Glycine Antagonist

(2009) Adam Banks et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Practical One‐Pot Procedure for the Synthesis of 1,2,3,4‐Tetrahydroquinolines by the Imino‐Diels‐Alder Reaction

(2008) Christoph M. Dehnhardt et al.   SYNTHETIC COMMUNICATIONS

Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids

(2008) Vladimir V. Kouznetsov   TETRAHEDRON