Chemical Synthesis of K34-Ubiquitylated H2B for Nucleosome Reconstitution and Single-Particle Cryo-Electron Microscopy Structural Analysis

Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis

(2016) Man Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monomer/Oligomer Quasi-Racemic Protein Crystallography

(2016) Shuai Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

(2016) Somasekhar Bondalapati et al.   Nature Chemistry

Semisynthetic UbH2A reveals different activities of deubiquitinases and inhibitory effects of H2A K119 ubiquitination on H3K36 methylation in mononucleosomes

(2016) Xiaobao Bi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Hybrid phase ligation for efficient synthesis of histone proteins

(2016) Ruixuan R. Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural basis for histone H2B deubiquitination by the SAGA DUB module

(2016) M. T. Morgan et al.   SCIENCE

Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

(2016) Linjiao Zhou et al.   Nature Communications

Aromatic thiol-mediated cleavage of N–O bonds enables chemical ubiquitylation of folded proteins

(2016) Caroline E. Weller et al.   Nature Communications

Structural and biochemical analyses of monoubiquitinated human histones H2B and H4

(2016) Shinichi Machida et al.   Open Biology

Convergent Versus Sequential Protein Synthesis: The Case of Ubiquitinated and Glycosylated H2B

(2015) Mallikanti Seenaiah et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin

(2015) Matthew T. Holt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical synthesis of crystalline proteins

(2015) Yichao Huang et al.   Science China-Chemistry

Chemical synthesis of proteins using hydrazide intermediates

(2015) Yi-Chao Huang et al.   National Science Review

Peptideo-Aminoanilides as Crypto-Thioesters for Protein Chemical Synthesis

(2014) Jia-Xing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Writing and reading H2B monoubiquitylation

(2014) Gilad Fuchs et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Native chemical ubiquitination using a genetically incorporated azidonorleucine

(2014) Renliang Yang et al.   CHEMICAL COMMUNICATIONS

Post-Translational Modifications of Histones That Influence Nucleosome Dynamics

(2014) Gregory D. Bowman et al.   CHEMICAL REVIEWS

Histones: At the Crossroads of Peptide and Protein Chemistry

(2014) Manuel M. Müller et al.   CHEMICAL REVIEWS

A method for evaluating nucleosome stability with a protein-binding fluorescent dye

(2014) Hiroyuki Taguchi et al.   METHODS

H2B Ubiquitylation Promotes RNA Pol II Processivity via PAF1 and pTEFb

(2014) Lipeng Wu et al.   MOLECULAR CELL

One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones

(2014) Jiabin Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of New Thioester Equivalents for Protein Chemical Synthesis

(2013) Ji-Shen Zheng et al.   ACCOUNTS OF CHEMICAL RESEARCH

New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin

(2013) Yi-Tong Li et al.   JOURNAL OF PEPTIDE SCIENCE

ASH2L Regulates Ubiquitylation Signaling to MLL: trans-Regulation of H3 K4 Methylation in Higher Eukaryotes

(2013) Lipeng Wu et al.   MOLECULAR CELL

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

N-Methylation of Isopeptide Bond as a Strategy to Resist Deubiquitinases

(2012) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stability of Nucleosomes Containing Homogenously Ubiquitylated H2A and H2B Prepared Using Semisynthesis

(2012) Beat Fierz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expeditious Chemical Synthesis of Ubiquitinated Peptides Employing Orthogonal Protection and Native Chemical Ligation

(2011) K. S. Ajish Kumar et al.   BIOCONJUGATE CHEMISTRY

The RING Finger Protein MSL2 in the MOF Complex Is an E3 Ubiquitin Ligase for H2B K34 and Is Involved in Crosstalk with H3 K4 and K79 Methylation

(2011) Lipeng Wu et al.   MOLECULAR CELL

The United States of Histone Ubiquitylation and Methylation

(2011) Michael Werner et al.   MOLECULAR CELL

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology

Highly Efficient and Chemoselective Peptide Ubiquitylation

(2009) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual Native Chemical Ligation at Lysine

(2009) Renliang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE