Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin

(2015) Matthew T. Holt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histones: At the Crossroads of Peptide and Protein Chemistry

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Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo

(2014) H. Vlaming et al.   EMBO REPORTS

Chromatin as an expansive canvas for chemical biology

(2012) Beat Fierz et al.   Nature Chemical Biology

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Interaction between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4

(2011) Jay M. Janz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing

(2011) Yoh-Hei Takahashi et al.   MOLECULAR CELL

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology

Structure–Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B

(2009) Robert K. McGinty et al.   ACS Chemical Biology

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

Crosstalk among Histone Modifications

(2008) Tamaki Suganuma et al.   CELL

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE