MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor

The Pentose Phosphate Pathway and Its Involvement in Cisplatin Resistance

(2020) Isabella Giacomini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines

(2020) Carlos Cantonero et al.   Cancers

Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor

(2019) Chia-Chi Liu et al.   BMC CANCER

Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain–Blood Barrier and Glioblastoma Stem Cells

(2019) Iris Chiara Salaroglio et al.   MOLECULAR PHARMACEUTICS

The Molecular Function of σ Receptors: Past, Present, and Future

(2019) Hayden R. Schmidt et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MRP1 modulators synergize with buthionine sulfoximine to exploit collateral sensitivity and selectively kill MRP1-expressing cancer cells

(2019) Christine C. Gana et al.   BIOCHEMICAL PHARMACOLOGY

LncRNA-MALAT1 contributes to the cisplatin-resistance of lung cancer by upregulating MRP1 and MDR1 via STAT3 activation

(2018) Zhixian Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (σ 2 ) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors

(2018) Maria Laura Pati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Sigma-2 receptor: past, present and perspectives on multiple therapeutic exploitations

(2018) Carmen Abate et al.   Future Medicinal Chemistry

Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells

(2018) Kee Wee Tan et al.   DRUG METABOLISM AND DISPOSITION

Design, Biological Evaluation, and Molecular Modeling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-Glycoprotein Ligand Overcoming Multidrug Resistance in Cancer Stem Cells

(2018) Chiara Riganti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design, synthesis and biological evaluation of thiosemicarbazones, hydrazinobenzothiazoles and arylhydrazones as anticancer agents with a potential to overcome multidrug resistance

(2016) Veronika F.S. Pape et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Two repeated low doses of doxorubicin are more effective than a single high dose against tumors overexpressing P-glycoprotein

(2015) Chiara Riganti et al.   CANCER LETTERS

MRP1 and its role in anticancer drug resistance

(2015) Jamie F. Lu et al.   DRUG METABOLISM REVIEWS

Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents

(2015) Maria Laura Pati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: Small structural changes address the mechanism of interaction at the efflux pump

(2015) Carmen Abate et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells

(2015) Joanna Kopecka et al.   Oncotarget

Editorial: Multidrug Resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

(2015) Chiara Riganti et al.   Frontiers in Oncology

Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

(2014) Gergely Szakács et al.   CHEMICAL REVIEWS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Sigma-2 Receptor Agonists as Possible Antitumor Agents in Resistant Tumors: Hints for Collateral Sensitivity

(2013) Mauro Niso et al.   ChemMedChem

Collateral sensitivity as a strategy against cancer multidrug resistance

(2012) Kristen M. Pluchino et al.   DRUG RESISTANCE UPDATES

Targeting MDR in breast and lung cancer: Discriminating its potential importance from the failure of drug resistance reversal studies

(2012) Laleh Amiri-Kordestani et al.   DRUG RESISTANCE UPDATES

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

(2011) Manuela Polimeni et al.   BIOCHEMICAL JOURNAL

Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers

(2011) Carmen Abate et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting maladaptive glutathione responses in lung disease

(2010) Neal S. Gould et al.   BIOCHEMICAL PHARMACOLOGY

Iodination of verapamil for a stronger induction of death, through GSH efflux, of cancer cells overexpressing MRP1

(2010) Régis Barattin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil

(2009) Rémi-Martin Laberge et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

ABC Efflux Pump-Based Resistance to Chemotherapy Drugs

(2009) Paul D. W. Eckford et al.   CHEMICAL REVIEWS

ABC Pumps and Their Role in Active Drug Transport

(2009) Nicola Colabufo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Perspectives of P-Glycoprotein Modulating Agents in Oncology and Neurodegenerative Diseases: Pharmaceutical, Biological, and Diagnostic Potentials

(2009) Nicola Antonio Colabufo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Is resistance useless? Multidrug resistance and collateral sensitivity

(2009) Matthew D. Hall et al.   TRENDS IN PHARMACOLOGICAL SCIENCES